Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

(2018) Ghanshyam Swarup et al.   Frontiers in Immunology

Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning

(2018) Chikako Harada et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis

(2017) Atsuko Kimura et al.   Oxidative Medicine and Cellular Longevity

Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma

(2017) Kei Akaiwa et al.   Cell Death & Disease

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

(2017) Sandra Torres et al.   Redox Biology

Defects in autophagy caused by glaucoma-associated mutations in optineurin

(2016) Kapil Sirohi et al.   EXPERIMENTAL EYE RESEARCH

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

(2016) Małgorzata Nita et al.   Oxidative Medicine and Cellular Longevity

N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model

(2016) Yasemin Isik Balci et al.   INTERNATIONAL OPHTHALMOLOGY

Caloric restriction promotes cell survival in a mouse model of normal tension glaucoma

(2016) Xiaoli Guo et al.   Scientific Reports

Valproic Acid Prevents NMDA-Induced Retinal Ganglion Cell Death via Stimulation of Neuronal TrkB Receptor Signaling

(2015) Atsuko Kimura et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

(2015) Hongyu Ying et al.   BMC CELL BIOLOGY

Autophagy in axonal degeneration in glaucomatous optic neuropathy

(2015) Yasunari Munemasa et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells

(2014) Wen-jian Lin et al.   Autophagy

Autophagy in the eye: Implications for ocular cell health

(2014) Laura S. Frost et al.   EXPERIMENTAL EYE RESEARCH

Rapamycin Is Neuroprotective in a Rat Chronic Hypertensive Glaucoma Model

(2014) Wenru Su et al.   PLoS One

E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

(2014) Madhavi Latha Somaraju Chalasani et al.   PLoS One

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Renin–angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma

(2014) K Semba et al.   Cell Death & Disease

Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma

(2014) K Semba et al.   Cell Death & Disease

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

(2014) Reza Bavarsad Shahripour et al.   Brain and Behavior

Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1)

(2013) Koji Aoyama et al.   AMINO ACIDS

Meta-analysis: Effectiveness of Drugs for Preventing Contrast-Induced Nephropathy

(2013) Aine M. Kelly et al.   ANNALS OF INTERNAL MEDICINE

M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells

(2013) Kapil Sirohi et al.   Autophagy

The chemistry and biological activities of N-acetylcysteine

(2013) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

(2013) Allen R. Rodriguez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism

(2012) Antonio Y. Hardan et al.   BIOLOGICAL PSYCHIATRY

Glaucoma discrimination of segmented cirrus spectral domain optical coherence tomography (SD-OCT) macular scans

(2012) Jacek Kotowski et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury

(2012) T Katome et al.   CELL DEATH AND DIFFERENTIATION

Acetaminophen and acetylcysteine dose and duration: Past, present and future

(2012) Barry H Rumack et al.   CLINICAL TOXICOLOGY

Antioxidant Status and Oxidative Stress in Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma

(2012) Mesut Erdurmuş et al.   CURRENT EYE RESEARCH

Inhibition of GTRAP3-18 May Increase Neuroprotective Glutathione (GSH) Synthesis

(2012) Koji Aoyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS

(2012) S. Holmseth et al.   JOURNAL OF NEUROSCIENCE

N-acetylcysteine reverses existing cognitive impairment and increased oxidative stress in glutamate transporter type 3 deficient mice

(2012) L. Cao et al.   NEUROSCIENCE

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease

(2012) Anna M. Sadowska   Therapeutic Advances in Respiratory Disease

Global estimates of visual impairment: 2010

(2011) Donatella Pascolini et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial

(2011) Michael Berk et al.   JOURNAL OF AFFECTIVE DISORDERS

Müller Glial Cells in Retinal Disease

(2011) Andreas Bringmann et al.   OPHTHALMOLOGICA

Activation of Autophagy in a Rat Model of Retinal Ischemia following High Intraocular Pressure

(2011) Antonio Piras et al.   PLoS One

Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration

(2011) Chikako Harada et al.   Nature Communications

N-acetylcysteine prevents loss of dopaminergic neurons in theEAAC1−/−mouse

(2010) Ari E. Berman et al.   ANNALS OF NEUROLOGY

ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma

(2010) C Harada et al.   CELL DEATH AND DIFFERENTIATION

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

(2008) Henry Jay Forman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized, Placebo-Controlled Trial

(2008) Michael Berk et al.   BIOLOGICAL PSYCHIATRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE