Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses

Dengue virus NS2 and NS4: Minor proteins, mammoth roles

(2018) Sindhoora Bhargavi Gopala Reddy et al.   BIOCHEMICAL PHARMACOLOGY

Evolution of tools and methods for monitoring autophagic flux in mammalian cells

(2018) Kevin C. Yang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Host target-based approaches against arboviral diseases

(2018) Rebeca Froes Rocha et al.   BIOLOGICAL CHEMISTRY

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

(2018) Jingshu Zhang et al.   Cell Host & Microbe

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

(2018) Takahide Matsui et al.   JOURNAL OF CELL BIOLOGY

Alphavirus Nucleocapsid Packaging and Assembly

(2018) Adriano Mendes et al.   Viruses-Basel

Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells

(2018) Haoran Peng et al.   Viruses-Basel

The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

(2018) Kai Zhi Wong et al.   Viruses-Basel

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

(2018) Ying-Ray Lee et al.   Scientific Reports

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New insights into autophagosome–lysosome fusion

(2017) Shuhei Nakamura et al.   JOURNAL OF CELL SCIENCE

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice

(2017) Bin Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagosome Maturation and Fusion

(2017) Fulvio Reggiori et al.   JOURNAL OF MOLECULAR BIOLOGY

Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy

(2017) Tristan X. Jordan et al.   JOURNAL OF VIROLOGY

The flavivirus capsid protein: Structure, function and perspectives towards drug design

(2017) Edson R.A. Oliveira et al.   VIRUS RESEARCH

Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins

(2017) Shun Chen et al.   Viruses-Basel

Philippines halts dengue immunisation campaign owing to safety risk

(2017) Owen Dyer   BMJ-British Medical Journal

Ultrastructural Characterization of Zika Virus Replication Factories

(2017) Mirko Cortese et al.   Cell Reports

Philippines halts dengue immunisation campaign owing to safety risk

(2017) Owen Dyer   BMJ-British Medical Journal

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

ATG proteins: Are we always looking at autophagy?

(2016) Mario Mauthe et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

(2016) Hengli Tang et al.   Cell Stem Cell

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

(2016) Qiming Liang et al.   Cell Stem Cell

Structure and function of the ULK1 complex in autophagy

(2016) Mary G Lin et al.   CURRENT OPINION IN CELL BIOLOGY

Global distribution and environmental suitability for chikungunya virus, 1952 to 2015

(2016) Elaine O Nsoesie et al.   Eurosurveillance

New developments in flavivirus drug discovery

(2016) W. Mei Kok   Expert Opinion on Drug Discovery

Epidemiology of Chikungunya in the Americas

(2016) Sergio Yactayo et al.   JOURNAL OF INFECTIOUS DISEASES

Dynamics of Chikungunya Virus Cell Entry Unraveled by Single-Virus Tracking in Living Cells

(2016) Tabitha E. Hoornweg et al.   JOURNAL OF VIROLOGY

The global burden of dengue: an analysis from the Global Burden of Disease Study 2013

(2016) Jeffrey D Stanaway et al.   LANCET INFECTIOUS DISEASES

Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection

(2016) Sarawut Khongwichit et al.   MICROBIAL PATHOGENESIS

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Myosins, Actin and Autophagy

(2016) Antonina J. Kruppa et al.   TRAFFIC

Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation

(2016) E Datan et al.   Cell Death & Disease

Dengue Virus Nonstructural Protein 1 Induces Vascular Leakage through Macrophage Migration Inhibitory Factor and Autophagy

(2016) Hong-Ru Chen et al.   PLoS Neglected Tropical Diseases

Properties and Functions of the Dengue Virus Capsid Protein

(2016) Laura A. Byk et al.   Annual Review of Virology

Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy

(2016) Xinwei Huang et al.   Scientific Reports

Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization

(2016) Yan-Wei Wu et al.   Scientific Reports

Reticulophagy and nucleophagy: New findings and unsolved issues

(2015) Hitoshi Nakatogawa et al.   Autophagy

Reconciling West Nile virus with the autophagic pathway

(2015) Miguel A Martín-Acebes et al.   Autophagy

Autophagy Receptor NDP52 Regulates Pathogen-Containing Autophagosome Maturation

(2015) Pauline Verlhac et al.   Cell Host & Microbe

WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome

(2015) T. Proikas-Cezanne et al.   JOURNAL OF CELL SCIENCE

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Alphavirus RNA synthesis and non-structural protein functions

(2015) Jonathan C. Rupp et al.   JOURNAL OF GENERAL VIROLOGY

Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62

(2015) Philippe Metz et al.   JOURNAL OF VIROLOGY

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

Early Events in Chikungunya Virus Infection—From Virus CellBinding to Membrane Fusion

(2015) Mareike van Duijl-Richter et al.   Viruses-Basel

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

(2015) Z Liu et al.   Cell Death & Disease

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

Amino acid substitutions in the non-structural proteins 4A or 4B modulate the induction of autophagy in West Nile virus infected cells independently of the activation of the unfolded protein response

(2015) Ana-Belén Blázquez et al.   Frontiers in Microbiology

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus

(2014) Carlo Amorin Daep et al.   JOURNAL OF NEUROVIROLOGY

Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial

(2014) Maria Rosario Capeding et al.   LANCET

Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection

(2014) Junqi Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Autophagy Facilitates Antibody-Enhanced Dengue Virus Infection in Human Pre-Basophil/Mast Cells

(2014) Yi-Ting Fang et al.   PLoS One

Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection

(2014) Shintaro Kobayashi et al.   VIRUS RESEARCH

Bunyavirus-Vector Interactions

(2014) Kate Horne et al.   Viruses-Basel

Chikungunya fever: Epidemiology, clinical syndrome, pathogenesis and therapy

(2013) Simon-Djamel Thiberville et al.   ANTIVIRAL RESEARCH

Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site

(2013) Ikuko Koyama-Honda et al.   Autophagy

Autophagy

(2013) Amber N. Hale et al.   Autophagy

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Species-specific impact of the autophagy machinery on Chikungunya virus infection

(2013) Delphine Judith et al.   EMBO REPORTS

Non-autophagic roles of autophagy-related proteins

(2013) Suresh Subramani et al.   EMBO REPORTS

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6

(2013) Siyu Wu et al.   JOURNAL OF INFECTION

Functional Characterization of the Alphavirus TF Protein

(2013) J. E. Snyder et al.   JOURNAL OF VIROLOGY

Nutrient regulation of the mTOR Complex 1 signaling pathway

(2013) Sang Gyun Kim et al.   MOLECULES AND CELLS

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of Cytopathogenicity in Human Glioblastoma Cells by Chikungunya Virus

(2013) Rachy Abraham et al.   PLoS One

Characterization of Synthetic Chikungunya Viruses Based on the Consensus Sequence of Recent E1-226V Isolates

(2013) Florine E. M. Scholte et al.   PLoS One

Hidden Behind Autophagy: The Unconventional Roles of ATG Proteins

(2013) Jovanka Bestebroer et al.   TRAFFIC

Replication Cycle and Molecular Biology of the West Nile Virus

(2013) Margo Brinton   Viruses-Basel

Autophagy as an Innate Immune Modulator

(2013) Ji Eun Oh et al.   Immune Network

The History of Dengue Outbreaks in the Americas

(2012) Olivia Brathwaite Dick et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

(2012) Shane Deegan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chikungunya virus–induced autophagy delays caspase-dependent cell death

(2012) Pierre-Emmanuel Joubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatitis C Virus-Induced Autophagy Is Independent of the Unfolded Protein Response

(2012) B.-P. Mohl et al.   JOURNAL OF VIROLOGY

Inhibition of Cellular Autophagy Deranges Dengue Virion Maturation

(2012) Roberto Mateo et al.   JOURNAL OF VIROLOGY

The Alphavirus E3 Glycoprotein Functions in a Clade-Specific Manner

(2012) A. J. Snyder et al.   JOURNAL OF VIROLOGY

Accumulation of Autophagosomes in Semliki Forest Virus-Infected Cells Is Dependent on Expression of the Viral Glycoproteins

