The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase

A tRNA's fate is decided at its 3′ end: Collaborative actions of CCA-adding enzyme and RNases involved in tRNA processing and degradation

(2018) Karolin Wellner et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Elongator—a tRNA modifying complex that promotes efficient translational decoding

(2018) Marcus J.O. Johansson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cooperativity between different tRNA modifications and their modification pathways

(2018) Mikołaj Sokołowski et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Retina-specific loss of Ikbkap/Elp1 causes mitochondrial dysfunction that leads to selective retinal ganglion cell degeneration in a mouse model of familial dysautonomia

(2018) Yumi Ueki et al.   Disease Models & Mechanisms

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

(2018) Andre Bento-Abreu et al.   HUMAN MOLECULAR GENETICS

Deciphering the reading of the genetic code by near-cognate tRNA

(2018) Sandra Blanchet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Codon-specific translation reprogramming promotes resistance to targeted therapy

(2018) Francesca Rapino et al.   NATURE

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

(2018) Marija Kojic et al.   Nature Communications

Structural asymmetry in the eukaryotic Elongator complex

(2017) Maria I. Dauden et al.   FEBS LETTERS

Thio-Modification of tRNA at the Wobble Position as Regulator of the Kinetics of Decoding and Translocation on the Ribosome

(2017) Namit Ranjan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Permissive zones for the centromere-binding protein ParB on the Caulobacter crescentus chromosome

(2017) Ngat T Tran et al.   NUCLEIC ACIDS RESEARCH

Ribosome dynamics during decoding

(2017) Marina V. Rodnina et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex

(2017) Sophie Laguesse et al.   Frontiers in Cellular Neuroscience

Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator

(2017) Constance Mehlgarten et al.   Toxins

Architecture of the yeast Elongator complex

(2016) Maria I Dauden et al.   EMBO REPORTS

Molecular architecture of the yeast Elongator complex reveals an unexpected asymmetric subunit arrangement

(2016) Dheva T Setiaputra et al.   EMBO REPORTS

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

(2016) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast

(2016) Roland Klassen et al.   NUCLEIC ACIDS RESEARCH

Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

(2016) E. L. Schwalm et al.   SCIENCE

Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code

(2016) Alexey Rozov et al.   Nature Communications

Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi

(2016) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Many Faces of Elongator in Neurodevelopment and Disease

(2016) Marija Kojic et al.   Frontiers in Molecular Neuroscience

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis

(2015) Sophie Laguesse et al.   DEVELOPMENTAL CELL

The importance of being modified: an unrealized code to RNA structure and function

(2015) Paul F. Agris   RNA

Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2

(2015) Sebastian Glatt et al.   STRUCTURE

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

(2014) Kiruthika Selvadurai et al.   Nature Chemical Biology

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

(2013) Stuart C. Howes et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitating the Specificity and Selectivity of Gcn5-Mediated Acetylation of Histone H3

(2013) Yin-Ming Kuo et al.   PLoS One

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

(2013) Boris Zinshteyn et al.   PLoS Genetics

The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase

(2012) Sebastian Glatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Insight into Structure and Assembly of the Nuclear Pore Complex by Utilizing the Genome of a Eukaryotic Thermophile

(2011) Stefan Amlacher et al.   CELL

Human tRNALys3UUU Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto–Enol Tautomerism

(2011) Franck A.P. Vendeix et al.   JOURNAL OF MOLECULAR BIOLOGY

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot

(2011) Katarzyna Miśkiewicz et al.   NEURON

Unexpected Accumulation of ncm5U and ncm5s2U in a trm9 Mutant Suggests an Additional Step in the Synthesis of mcm5U and mcm5s2U

(2011) Changchun Chen et al.   PLoS One

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A role for the elongator complex in zygotic paternal genome demethylation

(2010) Yuki Okada et al.   NATURE

Rapid, nondenaturing RNA purification using weak anion-exchange fast performance liquid chromatography

(2010) L. E. Easton et al.   RNA

Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin

(2009) Catherine Creppe et al.   CELL

Deciphering synonymous codons in the three domains of life: Co-evolution with specific tRNA modification enzymes

(2009) Henri Grosjean et al.   FEBS LETTERS

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents

(2009) Qing Li et al.   PLoS Genetics