Replication Cycle and Molecular Biology of the West Nile Virus

The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3′ UTR

(2013) Chen Li et al.   ANTIVIRAL RESEARCH

Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization

(2013) Holger Hannemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex

(2013) Young Mee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane undulation induced by NS4A of Dengue virus: a molecular dynamics simulation study

(2013) Meng-Han Lin et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein

(2013) C. S. E. Tan et al.   JOURNAL OF GENERAL VIROLOGY

Integrins modulate the infection efficiency of West Nile virus into cells

(2013) K. Schmidt et al.   JOURNAL OF GENERAL VIROLOGY

Increased Early RNA Replication by Chimeric West Nile Virus W956IC Leads to IPS-1-Mediated Activation of NF- B and Insufficient Virus-Mediated Counteraction of the Resulting Canonical Type I Interferon Signaling

(2013) S. V. Scherbik et al.   JOURNAL OF VIROLOGY

Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

(2013) A. Kumar et al.   JOURNAL OF VIROLOGY

Novel cis-Acting Element within the Capsid-Coding Region Enhances Flavivirus Viral-RNA Replication by Regulating Genome Cyclization

(2013) Z.-Y. Liu et al.   JOURNAL OF VIROLOGY

Differential RNA Sequence Requirement for Dengue Virus Replication in Mosquito and Mammalian Cells

(2013) S. M. Villordo et al.   JOURNAL OF VIROLOGY

Identification of cis-Acting Nucleotides and a Structural Feature in West Nile Virus 3'-Terminus RNA That Facilitate Viral Minus Strand RNA Synthesis

(2013) W. G. Davis et al.   JOURNAL OF VIROLOGY

NS1' Colocalizes with NS1 and Can Substitute for NS1 in West Nile Virus Replication

(2013) L. B. Young et al.   JOURNAL OF VIROLOGY

Membrane Topology and Function of Dengue Virus NS2A Protein

(2013) X. Xie et al.   JOURNAL OF VIROLOGY

An N-Terminal Amphipathic Helix in Dengue Virus Nonstructural Protein 4A Mediates Oligomerization and Is Essential for Replication

(2013) O. Stern et al.   JOURNAL OF VIROLOGY

Three-Dimensional Architecture of Tick-Borne Encephalitis Virus Replication Sites and Trafficking of the Replicated RNA

(2013) L. Miorin et al.   JOURNAL OF VIROLOGY

Structural complexity of Dengue virus untranslated regions: cis -acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome

(2013) Joanna Sztuba-Solinska et al.   NUCLEIC ACIDS RESEARCH

Steady-State NTPase Activity of Dengue Virus NS3: Number of Catalytic Sites, Nucleotide Specificity and Activation by ssRNA

(2013) J. Jeremías Incicco et al.   PLoS One

Do RNA viruses require genome cyclisation for replication?

(2013) William B. Lott et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein–protein interactions among West Nile non-structural proteins and transmembrane complex formation in mammalian cells

(2013) Li Yu et al.   VIROLOGY

The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication

(2013) Ana TS Morais et al.   Virology Journal

Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle

(2013) Tanvi Agrawal et al.   Scientific Reports

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

(2013) Stephanie Jemielity et al.   PLoS Pathogens

West Nile Virus (WNV) protease and membrane interactions revealed by NMR spectroscopy

(2012) Shovanlal Gayen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

West Nile virus NS2A protein facilitates virus-induced apoptosis independently of interferon response

(2012) E. B. Melian et al.   JOURNAL OF GENERAL VIROLOGY

A single nucleotide mutation in NS2A of Japanese encephalitis-live vaccine virus (SA14-14-2) ablates NS1' formation and contributes to attenuation

(2012) Q. Ye et al.   JOURNAL OF GENERAL VIROLOGY

Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus

(2012) S. Youn et al.   JOURNAL OF VIROLOGY

West Nile Virus Infections Suppress Early Viral RNA Synthesis and Avoid Inducing the Cell Stress Granule Response

