Article
Chemistry, Medicinal
Elena Moiseenko, Reka Erdei, Natalia E. Grammatikova, Elena P. Mirchink, Elena B. Isakova, Eleonora R. Pereverzeva, Gyula Batta, Andrey E. Shchekotikhin
Summary: This study aimed to evaluate the antimicrobial potential of new eremomycin amides and investigate their structure-activity relationships. The results indicated that the selected target showed significant advantages.
Article
Microbiology
Andy Hesketh, Giselda Bucca, Colin P. Smith, Hee-Jeon Hong
Summary: Dalbavancin, vancomycin, and chlorobiphenyl-vancomycin are glycopeptide antibiotics with similar structures and modes of action, but they induce different gene expression patterns and have diverse impacts on bacterial cell wall biosynthesis and other physiological processes.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Guojun Sun, Qian Zhang, Zuojun Dong, Dashun Dong, Hui Fang, Chaojun Wang, Yichen Dong, Jiezhou Wu, Xuanzhe Tan, Peiyao Zhu, Yuehua Wan
Summary: This paper reviewed research on antibiotic-resistant bacteria (ARB) from 2010 to 2020 using bibliometrics. The analysis provided insights into the countries, institutions, journals, authors, research areas, and research trends in the field. The findings revealed an increasing number of studies over the years, with the USA and China being the most active research countries and environmental sciences and ecology being the most popular research areas.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Patrick Muinde, John Maina, Kelvin Momanyi, Victor Yamo, John Mwaniki, John Kiiru
Summary: There is a growing problem of bacterial resistance to antibiotics globally, jeopardizing the effectiveness of essential antimicrobials in reducing disease mortality and morbidity. Bacteria in animals are believed to serve as reservoirs of resistance genes that can be transmitted to humans through the food chain. A study in Kenya examined the resistance patterns of bacteria in pork and poultry meat samples from leading retail outlets, and found high contamination rates and a significant proportion of multidrug-resistant isolates, including resistance to critically important antimicrobials for human and veterinary medicine. It is crucial to raise awareness on the proper use of antibiotics and implement preventive measures to reduce the burden of disease.
Article
Environmental Sciences
Shuai Zhang, Yu Zhang, Yue Wang, Xingxiang Liu, Muyu Li, Hao Fang, Ming Kong
Summary: Surface runoff is a main pathway for emerging pollutants, including antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes, to enter marine sediments. This study investigates the impact of emerging pollutants on the fate of antibiotic resistance genes in marine sediments from different seas in China. The results show that antibiotic exposure generally decreases the relative abundance of most antibiotic resistance genes, but there are exceptions with increased abundance observed in certain conditions. The findings suggest that dosing with emerging pollutants does not increase antibiotic resistance gene abundance in marine sediments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Infectious Diseases
Xiangyi Cui, Yuhong Lu, Changwu Yue
Summary: Bacterial resistance due to antibiotic overuse has become a serious global issue, necessitating stronger control measures and development of new drugs targeting resistant bacteria.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Andres Andreo-Vidal, Elisa Binda, Victor Fedorenko, Flavia Marinelli, Oleksandr Yushchuk
Summary: The global health security is challenged by the spread of antimicrobial resistance, affecting even glycopeptide antibiotics. Research has shown that GPA resistance determinants can be found not only in GPA producers, but also in non-producers, indicating a co-evolution of different vlgs.
Article
Chemistry, Medicinal
Florian Umstaetter, Julia Werner, Leah Zerlin, Eric Muehlberg, Christian Kleist, Karel D. Klika, Tobias Hertlein, Barbro Beijer, Cornelius Domhan, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Walter Mier, Philipp Uhl
Summary: As multidrug-resistant bacteria pose a serious threat, it is crucial to rethink antibiotic use and development. In this study, highly active polycationic peptide-vancomycin conjugates were synthesized to optimize pharmacokinetics while maintaining or even increasing antimicrobial activity. Linker modification of these conjugates showed promising results in modulating pharmacokinetic behavior and providing potent antimicrobial activity.
