Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis

Single-Molecule Fluorescence Imaging of Interfacial DNA Hybridization Kinetics at Selective Capture Surfaces

(2016) Eric M. Peterson et al.   ANALYTICAL CHEMISTRY

Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping

(2016) Kevin J. Freedman et al.   Nature Communications

Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples

(2015) Danlu Wu et al.   ANALYST

Ultrasensitive Detection of Ricin Toxin in Multiple Sample Matrixes Using Single-Domain Antibodies

(2015) Shonda T. Gaylord et al.   ANALYTICAL CHEMISTRY

A Universal Strategy for Aptamer-Based Nanopore Sensing through Host-Guest Interactions inside α-Hemolysin

(2015) Ting Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single occupancy spectroelectrochemistry of freely diffusing flavin mononucleotide in zero-dimensional nanophotonic structures

(2015) Lawrence P. Zaino et al.   FARADAY DISCUSSIONS

Single-Molecule Arrays for Ultrasensitive Detection of Host Immune Response to Dengue Virus Infection

(2015) Shonda T. Gaylord et al.   JOURNAL OF CLINICAL MICROBIOLOGY

High-throughput optical sensing of nucleic acids in a nanopore array

(2015) Shuo Huang et al.   Nature Nanotechnology

Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection

(2015) Yuanhui Zheng et al.   Nature Communications

Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring

(2015) Stephanie M. Schubert et al.   Scientific Reports

Single occupancy spectroelectrochemistry of freely diffusing flavin mononucleotide in zero-dimensional nanophotonic structures

(2015) Lawrence P. Zaino et al.   FARADAY DISCUSSIONS

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

Digital biology and chemistry

(2014) Daan Witters et al.   LAB ON A CHIP

Circle-to-circle amplification on a digital microfluidic chip for amplified single molecule detection

(2014) Malte Kühnemund et al.   LAB ON A CHIP

Enzyme Molecules in Solitary Confinement

(2014) Raphaela Liebherr et al.   MOLECULES

Dielectrophoresis-Enhanced Plasmonic Sensing with Gold Nanohole Arrays

(2014) Avijit Barik et al.   NANO LETTERS

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Single-molecule methods leap ahead

(2014) Taekjip Ha   NATURE METHODS

Single-molecule evaluation of fluorescent protein photoactivation efficiency using an in vivo nanotemplate

(2014) Nela Durisic et al.   NATURE METHODS

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

(2014) L. Iversen et al.   SCIENCE

Conditional density-based analysis of T cell signaling in single-cell data

(2014) S. Krishnaswamy et al.   SCIENCE

Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states

(2014) Nadine Ehmann et al.   Nature Communications

A graphene-based physiometer array for the analysis of single biological cells

(2014) Geraldine L. C. Paulus et al.   Scientific Reports

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

(2014) Yann Gambin et al.   eLife

Single cell correlation fractal dimension of chromatin

(2014) Vincent Récamier et al.   Nucleus

Direct Detection of Bacterial Genomic DNA at Sub-Femtomolar Concentrations Using Single Molecule Arrays

(2013) Linan Song et al.   ANALYTICAL CHEMISTRY

Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements

(2013) David A. Selck et al.   ANALYTICAL CHEMISTRY

Detection of target-probe oligonucleotide hybridization using synthetic nanopore resistive pulse sensing

(2013) Marsilea Adela Booth et al.   BIOSENSORS & BIOELECTRONICS

Breaking the concentration limit of optical single-molecule detection

(2013) Phil Holzmeister et al.   CHEMICAL SOCIETY REVIEWS

Digital microfluidics-enabled single-molecule detection by printing and sealing single magnetic beads in femtoliter droplets

(2013) Daan Witters et al.   LAB ON A CHIP

Single-molecule interrogation of a bacterial sugar transporter allows the discovery of an extracellular inhibitor

(2013) Lingbing Kong et al.   Nature Chemistry

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics

(2013) Hong-Won Lee et al.   Nature Communications

Nanosensors lost in space. A random walk study of single molecule detection with single-nanopore sensors

(2012) Lajos Höfler et al.   ANALYTICA CHIMICA ACTA

Observation of Electrochemically Controlled Quantum Interference in a Single Anthraquinone-Based Norbornylogous Bridge Molecule

(2012) Nadim Darwish et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single molecule sensing with solid-state nanopores: novel materials, methods, and applications

(2012) Benjamin N. Miles et al.   CHEMICAL SOCIETY REVIEWS

Single Unlabeled Protein Detection on Individual Plasmonic Nanoparticles

(2012) Irene Ament et al.   NANO LETTERS

Conformational states of the kinase Lck regulate clustering in early T cell signaling

(2012) Jérémie Rossy et al.   NATURE IMMUNOLOGY

Integrated nanopore sensing platform with sub-microsecond temporal resolution

(2012) Jacob K Rosenstein et al.   NATURE METHODS

Imaging the electrocatalytic activity of single nanoparticles

(2012) Xiaonan Shan et al.   Nature Nanotechnology

Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod

(2012) Peter Zijlstra et al.   Nature Nanotechnology

Digital Isothermal Quantification of Nucleic Acids via Simultaneous Chemical Initiation of Recombinase Polymerase Amplification Reactions on SlipChip

(2011) Feng Shen et al.   ANALYTICAL CHEMISTRY

Plasmon-Enhanced Colorimetric ELISA with Single Molecule Sensitivity

(2011) Si Chen et al.   NANO LETTERS

Probing cellular protein complexes using single-molecule pull-down

(2011) Ankur Jain et al.   NATURE

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

(2011) David J Williamson et al.   NATURE IMMUNOLOGY

Direct stochastic optical reconstruction microscopy with standard fluorescent probes

(2011) Sebastian van de Linde et al.   Nature Protocols

Thin Layer Coulometry with Ionophore Based Ion-Selective Membranes

(2010) Ewa Grygolowicz-Pawlak et al.   ANALYTICAL CHEMISTRY

A Decade of Systems Biology

(2010) Han-Yu Chuang et al.   Annual Review of Cell and Developmental Biology

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

A single molecule immunoassay by localized surface plasmon resonance

(2010) Kathryn M Mayer et al.   NANOTECHNOLOGY

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

(2010) David M Rissin et al.   NATURE BIOTECHNOLOGY

Single molecule sensing by nanopores and nanopore devices

(2009) Li-Qun Gu et al.   ANALYST

Quantitative Detection of Single Molecules in Fluorescence Microscopy Images

(2009) Eric M. Peterson et al.   ANALYTICAL CHEMISTRY

SlipChip

(2009) Wenbin Du et al.   LAB ON A CHIP

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient

(2009) Meni Wanunu et al.   Nature Nanotechnology

Real-Time Imaging of Single-Molecule Fluorescence with a Zero-Mode Waveguide for the Analysis of Protein−Protein Interaction

(2008) Takeo Miyake et al.   ANALYTICAL CHEMISTRY

In situ Sensing of Single Binding Events by Localized Surface Plasmon Resonance

(2008) Takumi Sannomiya et al.   NANO LETTERS

Fluorescence nanoscopy by ground-state depletion and single-molecule return

(2008) Jonas Fölling et al.   NATURE METHODS

Monitoring dopants by Raman scattering in an electrochemically top-gated graphene transistor

(2008) A. Das et al.   Nature Nanotechnology

Chemically-modified nanopores for sensing

(2008) Róbert E. Gyurcsányi   TRAC-TRENDS IN ANALYTICAL CHEMISTRY