Article
Immunology
Jiyue Wu, Feilong Zhang, Xiang Zheng, Jiandong Zhang, Peng Cao, Zejia Sun, Wei Wang
Summary: This study identified two distinct clusters based on NET-related genes during the ischemia reperfusion injury (IRI) process in renal transplantation. Robust prediction strategies for delayed graft function (DGF) and long-term graft survival were constructed. The findings provide references for early prevention and individualized treatment of postoperative complications after renal transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xiangling Wei, Weiming Deng, Zhanwen Dong, Zhenwei Xie, Jinhua Zhang, Ruojiao Wang, Rui Zhang, Ning Na, Yu Zhou
Summary: This study identified subtypes of renal ischemia-reperfusion injury (IRI) and constructed a predictive signature for delayed graft function (DGF) based on ferroptosis-related genes (FRGs). The study found two ferroptosis-related patient clusters based on the expression patterns of BECN1 and NF2 gene clusters. Additionally, a six-gene ferroptosis-associated signature was constructed to predict the occurrence of DGF in renal IRI patients. These findings have important implications for patient stratification and prevention of DGF in kidney transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Cullan Donnelly, Maria Keller, Liise Kayler
Summary: The study found that prolonged DGF lasting over 20 days indicates a significantly higher risk for reduced eGFR at 1 year compared to lesser degrees of DGF, thus serving as a threshold indicator of increased risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Joseba Salguero, Laura Chamorro, Enrique Gomez-Gomez, Patricia de Benito, Jose E. Robles, Juan P. Campos
Summary: Delayed graft function (DGF) development significantly contributes to graft loss in kidney transplants, particularly in grafts with KDRI >= 1.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Bernard Srour, Lucas Cory Hynes, Theron Johnson, Tilman Kuehn, Verena A. Katzke, Rudolf Kaaks
Summary: This study investigated the predictive ability of five serum markers of biological ageing on long-term mortality risk and life expectancy in middle-aged and older men and women. The results showed that including these serum markers in the model improved the accuracy of predicting individual life expectancy differences and helped identify high-risk individuals.
Article
Multidisciplinary Sciences
Caterina Dolla, Alberto Mella, Giacinta Vigilante, Fabrizio Fop, Anna Allesina, Roberto Presta, Aldo Verri, Paolo Gontero, Fabio Gobbi, Roberto Balagna, Roberta Giraudi, Luigi Biancone
Summary: The study suggests that pre-existing chronic hypotension may be associated with delayed graft function and could have a significant detrimental impact on organ transplant survival, especially when elderly donors are involved in the procedure.
Article
Geriatrics & Gerontology
Rikke S. Kamper, Julian Alcazar, Lars L. Andersen, Bryan Haddock, Niklas Rye Jorgensen, Peter Hovind, Charlotte Suetta
Summary: The study investigated the relationship between chronic low-grade inflammation and age-related muscle decline and physical performance. Results showed that with age, levels of certain inflammatory biomarkers in the blood increased significantly, correlating with decreased muscle strength and physical function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Transplantation
Eva Schrezenmeier, Mia Mueller, Frank Friedersdorff, Dmytro Khadzhynov, Fabian Halleck, Oliver Staeck, Michael Durr, Kun Zhang, Kai-Uwe Eckardt, Klemens Budde, Lukas J. Lehner
Summary: This study analyzed the severity of delayed graft function (DGF) and its impact on transplant outcomes in 627 deceased-donor kidney transplant recipients. The results showed that the duration of DGF had a significant effect on 10-year death-censored graft survival, especially in kidneys with a Kidney Donor Profile Index (KDPI) less than 85%. However, short duration DGF (0-1 day) had comparable results to no DGF.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Chemistry, Multidisciplinary
Hong Cai, Yu-Xin Wu, Zhou Lu, Dong Luo, Jing-Xuan Sun, Guang-Wei Wu, Mian Li, Yu-Bai Wei, Li-Ming Zhong, Dan Li
Summary: This study successfully prepared a bioinspired metal-organic framework and observed amino acid encapsulation for the first time through single-crystal X-ray diffraction. Molecular dynamics and density functional theory investigation revealed the role of hydrogen bonding and pi-pi/C-H center dot center dot center dot pi interactions in the host-guest interface.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Pharmacology & Pharmacy
Wieteke Kleinherenbrink, Marije Baas, Gizal Nakhsbandi, Dennis A. Hesselink, Joke Roodnat, Brenda C. de Winter, Luuk Hilbrands, Teun van Gelder
Summary: The study found that delayed graft function and rejection significantly increased the risk of CMV disease in renal transplant recipients. Valganciclovir prophylaxis may not provide sufficient protection for CMV IgG-seronegative recipients receiving a kidney from CMV IgG-seropositive donor, especially those with delayed graft function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Plant Sciences
Laura Cuyas, Pascale David, Damien de Craieye, Sophia Ng, Mustapha Arkoun, Claude Plassard, Mohamadi Faharidine, Delphine Hourcade, Francesca Degan, Sylvain Pluchon, Laurent Nussaume
Summary: By conducting transcriptomic studies in the model plant Arabidopsis thaliana, we identified conserved molecular markers for Pi starvation in early roots or leaves that respond rapidly to changes in phosphate nutritional status. We found their homologues in three crops and demonstrated their reliability in monitoring the plant's internal Pi status. These markers provide valuable tools for plant physiologists and breeders to assess the impact of phosphate bio-availability on plant growth.
Article
Chemistry, Physical
Jeongbin Park, Jinyeong Choi, Jae Eun Lee, Hongyoon Choi, Hyung-Jun Im
Summary: A molecular marker identification platform was developed to explore the factors associated with nanomedicine tumor uptake. By integrating microscopic fluorescence images with spatial transcriptomics information, molecular markers related to hypoxia, glycolysis, and apoptosis were identified as being associated with the intratumoral distribution of PEGylated liposomes. This method can be applied to explain the distribution of a wide range of nanomedicines and enhance their precise utilization.
Article
Biochemistry & Molecular Biology
Zhongcheng Yang, Zhijun Cao, Wenxin Wang, Ya Chen, Wanqiu Huang, Shixuan Jiao, Siliang Chen, Lianru Chen, Yuxia Liu, Jianming Mao, Luyong Zhang, Zheng Li
Summary: Human carboxylesterase 2 (hCES2A) is an important serine hydrolase responsible for the hydrolysis of prodrugs and esters. Inhibition of hCES2A can alleviate the side effects of certain drugs, such as irinotecan-induced delayed diarrhea. The compound LK-44 was identified as a potent and selective inhibitor of hCES2A, and it showed promising results in reducing the side effects of irinotecan-induced diarrhea in vivo.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Paola Pontrelli, Simona Simone, Federica Rascio, Francesco Pesce, Francesca Conserva, Barbara Infante, Giuseppe Castellano, Fabio Sallustio, Marco Fiorentino, Gianluigi Zaza, Anna Gallone, Michele Battaglia, Pasquale Ditonno, Giovanni Stallone, Loreto Gesualdo, Giuseppe Grandaliano
Summary: This study evaluated the recipients' characteristics in the development of delayed graft function (DGF) and found that the recipients' clinical/immunological features are associated with DGF independently of the donors' features.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Toxicology
Romain Pelletier, Brendan Le Dare, Diane Le Bouedec, Alexis Bourdais, Pierre-Jean Ferron, Isabelle Morel, Francois-Hugues Poree, Thomas Gicquel
Summary: This article reports a case of Eutylone intoxication and identifies Eutylone metabolites through nuclear magnetic resonance and mass spectrometry analysis. The concentration of Eutylone in blood samples was measured, and the findings contribute to the understanding of drug consumption markers and the development of mass spectrometry databases.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Nicky van der Heijde, Frederique L. Vissers, Alberto Manzoni, Giuseppe Zimmitti, Joaquim Balsells, Frederik Berrevoet, Bergthor Bjornsson, Peter van den Boezem, Ugo Boggi, Svein O. Bratlie, Fernando Burdio, Andrea Coratti, Mathieu D'Hondt, Carlos D. Del Pozo, Safi Dokmak, Regis Fara, Mehmet F. Can, Sebastiaan Festen, Antonello Forgione, Claus Fristrup, Sebastien Gaujoux, Bas Groot Koerkamp, Thilo Hackert, Igor E. Khatkov, Tobias Keck, Hanna Seppanen, Daan Lips, Misha Luyer, Gabriella Pittau, Manuel Maglione, I. Quintus Molenaar, Patrick Pessaux, Geert Roeyen, Olivier St-Marc, Santiago S. Cabus, Hjalmar van Santvoort, George van der Schelling, Mario Serradilla-Martin, Francois-regis Souche, Miguel A. Suarez Munoz, Marco Marino, Marc G. Besselink, Mohammed Abu Hilal
Summary: The E-MIPS registry collects data on laparoscopic and robotic minimally invasive pancreatic surgery (MIPS) across Europe. This study analyzed the first year of the registry and found that MIDP was performed in about half of the patients, mainly using laparoscopy, while MIPD was performed in about a quarter of the patients, more often using the robotic approach. There were only a minority of centers that met the Miami guideline volume criteria for MIPD.
Article
Endocrinology & Metabolism
Sophie Cassidy, Michael Trenell, Renae J. J. Stefanetti, Sarah J. J. Charman, Alison C. Barnes, Naomi Brosnahan, Louise McCombie, George Thom, Carl Peters, Sviatlana Zhyzhneuskaya, Wilma S. S. Leslie, Christopher Catt, Michael Catt, Alex McConnachie, Naveed Sattar, Falko F. F. Sniehotta, Michael E. J. Lean, Roy Taylor
Summary: In this study, randomization to weight loss plus maintenance intervention did not increase physical activity, although sleep parameters improved. Those who maintained >10% weight loss at 12 and 24 months had higher physical activity and reduced night-time waking.
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Review
Biochemistry & Molecular Biology
Katharina Lackner, Susanne Ebner, Katrin Watschinger, Manuel Maglione
Summary: Long-term results following solid organ transplantation do not match the short-term results achieved in recent decades, indicating the need for novel targets to address this issue. Macrophages play a crucial role in allograft rejection by promoting the adaptive immune response, but targeting them without considering subtypes may not be effective. This review explores the origins, plasticity, and important markers of macrophages, their role in acute allograft rejection, and the impact of immunosuppressants on macrophages. Recent findings suggest that tetrahydrobiopterin may have an immunosuppressive role, particularly in macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Julia Hofmann, Andras T. Meszaros, Madita L. Buch, Florian Nardin, Verena Hackl, Carola J. Strolz, Bettina Zelger, Margot Fodor, Benno Cardini, Rupert Oberhuber, Thomas Resch, Annemarie Weissenbacher, Jakob Troppmair, Stefan Schneeberger, Theresa Hautz
Summary: The majority of liver transplantation organs come from brain-dead donors, but there is an increasing consideration for donation after circulatory death (DCD) organs to overcome the shortage. Normothermic machine perfusion (NMP) can restore metabolic activity and assess organ quality and function. In comparing DCD and brain-dead donors (DBD) livers during NMP, DCD livers initially showed greater impairment of mitochondrial function, but eventually recovered and performed similarly to DBD livers. Cytokine analysis showed elevated levels in DCD livers towards the end of NMP. This study suggests the potential for using more DCD organs for transplantation, but donor organ quality criteria should be developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Matthew Jamieson, Heather McClelland, Nicola Goudie, Jean McFarlane, Breda Cullen, Marilyn Lennon, Stephen Brewster, Bethany Stanley, Alex McConnachie, Jonathan Evans
Summary: Mobile phone reminding apps are useful for people with acquired brain injury to compensate for memory impairments. This pilot feasibility trial aimed to establish the feasibility of a randomized controlled trial comparing reminder apps in an ABI community treatment setting. The results showed that most participants could learn to use the apps and a larger trial would require 72 participants.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Public, Environmental & Occupational Health
K. Walker-Bone, G. J. Macfarlane, K. Burton, A. M. McConnachie, R. Zhang, G. T. Jones
Summary: Arm pain is a common problem in the workplace. Advicing workers to keep using their arms as much as possible leads to less disability at 6 months, especially for those who lift heavy weights or believe work caused their symptoms. Early physiotherapy, however, made no difference to disability outcomes. Similar results were seen amongst workers diagnosed with lateral epicondylitis.
OCCUPATIONAL MEDICINE-OXFORD
(2023)
Article
Medicine, General & Internal
Veena Surendrakumar, Emma Aitken, Patrick Mark, Reza Motallebzadeh, James Hunter, Aimen Amer, Dominic Summers, Kirsten Rennie, Leila Rooshenas, Madalina Garbi, Karl Sylvester, Cara Hudson, Jennifer Banks, Anna Sidders, Andrew Norton, Matthew Slater, Matthew Bartlett, Simon Knight, Gavin Pettigrew
Summary: Cardiovascular events are a leading cause of death after successful kidney transplantation. This study aims to assess whether recipients with a well-functioning kidney transplant should undergo elective arteriovenous fistula (AVF) ligation, as AVFs may contribute to adverse cardiac remodeling. The study will evaluate patients' physical functioning and quality of life, and the results will be disseminated through academic conferences and peer-reviewed publications.
