Emerging functions of the Quaking RNA-binding proteins and link to human diseases

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

(2016) Pratiti Bandopadhayay et al.   NATURE GENETICS

Genome-wide analysis of alternative transcripts in human breast cancer

(2015) Ji Wen et al.   BREAST CANCER RESEARCH AND TREATMENT

Circular RNA: A new star of noncoding RNAs

(2015) Shibin Qu et al.   CANCER LETTERS

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

QKI-5 suppresses cyclin D1 expression and proliferation of oral squamous cell carcinoma cells via MAPK signalling pathway

(2015) X. Fu et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma

(2015) Hui Wang et al.   Molecular Cancer

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Identification of recurrent regulated alternative splicing events across human solid tumors

(2015) Miri Danan-Gotthold et al.   NUCLEIC ACIDS RESEARCH

Quaking and miR-155 interactions in inflammation and leukemogenesis

(2015) Esmerina Tili et al.   Oncotarget

QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2

(2014) Wei Lu et al.   CANCER BIOLOGY & THERAPY

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

QKI deficiency promotes FoxO1 mediated nitrosative stress and endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart

(2014) Wangang Guo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

MicroRNA-155 promotes the proliferation and invasion abilities of colon cancer cells by targeting quaking

(2014) BIN HE et al.   Molecular Medicine Reports

Post-transcriptional repression of FOXO1 by QKI results in low levels of FOXO1 expression in breast cancer cells

(2014) FANG YU et al.   ONCOLOGY REPORTS

Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors

(2014) Jacquelyn J. Roth et al.   Cancer Genetics

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

(2014) Feng-Yang Zong et al.   PLoS Genetics

The tumor suppressing effects of QKI-5 in prostate cancer

(2013) Yi Zhao et al.   CANCER BIOLOGY & THERAPY

Quaking, an RNA-Binding Protein, Is a Critical Regulator of Vascular Smooth Muscle Cell Phenotype

(2013) Eric P. van der Veer et al.   CIRCULATION RESEARCH

Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites

(2013) M. Teplova et al.   GENES & DEVELOPMENT

The QKI-5 and QKI-6 RNA Binding Proteins Regulate the Expression of MicroRNA 7 in Glial Cells

(2013) Yunling Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

(2013) L. A. Ramkissoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation

(2013) M. P. Hall et al.   RNA

Tumor microenvironment-associated modifications of alternative splicing

(2013) J.-P. Brosseau et al.   RNA

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis

(2012) Yongqian Bian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA

(2012) A.-J. Chen et al.   GENES & DEVELOPMENT

miR-574-5p negatively regulatesQki6/7to impactβ-catenin/Wnt signalling and the development of colorectal cancer

(2012) Shunlong Ji et al.   GUT

Structural Analysis of the Quaking Homodimerization Interface

(2012) Christine Beuck et al.   JOURNAL OF MOLECULAR BIOLOGY

The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation

(2012) Haiyan Fu et al.   MOLECULAR BIOLOGY OF THE CELL

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation

(2011) Guodong Yang et al.   CELL CYCLE

RNA Binding Protein QKI Inhibits the Ischemia/reperfusion-induced Apoptosis in Neonatal Cardiomyocytes

(2011) Wangang Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quaking Regulates Hnrnpa1 Expression through Its 3′ UTR in Oligodendrocyte Precursor Cells

(2011) N. Ruth Zearfoss et al.   PLoS Genetics

Haploinsufficiency of the gene Quaking (QKI) is associated with the 6q terminal deletion syndrome

(2010) Liesbeth Backx et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

The QKI-6 RNA Binding Protein Regulates Actin-interacting Protein-1 mRNA Stability during Oligodendrocyte Differentiation

(2010) Evgueni Doukhanine et al.   MOLECULAR BIOLOGY OF THE CELL

Aberrant regulation of alternative pre-mRNA splicing in schizophrenia

(2010) Tomomi Morikawa et al.   NEUROCHEMISTRY INTERNATIONAL

QKI-7 Regulates Expression of Interferon-Related Genes in Human Astrocyte Glioma Cells

(2010) Lin Jiang et al.   PLoS One

The QKI-6 RNA Binding Protein Localizes with the MBP mRNAs in Stress Granules of Glial Cells

(2010) Yunling Wang et al.   PLoS One

RNA-Binding Protein Quaking, a Critical Regulator of Colon Epithelial Differentiation and a Suppressor of Colon Cancer

(2009) Guodong Yang et al.   GASTROENTEROLOGY

High-Resolution Genomic Copy Number Profiling of Glioblastoma Multiforme by Single Nucleotide Polymorphism DNA Microarray

(2009) D. Yin et al.   MOLECULAR CANCER RESEARCH

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL