Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3β Phosphorylation and Oxidative Stress

Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease

(2018) Alice Biosa et al.   ACS Chemical Neuroscience

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)

(2018) Ji‑Dong Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl4-Induced Acute Liver Damage in C57BL/6 Mice

(2018) Zi-Wei Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway

(2018) Min Gi Jo et al.   MOLECULAR NEUROBIOLOGY

Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson’s Disease Model in Mice

(2018) Sugumar Mani et al.   NEUROTOXICITY RESEARCH

Sophora flavescens Aiton Decreases MPP+-Induced Mitochondrial Dysfunction in SH-SY5Y Cells

(2018) Hee-Young Kim et al.   Frontiers in Aging Neuroscience

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress

(2018) Youra Kang et al.   Biomolecules & Therapeutics

Aqueous Extract of Davallia mariesii Attenuates 6-Hydroxydopamine-Induced Oxidative Damage and Apoptosis in B35 Cells Through Inhibition of Caspase Cascade and Activation of PI3K/AKT/GSK-3β Pathway

(2018) Chi-Rei Wu et al.   Nutrients

MPTP Mouse Model of Preclinical and Clinical Parkinson’s Disease as an Instrument for Translational Medicine

(2017) Eduard R. Mingazov et al.   MOLECULAR NEUROBIOLOGY

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans

(2017) Kinga Krzysztoforska et al.   NUTRITIONAL NEUROSCIENCE

Echinacoside ameliorates the memory impairment and cholinergic deficit induced by amyloid beta peptides via the inhibition of amyloid deposition and toxicology

(2017) Young-Ji Shiao et al.   Food & Function

GYY4137, an H2S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson’s Disease

(2017) Xiaoou Hou et al.   Frontiers in Pharmacology

Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells

(2016) Rita Perfeito et al.   ARCHIVES OF TOXICOLOGY

7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressingα-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease

(2016) Xiao-Huan Li et al.   CNS Neuroscience & Therapeutics

Protocatechuic Acid: Inhibition of Fibril Formation, Destabilization of Preformed Fibrils of Amyloid-β and α-Synuclein, and Neuroprotection

(2016) Ruth Hornedo-Ortega et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review

(2016) Xirui He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuroprotective Properties of the Standardized Extract fromCamellia sinensis(Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson’s Disease

(2015) Natália Bitu Pinto et al.   Evidence-based Complementary and Alternative Medicine

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

(2015) Zaijun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine

(2015) Xirui He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Epicatechin Reduces Striatal MPP+-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity

(2015) M. Rubio-Osornio et al.   Oxidative Medicine and Cellular Longevity

Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

(2015) Joseph Shay et al.   Oxidative Medicine and Cellular Longevity

Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease

(2015) Mojtaba Golpich et al.   PHARMACOLOGICAL RESEARCH

Development of a rapid and simple HPLC-UV method for determination of gallic acid in Schinopsis brasiliensis

(2015) Felipe H.A. Fernandes et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Development of a rapid and simple HPLC-UV method for determination of gallic acid in Schinopsis brasiliensis

(2015) Felipe H.A. Fernandes et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

(2014) J J Credle et al.   CELL DEATH AND DIFFERENTIATION

(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy

(2014) Diana Macedo et al.   HUMAN MOLECULAR GENETICS

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease

(2012) Stéphanie Pain et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Therapeutic Attenuation of Neuroinflammation and Apoptosis by Black Tea Theaflavin in Chronic MPTP/Probenecid Model of Parkinson’s Disease

(2012) Annadurai Anandhan et al.   NEUROTOXICITY RESEARCH

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

(2010) Jonathan Wills et al.   EXPERIMENTAL NEUROLOGY

Biochemical alterations of the striatum in an MPTP-treated mouse model of Parkinson’s disease

(2010) Hayato Kuroiwa et al.   METABOLIC BRAIN DISEASE

Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo

(2010) Hong-Ning Zhang et al.   NEUROSCIENCE LETTERS

Effects of Sophora japonica flowers (Huaihua) on cerebral infarction

(2010) Hsiang-Ni Chen et al.   Chinese Medicine

Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin

(2009) Hong-Ning Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. Against focal cerebral ischemia in rats

(2009) S.J. Park et al.   PHYTOMEDICINE

Lavandulyl Flavanones from Sophora flavescens Protect Mouse Hippocampal Cells against Glutamate-Induced Neurotoxicity via the Induction of Heme Oxygenase-1

(2008) Gil-Saeng Jeong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protocatechuic acid inhibits apoptosis by mitochondrial dysfunction in rotenone-induced PC12 cells

(2007) Ye-Ming Liu et al.   TOXICOLOGY IN VITRO