(2012) S. C. Courtney et al.   JOURNAL OF VIROLOGY

Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation

(2012) H. Katoh et al.   JOURNAL OF VIROLOGY

ATF6 Signaling Is Required for Efficient West Nile Virus Replication by Promoting Cell Survival and Inhibition of Innate Immune Responses

(2012) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

Blocking Double-Stranded RNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A

(2012) Y.-C. Tu et al.   JOURNAL OF VIROLOGY

The West Nile Virus Capsid Protein Blocks Apoptosis through a Phosphatidylinositol 3-Kinase-Dependent Mechanism

(2012) M. D. Urbanowski et al.   JOURNAL OF VIROLOGY

Japanese encephalitis virus NS1′ protein depends on pseudoknot secondary structure and is cleaved by caspase during virus infection and cell apoptosis

(2012) Jin Sun et al.   MICROBES AND INFECTION

Novel ATP-Independent RNA Annealing Activity of the Dengue Virus NS3 Helicase

(2012) Leopoldo G. Gebhard et al.   PLoS One

West Nile Virus Infection Causes Endocytosis of a Specific Subset of Tight Junction Membrane Proteins

(2012) Zaikun Xu et al.   PLoS One

West Nile Virus (WNV) Replication Is Independent of Autophagy in Mammalian Cells

(2012) Rianna Vandergaast et al.   PLoS One

The helicase activity of DDX56 is required for its role in assembly of infectious West Nile virus particles

(2012) Zaikun Xu et al.   VIROLOGY

Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells

(2012) Joanna A. Pulit-Penaloza et al.   VIROLOGY

Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

(2012) Greta A. Van Slyke et al.   VIROLOGY

A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells and regulates viral replication in Aedes aegypti mosquitoes

(2012) Anna Maria Groat-Carmona et al.   VIROLOGY

West Nile virus growth is independent of autophagy activation

(2012) Erica Beatman et al.   VIROLOGY

Mutational analysis of the West Nile virus NS4B protein

(2012) Jason A. Wicker et al.   VIROLOGY

West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals

(2012) Giovanni Faggioni et al.   Virology Journal

Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication

(2012) Wessam Melik et al.   VIRUS RESEARCH

Core protein-mediated 5′–3′ annealing of the West Nile virus genomic RNA in vitro

(2012) Roland Ivanyi-Nagy et al.   VIRUS RESEARCH

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

(2012) Caroline Le Sommer et al.   PLoS Neglected Tropical Diseases

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen

(2011) Marc Le Breton et al.   BMC MICROBIOLOGY

La Protein Can Simultaneously Bind to Both 3′- and 5′-Noncoding Regions of Japanese Encephalitis Virus Genome

(2011) Surender Vashist et al.   DNA AND CELL BIOLOGY

RNA binding property and RNA chaperone activity of dengue virus core protein and other viral RNA-interacting proteins

(2011) Wen-Li Pong et al.   FEBS LETTERS

Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication

(2011) Jeffrey E. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification ofCis-Acting Elements in the 3′-Untranslated Region of the Dengue Virus Type 2 RNA That Modulate Translation and Replication

(2011) Mark Manzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FUSE Binding Protein 1 Interacts with Untranslated Regions of Japanese Encephalitis Virus RNA and Negatively Regulates Viral Replication

(2011) H.-L. Chien et al.   JOURNAL OF VIROLOGY

Inhibition of Dengue Virus by Targeting Viral NS4B Protein

(2011) X. Xie et al.   JOURNAL OF VIROLOGY

The Capsid-Binding Nucleolar Helicase DDX56 Is Important for Infectivity of West Nile Virus

(2011) Z. Xu et al.   JOURNAL OF VIROLOGY

The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis

(2011) N. G. Iglesias et al.   JOURNAL OF VIROLOGY

NF90 Binds the Dengue Virus RNA 3′ Terminus and Is a Positive Regulator of Dengue Virus Replication

(2011) Raúl C. Gomila et al.   PLoS One

West Nile Virus Replication Requires Fatty Acid Synthesis but Is Independent on Phosphatidylinositol-4-Phosphate Lipids

(2011) Miguel A. Martín-Acebes et al.   PLoS One

Analysis of RNA Binding by the Dengue Virus NS5 RNA Capping Enzyme

(2011) Brittney R. Henderson et al.   PLoS One

Dynamic RNA structures in the dengue virus genome

(2011) Nestor G. Iglesias et al.   RNA Biology

Multiple amino acid changes at the first glycosylation motif in NS1 protein of West Nile virus are necessary for complete attenuation for mouse neuroinvasiveness

(2011) Melissa C. Whiteman et al.   VACCINE

N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement

(2011) Pawit Somnuke et al.   VIROLOGY

West Nile virus (WNV) genome RNAs with up to three adjacent mutations that disrupt long distance 5′–3′ cyclization sequence basepairs are viable

(2011) Mausumi Basu et al.   VIROLOGY

West Nile virus infection does not induce PKR activation in rodent cells

(2011) H. Elbahesh et al.   VIROLOGY

Analyses of mutations selected by passaging a chimeric flavivirus identify mutations that alter infectivity and reveal an interaction between the structural proteins and the nonstructural glycoprotein NS1

(2011) Evandro R. Winkelmann et al.   VIROLOGY

Composition of the sequence downstream of the dengue virus 5′ cyclization sequence (dCS) affects viral RNA replication

(2011) Peter Friebe et al.   VIROLOGY

DnaJ homolog Hdj2 Facilitates Japanese Encephalitis Virus Replication

(2011) Robert Wang et al.   Virology Journal

Small noncoding RNA modulates japanese encephalitis virus replication and translation in trans

(2011) Yi-Hsin Fan et al.   Virology Journal

Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs

(2010) Boris Pastorino et al.   ANTIVIRAL RESEARCH

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes

(2010) Gong Cheng et al.   CELL

Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

(2010) Dahai Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1

(2010) Panisadee Avirutnan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

(2010) M. Laurent-Rolle et al.   JOURNAL OF VIROLOGY

The 5' and 3' Downstream AUG Region Elements Are Required for Mosquito-Borne Flavivirus RNA Replication

(2010) P. Friebe et al.   JOURNAL OF VIROLOGY

Virus-Induced Ca2+ Influx Extends Survival of West Nile Virus-Infected Cells

(2010) S. V. Scherbik et al.   JOURNAL OF VIROLOGY

RNA Structures Required for Production of Subgenomic Flavivirus RNA

(2010) A. Funk et al.   JOURNAL OF VIROLOGY

Interplay of RNA Elements in the Dengue Virus 5' and 3' Ends Required for Viral RNA Replication

(2010) P. Friebe et al.   JOURNAL OF VIROLOGY

The Endoplasmic Reticulum Provides the Membrane Platform for Biogenesis of the Flavivirus Replication Complex

(2010) Leah K. Gillespie et al.   JOURNAL OF VIROLOGY

West Nile Virus Differentially Modulates the Unfolded Protein Response To Facilitate Replication and Immune Evasion

(2010) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

Appraising the Roles of CBLL1 and the Ubiquitin/Proteasome System for Flavivirus Entry and Replication

(2010) M.-D. Fernandez-Garcia et al.   JOURNAL OF VIROLOGY

Interaction between the yellow fever virus nonstructural protein NS3 and the host protein Alix contributes to the release of infectious particles

(2010) Lindsay N. Carpp et al.   MICROBES AND INFECTION

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

(2010) Li Jian Yap et al.   PLoS One

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A balance between circular and linear forms of the dengue virus genome is crucial for viral replication

