Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease—A Novel Target for Treatment

Vascular ossification: Pathology, mechanisms, and clinical implications

(2018) Michael A. Fuery et al.   BONE

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

(2018) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

Plaque Calcification During Atherosclerosis Progression and Regression

(2018) Atsushi Shioi et al.   Journal of Atherosclerosis and Thrombosis

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

(2018) Sundeep Khosla et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function

(2018) Lucie Hénaut et al.   Toxins

Role of Uremic Toxins for Kidney, Cardiovascular, and Bone Dysfunction

(2018) Hideki Fujii et al.   Toxins

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells

(2018) Suvi M. Kuosmanen et al.   Redox Biology

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro

(2018) Björn Hegner et al.   Scientific Reports

Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease

(2018) Hideyuki Mukai et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

(2018) Gabor A. Fulop et al.   GeroScience

Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells

(2017) Li Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vascular calcification in chronic kidney disease: different bricks in the wall?

(2017) Marc Vervloet et al.   KIDNEY INTERNATIONAL

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

The role of epigenetics in renal ageing

(2017) Paul G. Shiels et al.   Nature Reviews Nephrology

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease

(2017) Wen-Juan Wang et al.   Oncotarget

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age

(2017) Gretel Gisela Pellegrini et al.   PLoS One

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Vertebral bone density associates with coronary artery calcification and is an independent predictor of poor outcome in end-stage renal disease patients

(2016) Zhimin Chen et al.   BONE

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

(2016) Giuseppe Maltese et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Does Vascular Calcification Accelerate Inflammation?

(2016) Francis R. Joshi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chronic Inflammation: Accelerator of Biological Aging

(2016) Bertrand Fougère et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

Identification of Molecular Markers of Delayed Graft Function Based on the Regulation of Biological Ageing

(2016) Dagmara McGuinness et al.   PLoS One

Therapeutics targeting persistent inflammation in chronic kidney disease

(2016) Anna Machowska et al.   Translational Research

Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2

(2016) P. Zhang et al.   TRANSPLANTATION PROCEEDINGS

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2015) Martin Bennett et al.   CIRCULATION

High dose and long-term statin therapy accelerate coronary artery calcification

(2015) Michael Henein et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Segmental differences in the orientation of smooth muscle cells in the tunica media of porcine aortae

(2014) Zbynek Tonar et al.   Biomechanics and Modeling in Mechanobiology

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

(2014) Y Hassona et al.   BRITISH JOURNAL OF CANCER

Resveratrol Supplementation Reduces Aortic Atherosclerosis and Calcification and Attenuates Loss of Aerobic Capacity in a Mouse Model of Uremia

(2014) Emily J. Tomayko et al.   JOURNAL OF MEDICINAL FOOD

Chronic kidney disease and premature ageing

(2014) Jeroen P. Kooman et al.   Nature Reviews Nephrology

Activation of Nrf2 by dimethyl fumarate improves vascular calcification

(2014) Chae-Myeong Ha et al.   VASCULAR PHARMACOLOGY

Characterization of novel markers of senescence and their prognostic potential in cancer

(2014) M Althubiti et al.   Cell Death & Disease

Chronic Kidney Disease: A Clinical Model of Premature Aging

(2013) Peter Stenvinkel et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Vascular calcification in end-stage renal disease

(2013) Kristen L. Jablonski et al.   Hemodialysis International

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

(2013) Catherine M. Shanahan   Nature Reviews Nephrology

Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component of Donor Scoring Criteria

(2013) Marc Gingell-Littlejohn et al.   PLoS One

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Macrophages play a unique role in the plaque calcification by enhancing the osteogenic signals exerted by vascular smooth muscle cells

(2012) Koji Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Arterial Matrix Metalloproteinases Leads to Vascular Calcification in Chronic Kidney Disease

(2011) Neal X. Chen et al.   AMERICAN JOURNAL OF NEPHROLOGY

Vascular Calcification

(2011) Jason C. Kovacic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Improving Precision in Investigating Aging: Why Telomeres Can Cause Problems

(2010) P. G. Shiels   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification

(2009) Dominick G.A. Burton et al.   EXPERIMENTAL GERONTOLOGY

Vascular Calcification: The Killer of Patients with Chronic Kidney Disease

(2009) M. Mizobuchi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cyclin-dependent kinase inhibitor p16INK4a and telomerase may co-modulate endothelial progenitor cells senescence

(2008) De-Guang Yang et al.   AGEING RESEARCH REVIEWS

Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation

(2008) Christian Koppelstaetter et al.   AGING CELL

Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis

(2008) Rukshana C. Shroff et al.   CIRCULATION

Media Calcification and Intima Calcification Are Distinct Entities in Chronic Kidney Disease

(2008) K. Amann   Clinical Journal of the American Society of Nephrology