Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

(2017) Xiaohong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maximising the potential of AKT inhibitors as anti-cancer treatments

(2017) Jessica S. Brown et al.   PHARMACOLOGY & THERAPEUTICS

An integrative study on the impact of highly differentially methylated genes on expression and cancer etiology

(2017) Bugra Ozer et al.   PLoS One

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α

(2017) Lauren M. Thorpe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNA-487a Promotes Proliferation and Metastasis in Hepatocellular Carcinoma

(2016) Rui-Min Chang et al.   CLINICAL CANCER RESEARCH

Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target

(2016) U Saini et al.   ONCOGENE

Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes

(2016) Nerea Osinalde et al.   Scientific Reports

NoncatalyticPTENmissense mutation predisposes to organ-selective cancer development in vivo

(2015) Enrico Caserta et al.   GENES & DEVELOPMENT

PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer

(2015) LI-XU YAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway

(2015) Youcheng Lin et al.   Scientific Reports

Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

(2015) Lydia WT Cheung et al.   eLife

Naturally Occurring Neomorphic PIK3R1 Mutations Activate the MAPK Pathway, Dictating Therapeutic Response to MAPK Pathway Inhibitors

(2014) Lydia W.T. Cheung et al.   CANCER CELL

Crosstalking between Androgen and PI3K/AKT Signaling Pathways in Prostate Cancer Cells

(2014) Suk Hyung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRD7, a Tumor Suppressor, Interacts with p85α and Regulates PI3K Activity

(2014) Yu-Hsin Chiu et al.   MOLECULAR CELL

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

(2014) Sandra Van Schaeybroeck et al.   Cell Reports

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

PIK3R1 underexpression is an independent prognostic marker in breast cancer

(2013) Magdalena Cizkova et al.   BMC CANCER

PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line

(2013) SEOK-HO MOON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer

(2013) Y. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

GAB2--a Scaffolding Protein in Cancer

(2012) S. J. Adams et al.   MOLECULAR CANCER RESEARCH

Somatic Mutations of PIK3R1 Promote Gliomagenesis

(2012) Steven N. Quayle et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations

(2011) EUNJU PARK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

(2011) Y Shrestha et al.   ONCOGENE

Essential role of Stat3 in PI3K-induced oncogenic transformation

(2011) Jonathan R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

(2010) C. M. Taniguchi et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

AZ960, a Novel Jak2 Inhibitor, Induces Growth Arrest and Apoptosis in Adult T-Cell Leukemia Cells

(2010) J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Cancer-derived mutations in the regulatory subunit p85  of phosphoinositide 3-kinase function through the catalytic subunit p110 

(2010) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

(2009) Bijay S. Jaiswal et al.   CANCER CELL

Function, regulation and pathological roles of the Gab/DOS docking proteins

(2009) Franziska U Wöhrle et al.   Cell Communication and Signaling

G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation

(2008) Lin Wang et al.   CELLULAR SIGNALLING

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

(2008) Tilman Brummer et al.   EMBO JOURNAL

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT