Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats

Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney

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(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Characterization of pressure-mediated vascular tone in resistance arteries from bile duct-ligated rats

(2017) Ravirajsinh N. Jadeja et al.   Oncotarget

Statins improve NASH via inhibition of RhoA and Ras

(2016) Robert Schierwagen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases

(2016) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

The role of PDGF-D in healthy and fibrotic kidneys

(2016) Eva M. Buhl et al.   KIDNEY INTERNATIONAL

Novel Rat Model of Repetitive Portal Venous Embolization Mimicking Human Non-Cirrhotic Idiopathic Portal Hypertension

(2016) Sabine Klein et al.   PLoS One

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Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis

(2015) Sabine Klein et al.   GUT

β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis

(2015) Peri Kocabayoglu et al.   JOURNAL OF HEPATOLOGY

The carbon tetrachloride model in mice

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Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension

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Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis

(2015) Jan Görtzen et al.   Frontiers in Physiology

ROCK Inhibition Facilitates In Vitro Expansion of Glioblastoma Stem-Like Cells

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Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis

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Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

(2015) Robert Schierwagen et al.   Scientific Reports

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

(2014) Michaela Granzow et al.   HEPATOLOGY

Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections

(2014) Rogelio Barreto et al.   JOURNAL OF HEPATOLOGY

Hyponatremia in Patients with Cirrhosis of the Liver

(2014) Mauro Bernardi et al.   Journal of Clinical Medicine

Activation of the Mas Receptor by Angiotensin-(1–7) in the Renin–Angiotensin System Mediates Mesenteric Vasodilatation in Cirrhosis

(2013) Josephine A. Grace et al.   GASTROENTEROLOGY

Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury

(2013) Justin M. Belcher et al.   HEPATOLOGY

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Platelet-Derived Growth Factor (PDGF)-C Neutralization Reveals Differential Roles of PDGF Receptors in Liver and Kidney Fibrosis

(2012) Ina V. Martin et al.   AMERICAN JOURNAL OF PATHOLOGY

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

(2012) Sabine Klein et al.   JOURNAL OF HEPATOLOGY

Recent advances in our understanding of hepatorenal syndrome

(2012) Florence Wong   Nature Reviews Gastroenterology & Hepatology

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

(2011) Ruchi Bansal et al.   HEPATOLOGY

Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice

(2011) M. M. van Beuge et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis

(2011) Ruchi Bansal et al.   MOLECULAR PHARMACEUTICS

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

(2011) Marike Marjolijn van Beuge et al.   PHARMACEUTICAL RESEARCH

Deleterious effects of beta-blockers on survival in patients with cirrhosis and refractory ascites

(2010) Thomas Sersté et al.   HEPATOLOGY

TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells

(2010) Hideaki Shimada et al.   JOURNAL OF HEPATOLOGY

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

Role of β3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis

(2009) Jonel Trebicka et al.   HEPATOLOGY

The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study

(2009) Jean-Marie Trawalé et al.   LIVER INTERNATIONAL

ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation

(2008) Jieya Shao et al.   FEBS LETTERS

Mechanisms of extrahepatic vasodilation in portal hypertension

(2008) M Hennenberg et al.   GUT

Inhibition of Renal Rho Kinase Attenuates Ischemia/Reperfusion-Induced Injury

(2008) J. Prakash et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY