Mechanistic Insights into the Radical S -adenosyl-l -methionine Enzyme NosL From a Substrate Analogue and the Shunt Products

Substrate-Tuned Catalysis of the RadicalS-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis

(2015) Xinjian Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tryptophan Lyase (NosL): Mechanistic Insights from Substrate Analogues and Mutagenesis

(2015) Dhananjay M. Bhandari et al.   BIOCHEMISTRY

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

(2015) Masaki Horitani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic Versatility and Coordinated Action of 5′-Deoxyadenosyl Radicals in Deazaflavin Biosynthesis

(2015) Benjamin Philmus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigation of the Radical S-Adenosyl-l-methionine Enzyme DesII Using Fluorinated Analogues

(2015) Geng-Min Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural insights into the bacterial carbon–phosphorus lyase machinery

(2015) Paulina Seweryn et al.   NATURE

X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly

(2015) Pedro Dinis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Advances in Radical SAM Enzymology: New Structures and Mechanisms

(2014) Jiarui Wang et al.   ACS Chemical Biology

Mechanistic Studies of the RadicalS-Adenosylmethionine Enzyme DesII with TDP-D-Fucose

(2014) Yeonjin Ko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal Structure of Tryptophan Lyase (NosL): Evidence for Radical Formation at the Amino Group of Tryptophan

(2014) Yvain Nicolet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[FeFe]-Hydrogenase Maturation

(2014) Eric M. Shepard et al.   BIOCHEMISTRY

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

RadicalS-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions

(2014) Angad P. Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversible H Atom Abstraction Catalyzed by the Radical S-Adenosylmethionine Enzyme HydG

(2014) Benjamin R. Duffus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiopeptide Antibiotics: Retrospective and Recent Advances

(2014) Xavier Just-Baringo et al.   Marine Drugs

Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis

(2013) Leif Flühe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The catalytic mechanism for aerobic formation of methane by bacteria

(2013) Siddhesh S. Kamat et al.   NATURE

A Radical Intermediate in Tyrosine Scission to the CO and CN- Ligands of FeFe Hydrogenase

(2013) J. M. Kuchenreuther et al.   SCIENCE

Radical SAM enzymes involved in the biosynthesis of purine-based natural products

(2012) Vahe Bandarian   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Answers to the Carbon-Phosphorus Lyase Conundrum

(2012) Qi Zhang et al.   CHEMBIOCHEM

Covalent Intermediate in the Catalytic Mechanism of the Radical S-Adenosyl-l-methionine Methyl Synthase RlmN Trapped by Mutagenesis

(2012) Kevin P. McCusker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of F0, Precursor of the F420 Cofactor, Requires a Unique Two Radical-SAM Domain Enzyme and Tyrosine as Substrate

(2012) Laure Decamps et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of thiopeptide antibiotics and their pathway engineering

(2012) Qi Zhang et al.   NATURAL PRODUCT REPORTS

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Radical-mediated enzymatic carbon chain fragmentation-recombination

(2011) Qi Zhang et al.   Nature Chemical Biology

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework

(2009) Yi Yu et al.   ACS Chemical Biology

Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli

(2009) Martin R. Challand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY