Thiopeptide Antibiotics: Retrospective and Recent Advances

Inhibition of Renin-Angiotensin System

(2016) Sharma S. Prabhakar   JOURNAL OF INVESTIGATIVE MEDICINE

Total Synthesis and Stereochemical Assignment of Baringolin

(2013) Xavier Just-Baringo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From 2,6-Dichloronicotinic Acid to Thiopeptide Cores

(2013) Xavier Just-Baringo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin

(2013) Sara Palomo et al.   Marine Drugs

The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds

(2013) S. J. Malcolmson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Thiostrepton Was Made in the Laboratory

(2012) K. C. Nicolaou   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection

(2012) Anna Trzasko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action of and Mechanism of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compound LFF571

(2012) J. A. Leeds et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Insights into Quinaldic Acid Moiety Formation in Thiostrepton Biosynthesis Facilitating Fluorinated Thiopeptide Generation

(2012) Lian Duan et al.   CHEMISTRY & BIOLOGY

Codon Randomization for Rapid Exploration of Chemical Space in Thiopeptide Antibiotic Variants

(2012) Travis S. Young et al.   CHEMISTRY & BIOLOGY

Antibiotic Optimization and Chemical Structure Stabilization of Thiomuracin A

(2012) Matthew J. LaMarche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection

(2012) Matthew J. LaMarche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes

(2012) Stéphane Pierre et al.   Nature Chemical Biology

Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS

(2011) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

NMR Structures of Thiostrepton Derivatives for Characterization of the Ribosomal Binding Site

(2011) Hendrik R. A. Jonker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antifungal thiopeptide cyclothiazomycin B1 exhibits growth inhibition accompanying morphological changes via binding to fungal cell wall chitin

(2011) Naoko Mizuhara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of NocL Involved in Thiopeptide Nocathiacin I Biosynthesis

(2011) Qi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids

(2011) Matthew J. LaMarche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Complete Structural Assignment of Thiocillin I

(2011) Virender S. Aulakh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiostrepton Maturation Involving a Deesterification−Amidation Way To Process the C-Terminally Methylated Peptide Backbone

(2011) Rijing Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical-mediated enzymatic carbon chain fragmentation-recombination

(2011) Qi Zhang et al.   Nature Chemical Biology

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

(2011) Nagaratna S. Hegde et al.   Nature Chemistry

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4

(2011) Justin D. Walter et al.   NUCLEIC ACIDS RESEARCH

Synthesis of the Pyridine Core of Cyclothiazomycin

(2011) Yan Zou et al.   ORGANIC LETTERS

Identification of the thiazolyl peptide GE37468 gene cluster fromStreptomycesATCC 55365 and heterologous expression inStreptomyces lividans

(2011) Travis S. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient, multigram and enantiopure synthesis of (S)-2-(2,4′-bithiazol-2-yl)pyrrolidine

(2011) Xavier Just-Baringo et al.   TETRAHEDRON LETTERS

Antiplasmodial Thiostrepton Derivatives: Proteasome Inhibitors with a Dual Mode of Action

(2010) Sebastian Schoof et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isolation and Characterization of the Gene Cluster for Biosynthesis of the Thiopeptide Antibiotic TP-1161

(2010) K. Engelhardt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification and Analysis of the Biosynthetic Gene Cluster Encoding the Thiopeptide Antibiotic Cyclothiazomycin in Streptomyces hygroscopicus 10-22

(2010) J. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species

(2010) K. Engelhardt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin

(2010) Maochen Wei et al.   BIOTECHNOLOGY LETTERS

Novel anticancer compounds induce apoptosis in melanoma cells

(2010) Uppoor G. Bhat et al.   CELL CYCLE

Total Syntheses of the Thiopeptides Amythiamicin C and D

(2010) Carolin Ammer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Expanding the range of ‘druggable’ targets with natural product-based libraries: an academic perspective

(2010) Renato A Bauer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

Thiazolyl Peptide Antibiotic Biosynthesis: A Cascade of Post-translational Modifications on Ribosomal Nascent Proteins

(2010) Christopher T. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of Microbial Resistance to Thiopeptide Antibiotics

(2010) Sascha Baumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide

(2010) Yi Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetic Interception and Structural Characterization of Thiopeptide Cyclization Precursors fromBacillus cereus

(2010) Albert A. Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Manipulation of Thiocillin Variants by Prepeptide Gene Replacement: Structure, Conformation, and Activity of Heterocycle Substitution Mutants

(2010) Albert A. Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099

(2010) Ying Ding et al.   Molecular BioSystems

Micrococcin P1: Structure, biology and synthesis

(2010) Marco A. Ciufolini et al.   NATURAL PRODUCT REPORTS

Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework

(2009) Yi Yu et al.   ACS Chemical Biology

Aza-Wittig-Supported Synthesis of the A Ring of Nosiheptide

(2009) Jin-Yong Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis and Stereochemical Assignment of Micrococcin P1

(2009) David Lefranc et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiopeptide Antibiotic Biosynthesis

(2009) Hans-Dieter Arndt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

(2009) Rijing Liao et al.   CHEMISTRY & BIOLOGY

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

Thiazomycins, Thiazolyl Peptide Antibiotics fromAmycolatopsis fastidiosa

(2009) Chaowei Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Thiostrepton Biosynthesis: Prototype for a New Family of Bacteriocins

(2009) Wendy L. Kelly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

(2009) Rowan P. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in thiopeptideantibiotic biosynthesis

(2009) Chaoxuan Li et al.   NATURAL PRODUCT REPORTS

Highly Efficient Borylation Suzuki Coupling Process for 4-Bromo-2-ketothiazoles: Straightforward Access to Micrococcinate and Saramycetate Esters

(2009) Thibaut Martin et al.   ORGANIC LETTERS

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

(2009) Uppoor G. Bhat et al.   PLoS One

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

(2009) Laura C. Wieland Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa

(2008) Chaowei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism

(2008) Benjamin D. Bowling et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Total syntheses of amythiamicins A, B and C

(2008) K. C. Nicolaou et al.   CHEMICAL COMMUNICATIONS

Concise Total Synthesis of the Thiazolyl Peptide Antibiotic GE2270 A

(2008) Oscar Delgado et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Siomycin A: Construction of Synthetic Segments

(2008) Tomonori Mori et al.   Chemistry-An Asian Journal

Mapping the Binding Site of Thiopeptide Antibiotics by Proximity-Induced Covalent Capture

(2008) Sascha Baumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation, Structure, and Antibacterial Activity of Philipimycin, A Thiazolyl Peptide Discovered fromActinoplanes philippinensisMA7347

(2008) Chaowei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

(2008) J. M-M. Kwok et al.   MOLECULAR CANCER THERAPEUTICS

Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin

(2008) Joerg M. Harms et al.   MOLECULAR CELL

Direct C-2 Arylation of Alkyl 4-Thiazolecarboxylates: New Insights in Synthesis of Heterocyclic Core of Thiopeptide Antibiotics

(2008) Thibaut Martin et al.   ORGANIC LETTERS