Deregulation of Circular RNAs in Cancer From the Perspectives of Aberrant Biogenesis, Transport and Removal

The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases

(2018) Stępień E et al.   ACTA PHARMACOLOGICA SINICA

Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells

(2018) Guang-Feng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing

(2018) Meilin Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The emerging role of circRNAs and their clinical significance in human cancers

(2018) Ling Qian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Circular RNAs as novel rising stars with huge potentials in development and disease

(2018) Jian Zhou et al.   Cancer Biomarkers

Epigenetic and epitranscriptomic changes in colorectal cancer: Diagnostic, prognostic, and treatment implications

(2018) Elisa Porcellini et al.   CANCER LETTERS

A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

(2018) Benjamin Kleaveland et al.   CELL

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

(2018) Ling Fang et al.   CELL DEATH AND DIFFERENTIATION

Circ-ANAPC7 is Upregulated in Acute Myeloid Leukemia and Appears to Target the MiR-181 Family

(2018) Hongli Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

circRNAs in Cancer

(2018) Ines Lucia Patop et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The mechanism and function of circular RNAs in human diseases

(2018) Kexin Lei et al.   EXPERIMENTAL CELL RESEARCH

Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer

(2018) Mingshan Li et al.   GENE

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs

(2018) Chuan Huang et al.   GENES & DEVELOPMENT

Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs

(2018) Yao Wan et al.   GENES & DEVELOPMENT

Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis

(2018) Honglei Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

(2018) Jian Yu et al.   JOURNAL OF HEPATOLOGY

Chromatin organisation and cancer prognosis: a pan-cancer study

(2018) Andreas Kleppe et al.   LANCET ONCOLOGY

Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas

(2018) S Begum et al.   ONCOGENE

Circular RNAs: biogenesis, expression and their potential roles in reproduction

(2018) Guobo Quan et al.   Journal of Ovarian Research

Circular RNA CpG island hypermethylation-associated silencing in human cancer

(2018) Humberto J. Ferreira et al.   Oncotarget

Circular RNA Myosin Light Chain Kinase (MYLK) Promotes Prostate Cancer Progression through Modulating Mir-29a Expression

(2018) Yuanqing Dai et al.   MEDICAL SCIENCE MONITOR

Circular RNAs in Cancer – Lessons Learned From microRNAs

(2018) Mihnea Dragomir et al.   Frontiers in Oncology

Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response

(2018) Yusheng Wu et al.   EMBO JOURNAL

Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer

(2018) Shuangyan Tan et al.   Molecular Cancer

The Biogenesis, Functions, and Challenges of Circular RNAs

(2018) Xiang Li et al.   MOLECULAR CELL

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

(2018) Benoit P Nicolet et al.   NUCLEIC ACIDS RESEARCH

Circular DNA tumor viruses make circular RNAs

(2018) Tuna Toptan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes

(2018) Yajun Chen et al.   CELL DEATH AND DIFFERENTIATION

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

(2018) Maolei Zhang et al.   Nature Communications

circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide

(2018) Chaohui Gu et al.   Molecular Therapy-Nucleic Acids

The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs

(2017) Roland Jacob et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

An Unchartered Journey for Ribosomes: Circumnavigating Circular RNAs to Produce Proteins

(2017) Deirdre C. Tatomer et al.   MOLECULAR CELL

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

(2017) Xiang Li et al.   MOLECULAR CELL

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

(2017) Tuğçe Aktaş et al.   NATURE

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Profiling and bioinformatic analysis of circular RNA expression regulated by c-Myc

(2017) Qiheng Gou et al.   Oncotarget

Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology

(2017) Adam M. Schmitt et al.   Cold Spring Harbor Perspectives in Medicine

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

(2017) Yibing Yang et al.   JNCI-Journal of the National Cancer Institute

Circular RNAs (circRNAs) in Health and Disease

(2017) et al.   Genes

A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis

(2016) Aruo Nan et al.   ARCHIVES OF TOXICOLOGY

Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma

(2016) Marie-Pier Tremblay et al.   BMC GENOMICS

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

(2016) Jlenia Guarnerio et al.   CELL

CircRNA-derived pseudogenes

(2016) Rui Dong et al.   CELL RESEARCH

An Ectopic Network of Transcription Factors Regulated by Hippo Signaling Drives Growth and Invasion of a Malignant Tumor Model

(2016) Mardelle Atkins et al.   CURRENT BIOLOGY

Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers

(2016) Lian Mignacca et al.   CYTOKINE

Circular RNAs: analysis, expression and potential functions

(2016) Steven P. Barrett et al.   DEVELOPMENT

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs

(2016) Xiao-Ou Zhang et al.   GENOME RESEARCH

Defective control of pre–messenger RNA splicing in human disease

(2016) Benoit Chabot et al.   JOURNAL OF CELL BIOLOGY

Noncoding RNAs: Regulators of the Mammalian Transcription Machinery

(2016) Tess M. Eidem et al.   JOURNAL OF MOLECULAR BIOLOGY

m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome

(2016) Benoit Molinie et al.   NATURE METHODS

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Tumor cell survival dependence on the DHX9 DExH-box helicase

(2016) T Lee et al.   ONCOGENE

Increased complexity of circRNA expression during species evolution

(2016) Rui Dong et al.   RNA Biology

Linking Long Noncoding RNA Localization and Function

(2016) Ling-Ling Chen   TRENDS IN BIOCHEMICAL SCIENCES

Comprehensive identification of internal structure and alternative splicing events in circular RNAs

(2016) Yuan Gao et al.   Nature Communications

The Biogenesis of Nascent Circular RNAs

(2016) Yang Zhang et al.   Cell Reports

Emerging functions of the Quaking RNA-binding proteins and link to human diseases

(2016) Lama Darbelli et al.   Wiley Interdisciplinary Reviews-RNA

Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance

(2016) Erika Lasda et al.   PLoS One

CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs

(2016) Tim Schneider et al.   Scientific Reports

Intron retention in mRNA: No longer nonsense

(2015) Justin J.-L. Wong et al.   BIOESSAYS

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

The role of Alu elements in the cis-regulation of RNA processing

(2015) Chammiran Daniel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Combinatorial control ofDrosophilacircular RNA expression by intronic repeats, hnRNPs, and SR proteins

(2015) Marianne C. Kramer et al.   GENES & DEVELOPMENT

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Intron retention is a widespread mechanism of tumor-suppressor inactivation

(2015) Hyunchul Jung et al.   NATURE GENETICS

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis

(2015) W Yang et al.   ONCOGENE

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

Regulation of circRNA biogenesis

(2015) Ling-Ling Chen et al.   RNA Biology

Circular RNAs remain peculiarly unclear in biogenesis and function

(2015) Liang Chen et al.   Science China-Life Sciences

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rolling Circle Translation of Circular RNA in Living Human Cells

(2015) Naoko Abe et al.   Scientific Reports

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development

(2015) Linda Szabo et al.   GENOME BIOLOGY

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Circular RNA Is Expressed across the Eukaryotic Tree of Life

(2014) Peter L. Wang et al.   PLoS One

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

(2014) Feng-Yang Zong et al.   PLoS Genetics

The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

(2013) Ying Ge et al.   BIOESSAYS

A Transcriptome-wide Atlas of RNP Composition Reveals Diverse Classes of mRNAs and lncRNAs

(2013) Alex Charles Tuck et al.   CELL

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Mutation at Intronic Repeats of the Ataxia-Telangiectasia Mutated (ATM) Gene and ATM Protein Loss in Primary Gastric Cancer with Microsatellite Instability

(2013) Hee Sung Kim et al.   PLoS One

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

RNA polymerase II transcription: Structure and mechanism

(2012) Xin Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Co-transcriptional splicing of constitutive and alternative exons

(2009) A. Pandya-Jones et al.   RNA