(2010) S. M. Villordo et al.   RNA

Genetic analysis of West Nile virus containing a complete 3′CSI RNA deletion

(2010) Bo Zhang et al.   VIROLOGY

Nonstructural NS1 proteins of several mosquito-borne Flavivirus do not inhibit TLR3 signaling

(2010) Cécile Baronti et al.   VIROLOGY

Translational Regulation by the 3′ Untranslated Region of the Dengue Type 2 Virus Genome

(2009) Yan Wei et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Dengue virus-induced regulation of the host cell translational machinery

(2009) C.S.A. Villas-Bôas et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein

(2009) Chun-Chung Wang et al.   FEBS LETTERS

NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus

(2009) S. A. Shiryaev et al.   JOURNAL OF GENERAL VIROLOGY

Poly(A)-binding protein binds to the non-polyadenylated 3' untranslated region of dengue virus and modulates translation efficiency

(2009) C. Polacek et al.   JOURNAL OF GENERAL VIROLOGY

NS1' of Flaviviruses in the Japanese Encephalitis Virus Serogroup Is a Product of Ribosomal Frameshifting and Plays a Role in Viral Neuroinvasiveness

(2009) E. B. Melian et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

(2009) R. Assenberg et al.   JOURNAL OF VIROLOGY

West Nile Virus Capsid Degradation of Claudin Proteins Disrupts Epithelial Barrier Function

(2009) G. R. Medigeshi et al.   JOURNAL OF VIROLOGY

Discovery of insect and human dengue virus host factors

(2009) October M. Sessions et al.   NATURE

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

(2009) M. Issur et al.   RNA

Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus

(2009) Melissa C. Whiteman et al.   VACCINE

A conserved predicted pseudoknot in the NS2A-encoding sequence of West Nile and Japanese encephalitis flaviviruses suggests NS1' may derive from ribosomal frameshifting

(2009) Andrew E Firth et al.   Virology Journal

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

(2008) Dahai Luo et al.   EMBO JOURNAL

Structure of West Nile Virus NS3 Protease: Ligand Stabilization of the Catalytic Conformation

(2008) Gautier Robin et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic Interactions among the West Nile Virus Methyltransferase, the RNA-Dependent RNA Polymerase, and the 5' Stem-Loop of Genomic RNA

(2008) B. Zhang et al.   JOURNAL OF VIROLOGY

Structural and Functional Studies of the Promoter Element for Dengue Virus RNA Replication

(2008) M. F. Lodeiro et al.   JOURNAL OF VIROLOGY

Conformational Changes in the Solution Structure of the Dengue Virus 5' End in the Presence and Absence of the 3' Untranslated Region

(2008) C. Polacek et al.   JOURNAL OF VIROLOGY

West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of  v 3 Integrin

(2008) G. R. Medigeshi et al.   JOURNAL OF VIROLOGY

West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction

(2008) J. R. Wilson et al.   JOURNAL OF VIROLOGY

Mutation of Mapped TIA-1/TIAR Binding Sites in the 3' Terminal Stem-Loop of West Nile Virus Minus-Strand RNA in an Infectious Clone Negatively Affects Genomic RNA Amplification

(2008) M. M. Emara et al.   JOURNAL OF VIROLOGY

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE

Analysis of the effects of alterations in the tick-borne encephalitis virus 3′-noncoding region on translation and RNA replication using reporter replicons

(2008) Verena M. Hoenninger et al.   VIROLOGY

Functional analysis of dengue virus cyclization sequences located at the 5′ and 3′UTRs

(2008) Diego E. Alvarez et al.   VIROLOGY

The capsid-coding region hairpin element (cHP) is a critical determinant of dengue virus and West Nile virus RNA synthesis

(2008) Karen Clyde et al.   VIROLOGY

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

(2008) Hongping Dong et al.   VIROLOGY

West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions

(2008) Bo Zhang et al.   VIROLOGY

Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells

(2008) Hilde M. van der Schaar et al.   PLoS Pathogens