(2012) K. E. Eng et al.   JOURNAL OF VIROLOGY

Differential Requirements in Endocytic Trafficking for Penetration of Dengue Virus

(2012) Eliana G. Acosta et al.   PLoS One

Flaviviruses and flavivirus vaccines

(2012) Franz X. Heinz et al.   VACCINE

West Nile virus growth is independent of autophagy activation

(2012) Erica Beatman et al.   VIROLOGY

Regulation of the Autophagic Bcl-2/Beclin 1 Interaction

(2012) Jean-Paul Decuypere et al.   Cells

Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication

(2011) Jeffrey E. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induced autophagy reduces virus output in dengue infected monocytic cells

(2011) Mingkwan Panyasrivanit et al.   VIROLOGY

Chikungunya triggers an autophagic process which promotes viral replication

(2011) Pascale Krejbich-Trotot et al.   Virology Journal

Functional RNA Elements in the Dengue Virus Genome

(2011) Leopoldo G. Gebhard et al.   Viruses-Basel

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

Dengue virus life cycle: viral and host factors modulating infectivity

(2010) Izabela A. Rodenhuis-Zybert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New insights into the function of Atg9

(2010) Jemma L. Webber et al.   FEBS LETTERS

Mechanisms of Immune Evasion Induced by a Complex of Dengue Virus and Preexisting Enhancing Antibodies

(2010) Sukathida Ubol et al.   JOURNAL OF INFECTIOUS DISEASES

Phosphatidylinositol 3-Kinase-, Actin-, and Microtubule-Dependent Transport of Semliki Forest Virus Replication Complexes from the Plasma Membrane to Modified Lysosomes

(2010) P. Spuul et al.   JOURNAL OF VIROLOGY

West Nile Virus Differentially Modulates the Unfolded Protein Response To Facilitate Replication and Immune Evasion

(2010) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism

(2010) Akiko Kuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Linking dengue virus entry and translation/replication through amphisomes

(2009) Mingkwan Panyasrivanit et al.   Autophagy

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Pathogenesis of Flavivirus Infections: Using and Abusing the Host Cell

(2009) Maria-Dolores Fernandez-Garcia et al.   Cell Host & Microbe

Alternative infectious entry pathways for dengue virus serotypes into mammalian cells

(2009) Eliana G. Acosta et al.   CELLULAR MICROBIOLOGY

GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagy

(2009) Vladimir M. Korkhov   JOURNAL OF CELLULAR BIOCHEMISTRY

Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes

(2009) M. Panyasrivanit et al.   JOURNAL OF GENERAL VIROLOGY

A role for autophagolysosomes in dengue virus 3 production in HepG2 cells

(2009) A. Khakpoor et al.   JOURNAL OF GENERAL VIROLOGY

The Medicinal Chemistry of Dengue Fever

(2009) Andrew J. Stevens et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replication cycle of chikungunya: A re-emerging arbovirus

(2009) Maxime Solignat et al.   VIROLOGY

Closing the door on flaviviruses: Entry as a target for antiviral drug design

(2008) Rushika Perera et al.   ANTIVIRAL RESEARCH

Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target

(2008) J LESCAR et al.   ANTIVIRAL RESEARCH

Functional importance of dengue virus maturation: infectious properties of immature virions

(2008) I. A. Zybert et al.   JOURNAL OF GENERAL VIROLOGY

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

(2008) Hongping Dong et al.   VIROLOGY

Autophagic machinery activated by dengue virus enhances virus replication

(2008) Ying-Ray Lee et al.   VIROLOGY

Genome cyclization as strategy for flavivirus RNA replication

(2008) Sergio M. Villordo et al.   VIRUS RESEARCH

Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells

(2008) Hilde M. van der Schaar et al.   PLoS Pathogens