A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

From the Structure and Function of the Ribosome to New Antibiotics (Nobel Lecture)

(2010) Thomas A. Steitz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Consensus Mechanism for Radical SAM-Dependent Dehydrogenation? BtrN Contains Two [4Fe-4S] Clusters

(2010) Tyler L. Grove et al.   BIOCHEMISTRY

S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

(2010) Mohamed Atta et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

(2010) Feng Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics

(2010) Michael P.S. Booth et al.   PROTEIN EXPRESSION AND PURIFICATION

Anaerobic functionalization of unactivated C–H bonds

(2009) Squire J Booker   CURRENT OPINION IN CHEMICAL BIOLOGY

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) Katarzyna H. Kaminska et al.   NUCLEIC ACIDS RESEARCH

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

(2008) L. K. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

9-Mercaptodethiobiotin Is Formed as a Competent Catalytic Intermediate byEscherichia coliBiotin Synthase†

(2008) Andrew M. Taylor et al.   BIOCHEMISTRY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY