PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment

(2018) Belinda van Zyl et al.   ENDOCRINE-RELATED CANCER

Impact of iASPP on chemoresistance through PLK1 and autophagy in ovarian clear cell carcinoma

(2018) Ka-Kui Chan et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DSGOST regulates resistance via activation of autophagy in gastric cancer

(2018) Tae Woo Kim et al.   Cell Death & Disease

Aberrant expression of PDZ-binding kinase/T-LAK cell-originated protein kinase modulates the invasive ability of human pancreatic cancer cells via the stabilization of oncoprotein c-MYC

(2018) Charles P Hinzman et al.   CARCINOGENESIS

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

(2018) Anne Y. Warren et al.   ONCOGENE

T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

(2018) Katharine J. Herbert et al.   Cell Death & Disease

Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis

(2018) Tiantao Gao et al.   CANCER LETTERS

Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase

(2017) Hyung Chul Lee et al.   Cell Death & Disease

T-lymphokine-activated killer cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in glioma

(2017) Chuntao Quan et al.   Oncotarget

Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

(2016) Takuma Ohashi et al.   BRITISH JOURNAL OF CANCER

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

(2016) Y. Ikeda et al.   CLINICAL CANCER RESEARCH

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

PBK/TOPK expression correlates with mutant p53 and affects patients' prognosis and cell proliferation and viability in lung adenocarcinoma

(2015) Bin Lei et al.   HUMAN PATHOLOGY

Overexpression of PDZ-binding kinase confers malignant phenotype in prostate cancer via the regulation of E2F1

(2015) Jia-Hong Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

(2015) Mrinal Joel et al.   Molecular Cancer

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia

(2015) Houda Alachkar et al.   Oncotarget

PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion

(2015) Joshua D. Brown-Clay et al.   Oncotarget

Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells

(2014) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis

(2014) Y. Matsuo et al.   Science Translational Medicine

Novel TOPK Inhibitor HI-TOPK-032 Effectively Suppresses Colon Cancer Growth

(2012) D. J. Kim et al.   CANCER RESEARCH

c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas

(2012) Fang Hu et al.   LEUKEMIA RESEARCH

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics

(2011) Tracey R. O’Donovan et al.   Autophagy

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

(2011) Guangmin Xi et al.   CANCER LETTERS

MicroRNA-30a Sensitizes Tumor Cells to cis-Platinum via Suppressing Beclin 1-mediated Autophagy

(2011) Zhenyou Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer

(2011) M-C Shih et al.   ONCOGENE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Hmbox1 in Endothelial Differentiation of Bone-Marrow Stromal Cells by a Small Molecule

(2010) Le Su et al.   ACS Chemical Biology

PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21

(2010) F Hu et al.   ONCOGENE

Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas

(2009) Lovisa Österberg et al.   BMC CANCER

Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

(2009) Meng Li et al.   BMC Medical Genomics

Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients

(2009) I Zlobec et al.   BRITISH JOURNAL OF CANCER