Article
Engineering, Environmental
Bongkotrat Suyamud, Jenyuk Lohwacharin, Yuyi Yang, Virender K. Sharma
Summary: This study investigated the presence of antibiotics, antibiotic resistant bacteria (ARB), and antibiotic resistance genes (ARGs) in aquaculture waters, as well as the removal effects of ferrate (Fe(VI), FeO42-). It found that water quality parameters significantly influenced the dissemination of tetracycline resistance genes in aquaculture waters, and the efficiency of antibiotics removal by Fe(VI) depended on the structural moieties of antibiotics. The results suggest that the constituents of farming water enhance the efficacy of antibiotics removal by Fe(VI), and an acidic pH environment can enhance Fe(VI) inactivation of ARB over circumneutral pH.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Maxwell J. Moore, Pengjin Qin, D. Jamin Keith, Zhi-Chen Wu, Sunna Jung, Shreyosree Chatterjee, Ceheng Tan, Shiwei Qu, Yu Cai, Robyn L. Stanfield, Dale L. Boger
Summary: This paper presents a new simplified and expanded divergent total synthesis method for pocket-modified vancomycin analogs, which provides a common late-stage intermediate [Psi[C(=S)NH]Tpg(4)]vancomycin. Highlights of this approach include an atroposelective synthesis of [Psi[C(=S)NH]Tpg(4)]-vancomycin aglycon, a one-pot enzymatic glycosylation for direct conversion to [Psi[C(=S)NH]Tpg(4)]vancomycin, and new methods for late-stage conversion of the embedded thioamide to amidine/aminomethylene pocket modifications. In addition, the potent antimicrobial activity of the new amidine-based maxamycins is demonstrated, showing equipotent activity against both vancomycin-sensitive and vancomycin-resistant Gram-positive organisms.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Environmental
Tomislav Ivankovic, Helena Turk, Jasna Hrenovic, Zdravko Schauperl, Marica Ivankovic, Antonia Ressler
Summary: A novel biomaterial utilizing silver ions within the hydroxyapatite lattice has been developed to address the issue of multi-drug resistance in Acinetobacter baumannii infections. The antibacterial activity of the biomaterial was examined against A. baumannii clinical isolates, showing strong efficacy. The concentration of silver ions in the biomaterial was found to impact the antibacterial effect.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Le Zhai, Ya Liu, Yue Jiang, Jian Xiao, Yi-Xue Wang, Yang Shi, Yi-Lin Zhang, Ke-Wu Yang
Summary: In this study, a novel vancomycin derivative V-b was constructed and shown to have significant antimicrobial effects against drug-resistant strains, enhancing the antibacterial activity of β-lactam antibiotics. Furthermore, V-b was able to enhance the antimicrobial activity of meropenem against clinical isolates and E. coli producing ImiS and CcrA.
Review
Environmental Sciences
Xia Yuan, Ziqing Lv, Zeyu Zhang, Yu Han, Zhiquan Liu, Hangjun Zhang
Summary: Antibiotics are commonly used in aquaculture to prevent and control diseases, but their overuse leads to the development of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). The presence and transfer mechanisms of antibiotics, ARB, and ARGs in water, sediment, and aquaculture organisms are summarized in this paper. The key mechanisms of antibiotic resistance in bacteria include changes in cell membrane permeability, antibiotic efflux enhancement, and structural changes in antibiotic target proteins.
Article
Pharmacology & Pharmacy
Jingru Shi, Chen Chen, Dejuan Wang, Ziwen Tong, Zhiqiang Wang, Yuan Liu
Summary: The study demonstrated that peptide WW307 displayed potent antibacterial activity against MDR bacteria, especially MRSA and Gram-negative pathogens carrying bla(NDM-5), mcr-1 or tet(X4). Additionally, WW307 showed great biofilm inhibition and eradication activity. Safety and stability experiments also indicated that WW307 had potential as a candidate for combating MDR pathogens.
Article
Microbiology
Lewis F. Neville, Itamar Shalit, Peter A. Warn, Marc H. Scheetz, Jiuzhi Sun, Madeline B. Chosy, Paul A. Wender, Lynette Cegelski, Jacob T. Rendell
Summary: Vancomycin-arginine (V-r) has the ability to extend the activity of glycopeptides to Gram-negative bacteria, with acute bactericidal effects on Escherichia coli and low resistance frequency. In vivo experiments showed V-r significantly reduced E. coli burden by >7 log(10), CFU/g. These findings support further development of V-r in combating E. coli, including resistant forms.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Paramita Sarkar, Sandip Samaddar, Veena Ammanathan, Venkateswarlu Yarlagadda, Chandradhish Ghosh, Manjulika Shukla, Grace Kaul, Ravi Manjithaya, Sidharth Chopra, Jayanta Haldar
ACS CHEMICAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Venkateswarlu Yarlagadda, Ricardo Medina, Gerard D. Wright
SCIENTIFIC REPORTS
(2020)
Article
Agriculture, Dairy & Animal Science
Partha Sarathi Swain, Somu Bala Nageswara Rao, Duraisamy Rajendran, Paramanandham Krishnamoorthy, Sukanta Mondal, Dintaran Pal, Sellapan Selvaraju
Summary: The trial aimed to evaluate the potential benefits of nano zinc (NZn) compared to inorganic zinc (Zn) on goat immunity and hormone profiles. NZn supplementation showed improvements in IGF-1 levels and humoral immunity, while both Zn and NZn supplementation enhanced cell-mediated immunity.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Review
Veterinary Sciences
Paramanandham Krishnamoorthy, Akshata Lokanath Goudar, Kuralayanapalya Puttahonnappa Suresh, Parimal Roy
Summary: This study calculated the prevalence of subclinical mastitis (SCM) and clinical mastitis (CM) in various countries, finding a higher prevalence of SCM compared to CM worldwide, with both having high rates in India. The research suggests the importance of addressing SCM and CM through improved dairy management practices to benefit dairy farmers globally.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Medicinal
Venkateswarlu Yarlagadda, Vishwas N. Rao, Manpreet Kaur, Allison K. Guitor, Gerard D. Wright
Summary: The increasing multidrug resistance in Neisseria gonorrheae is a growing public health crisis. Moenomycin, identified from a screen of microbial natural products, shows excellent activity against multidrug-resistant N. gonorrheae and has the potential to be a lead for antigonococcal therapeutic candidates.
ACS INFECTIOUS DISEASES
(2021)
Article
Microbiology
Paramanandham Krishnamoorthy, Kuralayanapalya P. Suresh, Kavitha S. Jayamma, Bibek R. Shome, Sharanagouda S. Patil, Raghavendra G. Amachawadi
Summary: This study estimated the prevalence of major mastitis pathogens in cattle and buffalo worldwide through meta-analysis. Staphylococcus aureus was identified as the main pathogen causing subclinical mastitis, while Escherichia coli and Streptococcus were associated with clinical and subclinical mastitis. The prevalence rates of these pathogens were found to be high in Latin America and Oceania, with molecular methods showing potential for future studies.
Article
Agriculture, Dairy & Animal Science
Sharanagouda S. Patil, Kuralayanapalya Puttahonnappa Suresh, Divakar Hemadri, Jagadish Hiremath, Rajangam Sridevi, Paramanadham Krishnamoorthy, Sandeep Bhatia, Parimal Roy
Summary: This study assessed the seroprevalence of classical swine fever in India, finding different seropositivity rates among pigs in different regions and age groups, and analyzed the environmental factors influencing the disease prevalence.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2021)
Article
Parasitology
Paramanandham Krishnamoorthy, Subramanium Sudhagar, Akshata Lokanath Goudar, Siju Susan Jacob, Kuralayanapalya Puttahonappa Suresh
Summary: This study conducted a molecular survey of cattle ticks and tick-borne pathogens in various agroclimatic zones in Karnataka and Kerala states, India. The study identified multiple tick genera and pathogens, with Rhipicephalus species being predominant. Phylogenetic analysis revealed sequence homology between isolates from India and neighbouring countries, providing crucial information for developing effective control measures.
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2021)
Review
Parasitology
Siju Susan Jacob, P. P. Sengupta, P. Krishnamoorthy, K. P. Suresh, S. S. Patil, A. G. S. Chandu, J. K. Chamuah, H. Lalrinkima, B. R. Shome
Summary: The present study aimed to estimate the prevalence of bovine babesiosis in India and found a wide prevalence of the disease. The evaluation of active infection and seroprevalence separately helps to understand the actual disease prevalence in the country.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
P. Krishnamoorthy, H. K. Lakshmi, S. J. Siju, K. P. Suresh, B. R. Shome
Summary: This study estimated the prevalence of gastrointestinal parasites in pigs from India using scientometrics. The prevalence of gastrointestinal parasites was found to be 54% in India, with a higher prevalence reported in 2010 compared to recent years. The study identified the highest prevalence in the South zone and the lowest in the West zone, as well as regional variations in parasite prevalence. The findings of this study can assist stakeholders and decision makers in implementing control and preventive measures for the management of gastrointestinal parasites in pigs.
INDIAN JOURNAL OF ANIMAL SCIENCES
(2022)
Article
Parasitology
Paramanandham Krishnamoorthy, Hosagavi Keshava Lakshmi, Siju Susan Jacob, Kuralayanapalya Puttahonappa Suresh, Bibek Ranjan Shome
Summary: In this study, the prevalence of gastrointestinal parasites (GIP) in sheep and goats in India was estimated using scientometrics. A total of 86 studies on GIP prevalence from 1998 to 2021 were collected and analyzed. The overall prevalence of GIP in India was found to be 65% in sheep, 74% in goats, and 68% in sheep and goats combined. Factors such as time period, geographic zone, and climatic region were found to influence the prevalence rates. This information is valuable for policymakers and stakeholders in making decisions and improving resource allocation.
ACTA PARASITOLOGICA
(2023)
Article
Multidisciplinary Sciences
Deepa Bhagat, Aamina Manzoor, Akanksha Mahajan, Umesh Kumar Sanjeev, B. C. Sharma, Paramanandham Krishnamoorthy, Duleep Kumar Samuel, S. N. Sushil
Summary: Chitosan nanopowder, with its biocompatible and biochemical properties, can be used as a nanocarrier in agriculture to enhance plant defenses against insects and pathogens. This study investigates the potential toxicity of chitosan nanopowder on the egg parasitoid Trichogramma Japonicum Ashmead and finds that it promotes parasitization. The findings are supported by various experiments and microscopy images.
Article
Veterinary Sciences
Kuralayanapalya Puttahonnappa Suresh, Sharanagouda Patil, Uma Bharathi Indrabalan, Rajangam Sridevi, Paramanadham Krishnamoorthy, Shinduja Rajamani, Parimal Roy
EXPLORATORY ANIMAL AND MEDICAL RESEARCH
(2020)
Article
Chemistry, Medicinal
Venkateswarlu Yarlagadda, Ricardo Medina, Timothy A. Johnson, Kalinka P. Koteva, Georgina Cox, Maulik N. Thaker, Gerard D. Wright
ACS INFECTIOUS DISEASES
(2020)
Article
Agriculture, Dairy & Animal Science
P. Krishnamoorthy, K. P. Suresh, R. Dheeraj, Parimal Roy
INDIAN JOURNAL OF ANIMAL SCIENCES
(2020)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
