Article
Medicine, General & Internal
Xiaoli Xiang, Zijia Ji, Tingwang Jiang, Zhengru Huang, Jing Yan
Summary: This study investigated the association between serum magnesium levels and diabetic macular edema (DME) in patients with diabetic retinopathy (DR). The results showed that higher serum magnesium levels were associated with a lower risk of DME in patients with DR. Furthermore, DR patients who used insulin were more likely to develop DME. Long-term studies on oral magnesium supplements are needed to determine whether maintaining higher serum magnesium levels can reduce the risk of DME in DR patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Marc Baget-Bernaldiz, Ramon Sagarra, Esther Hervas, Reyes Blasco, Julia Molina, Empar F. Moreno, Eugeni Garcia-Curto
Summary: The study found that during the COVID-19 pandemic, attendance in the diabetes screening program decreased in 2020 and then recovered in 2021. Additionally, there was a slight increase in cases of the most severe forms of diabetic retinopathy starting in 2021.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Review
Biochemistry & Molecular Biology
Cameron D. Haydinger, Genevieve F. Oliver, Liam M. Ashander, Justine R. Smith
Summary: Diabetic retinopathy is a retinal disease associated with hyperglycemia in diabetes patients, affecting both the central and peripheral retina. Its major mechanism involves oxidative stress caused by elevated production of reactive oxygen species, which is particularly harmful to the retina due to its high metabolic activity. This review provides an overview of the role of oxidative stress in diabetic retinopathy, including the formation and effects of advanced glycation end-products, metabolic memory, and non-coding RNA, as well as potential therapeutic strategies.
Review
Nutrition & Dietetics
Janika Shah, Zi Yu Cheong, Bingyao Tan, Damon Wong, Xinyu Liu, Jacqueline Chua
Summary: This systematic review comprehensively summarizes the current understanding of the associations between dietary consumption, diabetic retinopathy (DR), and diabetic macular edema (DME). The review found that higher intakes of fruits, vegetables, dietary fibers, fish, a Mediterranean diet, oleic acid, and tea were protective against DR, while high intakes of diet soda, caloric intake, rice, and choline were associated with a higher risk of DR. There was no association between vitamin C, riboflavin, vitamin D, milk, and DR. A single study assessed dietary intake and DME, and found a risk of high sodium intake for DME progression.
Article
Immunology
Jing Huang, Qiong Zhou
Summary: This study investigates the role of T-helper 17 (Th17) cell-related genes in the progression of diabetic macular edema (DME). It identifies a set of Th17-related genes that can distinguish between different stages of diabetic nephropathy (DN) and diabetic retinopathy (DR). These findings contribute to our understanding of the molecular mechanisms underlying the interaction between Th17 cells in the eye and kidney in diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Sungsoon Hwang, Se Woong Kang, Sang Jin Kim, Kyu Na Lee, Kyungdo Han, Dong Hui Lim
Summary: This nationwide cohort study aimed to investigate the risk factors for exudative age-related macular degeneration (AMD) in individuals with diabetes. The study analyzed authorized clinical data from the Korean National Health Insurance Service, involving over 1.7 million participants. Data on various factors including duration of diabetes, insulin usage, and presence of vision-threatening diabetic retinopathy were collected, and the association with incident exudative AMD was assessed using a multivariable-adjusted Cox proportional hazard model.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Yi-Ting Hsieh, Ming-Chia Hsieh
Summary: The study found that remission of microalbuminuria was an independent protecting factor for preventing the development of PDR and DME. Aggressive treatment for DKD might help prevent the progression of DR.
ACTA OPHTHALMOLOGICA
(2021)
Article
Endocrinology & Metabolism
Dariusz Tarasewicz, Carol Conell, Lisa K. Gilliam, Ronald B. Melles
Summary: The study aimed to determine the importance of blood sugar control, blood pressure, and other systemic factors on the risk of diabetic retinopathy progression. The findings confirmed that glucose control, as measured by HbA1c, was the most important modifiable risk factor, followed by blood pressure control and total cholesterol. Non-white patients generally had a higher risk of progression to diabetic retinopathy, while Asian patients were less likely to develop diabetic macular edema.
ACTA DIABETOLOGICA
(2023)
Article
Ophthalmology
Jennifer B. Nadelmann, Charles G. Miller, Brendan Mcgeehan, Yinxi Yu, Brian L. Vanderbeek
Summary: A retrospective cohort study found no association between exposure to SGLT2 inhibitor therapy and progression of non-proliferative diabetic retinopathy in comparison to standard care.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Yingrui Yang, Hongmei Zhang, Mengting Xia, Ranran Huang, Yuming Wang, Zhijie Li
Summary: The study found that different age, region, disease duration, and DR severity could affect the prevalence and association rules of eye diseases in diabetic patients. Patients in rural areas and older age groups are more likely to develop eye diseases, and those with multiple eye diseases concurrently have a higher risk.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Chewang U. Bhutia, Prempal Kaur, Karamjit Singh, Sukhraj Kaur
Summary: This study investigated the correlation between serum inflammatory and metabolic biomarkers in patients with diabetic retinopathy (DR) and diabetic macular edema (DME). The results showed significant differences in the levels of IL-6 and CRP between patients with and without DR, with a positive correlation between IL-6 and CRP and the severity of DR. Only IL-6 was found to be significantly elevated in DR patients with DME compared to those without DME. None of the metabolic markers correlated significantly with DR and DME.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chaoyang Zhang, Dawei Luo, Hai Xie, Qian Yang, Dandan Liu, Lei Tang, Jingting Zhang, Weiye Li, Haibin Tian, Lixia Lu, Xiaodong Sun, Guo-Tong Xu, Jingfa Zhang
Summary: Retinal Muller glial dysfunction and intracellular edema in diabetic retinopathy (DR) are associated with down-regulation of Aquaporin 11 (AQP11). AQP11 overexpression alleviates intracellular edema, enhances glutamate metabolism, and reduces cell death. The down-regulation of AQP11 in DR is mediated by the miRNA-AQP11 axis, which is partially reversed by AQP11 overexpression. Targeting AQP11 regulation may provide a new therapeutic strategy for diabetic macular edema (DME).
PHARMACOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Tsung-Cheng Hsieh, Guang-Hong Deng, Yung-Ching Chang, Fang-Ling Chang, Ming-Shan He
Summary: This study aimed to investigate optical coherence tomography (OCT) biomarkers of diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) therapy. The results showed that partially continuous inner segment-outer segment (IS-OS) layers were predictive of better response, while epiretinal membrane (ERM) was a significant predictor of poor response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Taraprasad Das, Gudlavalleti V. S. Murthy, Hira B. Pant, Clare Gilbert, Ramachandran Rajalakshmi, Umesh C. Behera
Summary: The study revealed significant zonal variations in the prevalence of DR and related factors in individuals with T2DM in different regions of India. The east zone had higher rates of DR, sight-threatening DR, and blindness, the south zone had higher rates of diabetic macular edema, the west zone had higher rates of visual impairment, and the south-central zone had higher rates of systemic hypertension.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