Article
Medicine, General & Internal
Ruben Bellotti, Benno Cardini, Carola J. Strolz, Stefan Staettner, Rupert Oberhuber, Eva Braunwarth, Thomas Resch, Stefan Scheidl, Christian Margreiter, Stefan Schneeberger, Dietmar Ofner, Manuel Maglione
Summary: This study compared three different reconstruction techniques for pancreaticoduodenectomy, and found that they did not significantly affect the rates of postoperative complications. However, pancreatogastrostomy had a higher incidence of post-pancreatectomy hemorrhage, indicating the need for meticulous hemostasis during the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jesse Dawson, Michele Robertson, David Alexander Dickie, Phillip Bath, Kirsten Forbes, Terence Quinn, Niall M. Broom, Krishna Dani, Alex Doney, Graeme Houston, Kennedy R. Lees, Keith W. Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Alexander Dyker, Paul Guyler, Ahamad Hassan, Mark T. Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Alex McConnachie
Summary: This study investigated whether allopurinol could reduce the progression of white matter hyperintensity (WMH) and blood pressure after an ischaemic stroke or transient ischaemic attack (TIA). The results showed that allopurinol had no significant effect on the progression of WMH and blood pressure.
Article
Cardiac & Cardiovascular Systems
Kenneth Mangion, Andrew J. Morrow, Robert Sykes, Anna Kamdar, Catherine Bagot, George Bruce, Paul Connelly, Christian Delles, Vivienne B. Gibson, Lynsey Gillespie, Pauline Hall Barriento, Vera Lennie, Giles Roditi, Naveed Sattar, David Stobo, Sarah Allwood-Spiers, Alex McConnachie, Colin Berry
Summary: A study found sex differences in myocardial inflammation in female post-COVID-19 patients, who also reported worse outcomes at index admission and 28-60 days follow-up, although they had lower rates of cardiovascular hospitalization.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Surgery
Felix J. Krendl, Margot Fodor, Franka Messner, Agnes Balog, Anja Vales, Benno Cardini, Thomas Resch, Manuel Maglione, Christian Margreiter, Marina Riedmann, Hanno Ulmer, Dietmar Oefner, Rupert Oberhuber, Stefan Schneeberger, Annemarie Weissenbacher
Summary: A positive crossmatch is usually not recommended for solid abdominal organ transplantation, except for liver transplantation. However, conflicting reports exist on the effects of a positive crossmatch on post-transplant outcomes. This study aimed to assess the influence of a positive crossmatch on relevant outcome parameters in liver transplantation patients. The results showed that a positive crossmatch did not affect patient and graft survival, rejection episodes, or the incidence of biliary and arterial complications. An association was found between a strong positive crossmatch and infection with PCR+ CMV.
TRANSPLANT INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Katharina Esswein, Marco Volpi, Marijana Ninkovic, Veronika Kroepfl, Elisabeth Gasser, Andreas Lorenz, Lea Stecher, Reinhold Kafka-Ritsch, Stefan Schneeberger, Dietmar Oefner, Alexander Perathoner
Summary: This study aimed to analyze the adherence to intensive follow-up and the risk of recurrence in patients with colon cancer in UICC stages I and II. The results showed that the risk of recurrence was low in early tumor stages, suggesting that a less intensive follow-up protocol is reasonable for these patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Urology & Nephrology
Laiis de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, Drielly C. M. de Vargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, Ludmila F. M. F. Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
Summary: Cinnamon, a widely used spice and traditional herbal medicine, may have beneficial effects on cardiovascular disease, obesity, and diabetes. However, its effectiveness for chronic kidney disease (CKD) remains uncertain. Bioactive compounds in cinnamon can mitigate common complications in CKD patients, such as oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia. This narrative review explores the mechanisms by which cinnamon may alleviate CKD complications and its potential role as an additional nutritional strategy for this patient group.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Surgery
Florian Primavesi, Manuel Maglione, Federica Cipriani, Timm Denecke, Christian E. Oberkofler, Patrick Starlinger, Bobby V. M. Dasari, Jan Heil, Olivia Sgarbura, Kjetil Soreide, Rafael Diaz-Nieto, Constantino Fondevila, Adam E. Frampton, Dominik Geisel, Benjamin Henninger, Amelia J. Hessheimer, Mickael Lesurtel, Damian Mole, Robert Ollinger, Pim Olthof, Thomas Reiberger, Andreas A. Schnitzbauer, Christoph Schwarz, Ernesto Sparrelid, Martin Stockmann, Stephanie Truant, Luca Aldrighetti, Eva Braunwarth, Mathieu D'Hondt, Michelle L. DeOliveira, Joris Erdmann, David Fuks, Thomas Gruenberger, Klaus Kaczirek, Hassan Malik, Dietmar Oefner, Nuh N. Rahbari, Georg Goebel, Ajith K. Siriwardena, Stefan Staettner
Summary: Posthepatectomy liver failure is a significant contributor to morbidity and mortality after liver resections. A standardized assessment of preoperative liver function is crucial in identifying patients at risk. These European consensus guidelines provide guidance for clinicians in planning safe liver surgery.
BRITISH JOURNAL OF SURGERY
(2023)