Role of Extracellular Vesicles (EVs) in Cell Stress Response and Resistance to Cancer Therapy

Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma

(2018) Kumiko Shiozawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Can hi-jacking hypoxia inhibit extracellular vesicles in cancer?

(2018) Michelle C. Lowry et al.   DRUG DISCOVERY TODAY

Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6

(2018) Danfeng Guo et al.   IMMUNOLOGY

Exosomes from Irradiated Nonsmall Cell Lung Cancer Cells Reduced Sensitivity of Recipient Cells to Anaplastic Lymphoma Kinase Inhibitors

(2018) Hao Wu et al.   MOLECULAR PHARMACEUTICS

Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

(2018) Ya-Ling Hsu et al.   MOLECULAR THERAPY

Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

(2018) Wenshuo Wang et al.   Advanced Healthcare Materials

The interplay between exosomes and autophagy – partners in crime

(2018) Jing Xu et al.   JOURNAL OF CELL SCIENCE

Exosomes produced from three-dimensional cultures of mesenchymal stem cells by tangential flow filtration show higher yield and improved activity

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method

(2018) Gabriella Andriolo et al.   Frontiers in Physiology

A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

(2018) Giulia Cesi et al.   Molecular Cancer

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

(2018) Ioanna Keklikoglou et al.   NATURE CELL BIOLOGY

Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications

(2017) Emerence Crompot et al.   HAEMATOLOGICA

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

(2017) Peiming Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer

(2017) Kuan Ning et al.   JOURNAL OF SURGICAL ONCOLOGY

Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo

(2017) Céline Bouvy et al.   LEUKEMIA RESEARCH

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

(2017) Akira Yokoi et al.   Nature Communications

Exosomes as mediators of platinum resistance in ovarian cancer

(2017) Jennifer Crow et al.   Oncotarget

Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis

(2017) Ning Wang et al.   Theranostics

Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications

(2017) Emerence Crompot et al.   HAEMATOLOGICA

Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions

(2017) Jeng-Yuan Shiau et al.   Frontiers in Pharmacology

Autophagy-Regulating microRNAs and Cancer

(2017) Devrim Gozuacik et al.   Frontiers in Oncology

Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

(2017) Vanessa Lopes-Rodrigues et al.   Scientific Reports

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress

(2016) Soshi Kanemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype

(2016) Ling Li et al.   CANCER RESEARCH

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Multimodal transfer of MDR by exosomes in human osteosarcoma

(2016) ELENA TORREGGIANI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer

(2016) Xiaohong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Role of CD44 and ERM Proteins in Expression and Functionality of P-glycoprotein in Breast Cancer Cells

(2016) Deep Pokharel et al.   MOLECULES

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma

(2016) Li Zhang et al.   Oncotarget

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance

(2016) Bridget Kreger et al.   Cancers

Mesenchymal Stem/Stromal Cells under Stress Increase Osteosarcoma Migration and Apoptosis Resistance via Extracellular Vesicle Mediated Communication

(2016) Krishna C. Vallabhaneni et al.   PLoS One

Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma

(2015) Karol Jelonek et al.   ACTA BIOCHIMICA POLONICA

Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer

(2015) Runbi Ji et al.   CELL CYCLE

Increased anti-tumour activity by exosomes derived from doxorubicin-treated tumour cells via heat stress

(2015) Yunshan Yang et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

(2015) Laura Montermini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast cancer resistance protein (BCRP)-containing circulating microvesicles contribute to chemoresistance in breast cancer

(2015) YUN CHEN et al.   Oncology Letters

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

(2015) Isabel R. Schlaepfer et al.   Oncotarget

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

(2015) Krishna C. Vallabhaneni et al.   Oncotarget

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells

(2015) Claudia Campanella et al.   Oncotarget

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

(2015) Guy Berchem et al.   OncoImmunology

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

(2015) Dhruv Kumar et al.   Oncotarget

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic  -cell Dysfunction

(2014) N. Javeed et al.   CLINICAL CANCER RESEARCH

Modulation of hypoxia-signaling pathways by extracellular linc-RoR

(2014) K. Takahashi et al.   JOURNAL OF CELL SCIENCE

Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy

(2014) Kenji Takahashi et al.   MOLECULAR CANCER RESEARCH

Interactions between Exosomes from Breast Cancer Cells and Primary Mammary Epithelial Cells Leads to Generation of Reactive Oxygen Species Which Induce DNA Damage Response, Stabilization of p53 and Autophagy in Epithelial Cells

(2014) Sujoy Dutta et al.   PLoS One

GAIP Interacting Protein C-Terminus Regulates Autophagy and Exosome Biogenesis of Pancreatic Cancer through Metabolic Pathways

(2014) Santanu Bhattacharya et al.   PLoS One

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance

(2014) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer

(2014) Kenji Takahashi et al.   FEBS Open Bio

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

(2013) Keith O’Brien et al.   EUROPEAN JOURNAL OF CANCER

Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

(2013) Hiroko Tadokoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes

(2012) Claire Corcoran et al.   PLoS One

Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients

(2011) Haijun Zhong et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Secretion of annexin A3 from ovarian cancer cells and its association with platinum resistance in ovarian cancer patients

(2011) Jie Yin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine

(2011) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

(2011) Malin Hedlund et al.   PLoS One

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

(2011) T. Aung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA