Digital biology and chemistry

Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements

(2013) David A. Selck et al.   ANALYTICAL CHEMISTRY

Ultrasensitivity by Molecular Titration in Spatially Propagating Enzymatic Reactions

(2013) Sergey N. Semenov et al.   BIOPHYSICAL JOURNAL

Chemical Analog-to-Digital Signal Conversion Based on Robust Threshold Chemistry and Its Evaluation in the Context of Microfluidics-Based Quantitative Assays

(2013) Toan Huynh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Stacking nonenzymatic circuits for high signal gain

(2013) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic Volume Modulates Spindle Size During Embryogenesis

(2013) M. C. Good et al.   SCIENCE

Digital Microfluidics

(2012) Kihwan Choi et al.   Annual Review of Analytical Chemistry

Droplet microfluidics for high-throughput biological assays

(2012) Mira T. Guo et al.   LAB ON A CHIP

Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators

(2012) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

Single-cell systems biology by super-resolution imaging and combinatorial labeling

(2012) Eric Lubeck et al.   NATURE METHODS

Digital Isothermal Quantification of Nucleic Acids via Simultaneous Chemical Initiation of Recombinase Polymerase Amplification Reactions on SlipChip

(2011) Feng Shen et al.   ANALYTICAL CHEMISTRY

Quantitative and sensitive detection of rare mutations using droplet-based microfluidics

(2011) Deniz Pekin et al.   LAB ON A CHIP

Isolation and detection of single molecules on paramagnetic beads using sequential fluid flows in microfabricated polymer array assemblies

(2011) Cheuk W. Kan et al.   LAB ON A CHIP

Tomography of Reaction-Diffusion Microemulsions Reveals Three-Dimensional Turing Patterns

(2011) T. Bansagi et al.   SCIENCE

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades

(2011) L. Qian et al.   SCIENCE

Probing Individual Environmental Bacteria for Viruses by Using Microfluidic Digital PCR

(2011) A. D. Tadmor et al.   SCIENCE

Digital PCR on a SlipChip

(2010) Feng Shen et al.   LAB ON A CHIP

A single-molecule enzymatic assay in a directly accessible femtoliter droplet array

(2010) Shouichi Sakakihara et al.   LAB ON A CHIP

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

(2010) David M Rissin et al.   NATURE BIOTECHNOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Microfluidic Confinement of Single Cells of Bacteria in Small Volumes Initiates High-Density Behavior of Quorum Sensing and Growth and Reveals Its Variability

(2009) James Q. Boedicker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Screening individual hybridomas by microengraving to discover monoclonal antibodies

(2009) Adebola O Ogunniyi et al.   Nature Protocols

Rate of Mixing Controls Rate and Outcome of Autocatalytic Processes: Theory and Microfluidic Experiments with Chemical Reactions and Blood Coagulation

(2008) Rebecca R. Pompano et al.   BIOPHYSICAL JOURNAL

Controlled encapsulation of single-cells into monodisperse picolitre drops

(2008) Jon F. Edd et al.   LAB ON A CHIP

Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics

(2008) James Q. Boedicker et al.   LAB ON A CHIP