The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression

MicroRNA-622 is a novel mediator of tumorigenicity in melanoma by targeting Kirsten rat sarcoma

(2018) Peter Dietrich et al.   Pigment Cell & Melanoma Research

CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells

(2018) Siriluck Wattanavanitchakorn et al.   PLoS One

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression

(2018) Bhavna Rani et al.   Cell Death & Disease

Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance

(2017) Peter Dietrich et al.   GUT

Human hepatocellular carcinomas with a periportal phenotype have the lowest potential for early recurrence after curative resection

(2017) Romain Désert et al.   HEPATOLOGY

E2F1 interactive with BRCA1 pathway induces HCC two different small molecule metabolism or cell cycle regulation via mitochondrion or CD4+T to cytosol

(2017) Qingchun Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

(2017) Lindsey N. Kent et al.   JOURNAL OF CLINICAL INVESTIGATION

PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization

(2017) Serena Muratcioglu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Optimization of a multigene biochip for detection of relapsed and early relapsed colorectal cancer

(2017) Yu-Tang Chang et al.   JOURNAL OF SURGICAL RESEARCH

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition

(2017) P Dietrich et al.   ONCOGENE

Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option

(2017) Peter Dietrich et al.   Oncotarget

Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation

(2017) Ping Wang et al.   Stem Cell Research & Therapy

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site

(2016) Sandip Murarka et al.   CHEMISTRY-A EUROPEAN JOURNAL

TGFβ signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells

(2016) Nathan Ungerleider et al.   MOLECULAR CARCINOGENESIS

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

(2016) Srisathiyanarayanan Dharmaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of pyrazolopyridazinones as PDEδ inhibitors

(2016) Björn Papke et al.   Nature Communications

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner

(2016) Nirmal Dutta et al.   Biology Open

Molecular Mechanism and Prediction of Sorafenib Chemoresistance in Human Hepatocellular Carcinoma

(2015) Naoshi Nishida et al.   DIGESTIVE DISEASES

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

(2014) Peter Dietrich et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Transforming Growth Factor-  as a Therapeutic Target in Hepatocellular Carcinoma

(2014) G. Giannelli et al.   CANCER RESEARCH

KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport

(2014) Malte Schmick et al.   CELL

A RAS Renaissance: Emerging Targeted Therapies for KRAS-Mutated Non-Small Cell Lung Cancer

(2014) N. Vasan et al.   CLINICAL CANCER RESEARCH

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

siPools: highly complex but accurately defined siRNA pools eliminate off-target effects

(2014) Michael Hannus et al.   NUCLEIC ACIDS RESEARCH

Strong reduction of AGO2 expression in melanoma and cellular consequences

(2013) D Völler et al.   BRITISH JOURNAL OF CANCER

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Comparative Analysis of TGF-β/Smad Signaling Dependent Cytostasis in Human Hepatocellular Carcinoma Cell Lines

(2013) Johanna Dzieran et al.   PLoS One

Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity

(2013) R Bauer et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Isolation of Human Hepatocytes by a Two-step Collagenase Perfusion Procedure

(2013) Serene M.L. Lee et al.   Jove-Journal of Visualized Experiments

Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells

(2013) Hongli Dong et al.   SpringerPlus

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

(2010) S. Roessler et al.   CANCER RESEARCH

miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway

(2010) Fu Yang et al.   HEPATOLOGY

Identifying Genes for Establishing a Multigenic Test for Hepatocellular Carcinoma Surveillance in Hepatitis C Virus-Positive Cirrhotic Patients

(2009) K. J. Archer et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

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(2009) Valeria Mas et al.   MOLECULAR MEDICINE

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

(2009) S. Kosugi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor-β gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

(2008) Cédric Coulouarn et al.   HEPATOLOGY

Molecular mechanisms of hepatocellular carcinoma

(2008) Rajagopal N. Aravalli et al.   HEPATOLOGY

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE