Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression

PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytes

(2016) Matthew W Rosenbaum et al.   MODERN PATHOLOGY

Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells

(2016) Diego Sánchez-Martínez et al.   Frontiers in Immunology

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

(2015) Ariane Giannattasio et al.   BMC CANCER

Ultrasonic three-dimensional on-chip cell culture for dynamic studies of tumor immune surveillance by natural killer cells

(2015) Athanasia E. Christakou et al.   LAB ON A CHIP

Therapeutic Potential and Challenges of Natural Killer Cells in Treatment of Solid Tumors

(2015) Andrea Gras Navarro et al.   Frontiers in Immunology

Human NK cells activated by EBV+lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells

(2015) Diego Sánchez-Martínez et al.   OncoImmunology

All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity

(2014) Diego Sanchez-Martínez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Going back to class I: MHC and immunotherapies for childhood cancer

(2014) Kellie B. Haworth et al.   PEDIATRIC BLOOD & CANCER

NK-cell-dependent killing of colon carcinoma cells is mediated by natural cytotoxicity receptors (NCRs) and stimulated by parvovirus infection of target cells

(2013) Rauf Bhat et al.   BMC CANCER

NK cell-based immunotherapy for malignant diseases

(2013) Min Cheng et al.   Cellular & Molecular Immunology

Human NK Cells Selective Targeting of Colon Cancer-Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules

(2013) R. Tallerico et al.   JOURNAL OF IMMUNOLOGY

Recombinant production of human ICAM-1 chimeras by single step on column refolding and purification

(2013) David Núñez et al.   PROCESS BIOCHEMISTRY

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells

(2013) Franco Locatelli et al.   Frontiers in Immunology

NK Cells—From Bench to Clinic

(2012) William J. Murphy et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Natural killer cell alloreactivity 10 years later

(2012) Andrea Velardi   CURRENT OPINION IN HEMATOLOGY

Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines

(2011) N. Halama et al.   CLINICAL CANCER RESEARCH

Natural Killer Cells and Solid Tumors

(2011) Ana Stojanovic et al.   Journal of Innate Immunity

Natural Killer Cells Preferentially Target Cancer Stem Cells; Role of Monocytes in Protection Against NK Cell Mediated Lysis of Cancer Stem Cells

(2011) Anahid Jewett et al.   Current Drug Delivery

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

A Human NK Cell Activation/Inhibition Threshold Allows Small Changes in the Target Cell Surface Phenotype To Dramatically Alter Susceptibility to NK Cells

(2010) T. D. Holmes et al.   JOURNAL OF IMMUNOLOGY

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors

(2009) Y. T. Bryceson et al.   BLOOD

Expansion and Activation of Natural Killer Cells for Cancer Immunotherapy

(2009) Duck Cho et al.   Korean Journal of Laboratory Medicine

Can NK cells be a therapeutic target in human diseases?

(2008) Christopher J. Chan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural killer cell recognition of missing self

(2008) Klas Kärre   NATURE IMMUNOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE