Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism

Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling

(2018) Joshua V. Troll et al.   DEVELOPMENT

Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome

(2018) Kellie Cloney et al.   FEBS Journal

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations

(2018) Silvia De Rubeis et al.   Molecular Autism

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway

(2017) Shu-Chen Wei et al.   INFLAMMATORY BOWEL DISEASES

Evolution of complexity in the zebrafish synapse proteome

(2017) Àlex Bayés et al.   Nature Communications

The enteric nervous system promotes intestinal health by constraining microbiota composition

(2017) Annah S. Rolig et al.   PLOS BIOLOGY

Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3

(2017) Stefanie Pfaender et al.   Scientific Reports

Integrative Control of Gastrointestinal Motility by Nitric Oxide

(2016) Dieter Groneberg et al.   CURRENT MEDICINAL CHEMISTRY

Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish

(2016) Chun-xue Liu et al.   DEVELOPMENT GENES AND EVOLUTION

The zebrafish as a model to study intestinal inflammation

(2016) Sylvia Brugman   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Gustatory and general visceral centers and their connections in the brain of adult zebrafish: a carbocyanine dye tract-tracing study

(2016) Julián Yáñez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Zebrafish: A Translational Model System for Studying Neuropsychiatric Disorders

(2016) Sundas Ijaz et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

(2016) Rui T Peixoto et al.   NATURE NEUROSCIENCE

Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2

(2016) Ellen J. Hoffman et al.   NEURON

Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota

(2016) Travis J Wiles et al.   PLOS BIOLOGY

Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish

(2016) Robert A. Kozol et al.   Frontiers in Molecular Neuroscience

Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

(2016) Andromeda Linan-Rico et al.   Frontiers in Neuroscience

Functional Loss of Semaphorin 3C and/or Semaphorin 3D and Their Epistatic Interaction with Ret Are Critical to Hirschsprung Disease Liability

(2015) Qian Jiang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pitt-Hopkins Mouse Model has Altered Particular Gastrointestinal Transits In Vivo

(2015) Vladimir Grubišić et al.   Autism Research

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Mutations in RAD21 Disrupt Regulation of APOB in Patients With Chronic Intestinal Pseudo-Obstruction

(2015) Elena Bonora et al.   GASTROENTEROLOGY

Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

(2015) Robert A. Kozol et al.   HUMAN MOLECULAR GENETICS

Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder

(2015) Alexander J Abrams et al.   NATURE GENETICS

The zebrafish mutantlessen: an experimental model for congenital enteric neuropathies

(2015) L. Uyttebroek et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Association of Maternal Report of Infant and Toddler Gastrointestinal Symptoms With Autism

(2015) Michaeline Bresnahan et al.   JAMA Psychiatry

Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology

(2015) Kirsteen N. Browning   Frontiers in Neuroscience

The stomach–brain axis

(2014) Gerald Holtmann et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

(2014) Raphael Bernier et al.   CELL

Clinical and genomic evaluation of 201 patients with Phelan–McDermid syndrome

(2014) Sara M. Sarasua et al.   HUMAN GENETICS

Whole-genome duplication in teleost fishes and its evolutionary consequences

(2014) Stella M. K. Glasauer et al.   MOLECULAR GENETICS AND GENOMICS

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

(2014) Tessa G. Montague et al.   NUCLEIC ACIDS RESEARCH

Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance

(2014) Mohtashem Samsam   WORLD JOURNAL OF GASTROENTEROLOGY

Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish

(2014) Jui-Yi Hsieh et al.   Frontiers in Neural Circuits

Gastrointestinal Issues in Autism Spectrum Disorder

(2014) Elaine Y Hsiao   HARVARD REVIEW OF PSYCHIATRY

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

(2014) Xiaoming Wang et al.   Molecular Autism

Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

(2013) Stefanie Grabrucker et al.   BRAIN

Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility

(2013) Gillian Roach et al.   DEVELOPMENTAL BIOLOGY

A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders

(2013) Andreas M. Grabrucker   Developmental Neurobiology

Identification of two novelShank3transcripts in the developing mouse neocortex

(2013) Chikako Waga et al.   JOURNAL OF NEUROCHEMISTRY

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Distinct phenotypes in zebrafish models of human startle disease

(2013) Lisa R. Ganser et al.   NEUROBIOLOGY OF DISEASE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Characterization of Enteric Neurons in Wild-Type and Mutant Zebrafish Using Semi-Automated Cell Counting and Co-Expression Analysis

(2013) Levi W. Simonson et al.   Zebrafish

Kit Signaling Is Required for Development of Coordinated Motility Patterns in Zebrafish Gastrointestinal Tract

(2013) Adam Rich et al.   Zebrafish

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

SHANK3 haploinsufficiency: a “common” but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders

(2013) Catalina Betancur et al.   Molecular Autism

Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

(2013) Latha Soorya et al.   Molecular Autism

Generation of Multiple Classes of V0 Neurons in Zebrafish Spinal Cord: Progenitor Heterogeneity and Temporal Control of Neuronal Diversity

(2012) C. Satou et al.   JOURNAL OF NEUROSCIENCE

Zebrafish Agr2 Is Required for Terminal Differentiation of Intestinal Goblet Cells

(2012) Yi-Chung Chen et al.   PLoS One

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Neurochemical coding of enteric neurons in adult and embryonic zebrafish (Danio rerio)

(2010) Leen Uyttebroek et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives

(2010) Laura de Magistris et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)—scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system

(2010) M. Raab et al.   NEUROSCIENCE

Role of serotonin in gastrointestinal motility and irritable bowel syndrome

(2009) Arbab Sikander et al.   CLINICA CHIMICA ACTA

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements

(2009) Alan Huett et al.   EXPERIMENTAL CELL RESEARCH

Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish

(2009) h. a. field et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Development of enteric and vagal innervation of the zebrafish (Danio rerio) gut

(2008) Catharina Olsson et al.   JOURNAL OF COMPARATIVE NEUROLOGY