Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Erythropoietin Stimulates Tumor Growth via EphB4

(2015) Sunila Pradeep et al.   CANCER CELL

Measuring Ovarian Cancer Care: Why Are We Still Failing?

(2015) Barbara Goff   GYNECOLOGIC ONCOLOGY

Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth

(2015) G. Gritsina et al.   MOLECULAR CANCER THERAPEUTICS

Role of malignant ascites on human mesothelial cells and their gene expression profiles

(2014) Isabelle Matte et al.   BMC CANCER

Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread

(2014) Sunila Pradeep et al.   CANCER CELL

A Specific STAT3-Binding Peptide Exerts Antiproliferative Effects and Antitumor Activity by Inhibiting STAT3 Phosphorylation and Signaling

(2014) Daejin Kim et al.   CANCER RESEARCH

HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer

(2014) Kellie S. Rath et al.   CANCER RESEARCH

Doxorubicin Synergizes with 34.5ENVE to Enhance Antitumor Efficacy against Metastatic Ovarian Cancer

(2014) C. Bolyard et al.   CLINICAL CANCER RESEARCH

Bortezomib-Induced Unfolded Protein Response Increases Oncolytic HSV-1 Replication Resulting in Synergistic Antitumor Effects

(2014) J. Y. Yoo et al.   CLINICAL CANCER RESEARCH

Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor

(2014) Brent J. Tierney et al.   GYNECOLOGIC ONCOLOGY

Targeting JAK1/STAT3 Signaling Suppresses Tumor Progression and Metastasis in a Peritoneal Model of Human Ovarian Cancer

(2014) W. Wen et al.   MOLECULAR CANCER THERAPEUTICS

JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells

(2013) P. Kroon et al.   CANCER RESEARCH

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Latest research and treatment of advanced-stage epithelial ovarian cancer

(2013) Robert L. Coleman et al.   Nature Reviews Clinical Oncology

Getting to Know Ovarian Cancer Ascites: Opportunities for Targeted Therapy-Based Translational Research

(2013) Nuzhat Ahmed et al.   Frontiers in Oncology

HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells

(2012) Brent J. Tierney et al.   CANCER BIOLOGY & THERAPY

Leukotriene B4Receptor-2 Promotes Invasiveness and Metastasis of Ovarian Cancer Cells through Signal Transducer and Activator of Transcription 3 (STAT3)-dependent Up-regulation of Matrix Metalloproteinase 2

(2012) Ji-Min Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Characterization of Tumor Cells from the Ascites of Ovarian Cancer Patients: Molecular Phenotype of Chemoresistant Ovarian Tumors

(2012) Ardian Latifi et al.   PLoS One

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells

(2011) Han-Shui Hsu et al.   CANCER

Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties

(2011) Alex Dayton et al.   CANCER BIOLOGY & THERAPY

Synthesis of N-Substituted 3,5-Bis(arylidene)-4-piperidones with High Antitumor and Antioxidant Activity

(2011) Tamás Kálai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

(2010) Xinlai Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer

(2010) Tracy Putoczki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

(2010) Matthew A Bill et al.   Molecular Cancer

HO-3867, a Synthetic Compound, Inhibits the Migration and Invasion of Ovarian Carcinoma Cells through Downregulation of Fatty Acid Synthase and Focal Adhesion Kinase

(2010) K. Selvendiran et al.   MOLECULAR CANCER RESEARCH

Anticancer Efficacy of a Difluorodiarylidenyl Piperidone (HO-3867) in Human Ovarian Cancer Cells and Tumor Xenografts

(2010) K. Selvendiran et al.   MOLECULAR CANCER THERAPEUTICS

Peering into the aftermath: JAKi rips STAT3 in cancer

(2010) Florian R Greten et al.   NATURE MEDICINE

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

(2010) V. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3

(2009) Karuppaiyah Selvendiran et al.   INTERNATIONAL JOURNAL OF CANCER

Knockdown of STAT3 by shRNA inhibits the growth of CAOV3 ovarian cancer cell linein vitroandin vivo

(2008) Feng Huang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA