The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

Soluble Neuregulin1 is strongly up-regulated in the rat model of Charcot-Marie-Tooth 1A disease

(2018) Benedetta Elena Fornasari et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation

(2018) Michela Morano et al.   Scientific Reports

Soluble Neuregulin1 Down-Regulates Myelination Genes in Schwann Cells

(2018) Marwa El Soury et al.   Frontiers in Molecular Neuroscience

The Axon-Myelin Unit in Development and Degenerative Disease

(2018) Ruth M. Stassart et al.   Frontiers in Neuroscience

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

(2018) Judite R. M. Coimbra et al.   Frontiers in Chemistry

Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1

(2018) Amrita Pathak et al.   DEVELOPMENTAL CELL

Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration

(2018) Kasra Tajdaran et al.   EXPERIMENTAL NEUROLOGY

Enhanced axonal Neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model

(2018) Cristina Scapin et al.   HUMAN MOLECULAR GENETICS

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy

(2018) Sophie Belin et al.   HUMAN MOLECULAR GENETICS

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond

(2018) Audrey M Thiebaut et al.   LANCET NEUROLOGY

Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components

(2018) Xinghui Wang et al.   Frontiers in Physiology

After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination

(2017) Jose A. Gomez-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Increased BACE1 activity inhibits peripheral nerve regeneration after injury

(2017) Carolyn Tallon et al.   NEUROBIOLOGY OF DISEASE

Proteolytic processing of Neuregulin-1

(2016) Michael Willem   BRAIN RESEARCH BULLETIN

Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination

(2016) Alessandra Bolino et al.   EMBO Molecular Medicine

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

Functional recovery from sciatic nerve crush injury is delayed because of increased distal atrophy in mice lacking the p75 receptor

(2016) Xiaojuan Chen et al.   NEUROREPORT

Thrombin and protein C pathway in peripheral nerve Schwann cells

(2016) Orna Gera et al.   NEUROSCIENCE

Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination

(2015) So Young Jang et al.   GLIA

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

(2015) Jose A. Gomez-Sanchez et al.   JOURNAL OF CELL BIOLOGY

Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System

(2015) Gerd Meyer zu Horste et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

(2015) X. Hu et al.   JOURNAL OF NEUROSCIENCE

The p75 neurotrophin receptor: at the crossroad of neural repair and death

(2015) RickB Meeker et al.   Neural Regeneration Research

Schwann Cells: Development and Role in Nerve Repair

(2015) Kristján R. Jessen et al.   Cold Spring Harbor Perspectives in Biology

Involvement of Urokinase-Type Plasminogen Activator System in Cancer: An Overview

(2014) Ahmed H. Mekkawy et al.   MEDICINAL RESEARCH REVIEWS

Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

(2014) Robert Fledrich et al.   NATURE MEDICINE

Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination

(2014) Amelia Trimarco et al.   NATURE NEUROSCIENCE

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination

(2013) Florence R. Fricker et al.   BRAIN

Schwann cell phenotype is regulated by axon modality and central–peripheral location, and persists in vitro

(2013) T.M. Brushart et al.   EXPERIMENTAL NEUROLOGY

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels

(2013) Carolyn C. Sachse et al.   FASEB JOURNAL

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

(2012) Brian Hitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Proteasein Vivo

(2012) Lujia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Surface Remodeling by Plasmin: A New Function for an Old Enzyme

(2012) Elena I. Deryugina et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling

(2012) Xavier Fontana et al.   JOURNAL OF CELL BIOLOGY

A role for Schwann cell–derived neuregulin-1 in remyelination

(2012) Ruth M Stassart et al.   NATURE NEUROSCIENCE

c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

(2012) Peter J. Arthur-Farraj et al.   NEURON

The MMP-9/TIMP-1 Axis Controls the Status of Differentiation and Function of Myelin-Forming Schwann Cells in Nerve Regeneration

(2012) Youngsoon Kim et al.   PLoS One

Urokinase Plasminogen Receptor and the Fibrinolytic Complex Play a Role in Nerve Repair after Nerve Crush in Mice, and in Human Neuropathies

(2012) Cristina Rivellini et al.   PLoS One

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination

(2011) Viktorija Velanac et al.   GLIA

Wallerian degeneration: the innate-immune response to traumatic nerve injury

(2011) Shlomo Rotshenker   Journal of Neuroinflammation

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury

(2011) Andrew D Gaudet et al.   Journal of Neuroinflammation

MMP2-9 Cleavage of Dystroglycan Alters the Size and Molecular Composition of Schwann Cell Domains

(2011) F. A. Court et al.   JOURNAL OF NEUROSCIENCE

Reduced BACE1 Activity Enhances Clearance of Myelin Debris and Regeneration of Axons in the Injured Peripheral Nervous System

(2011) M. H. Farah et al.   JOURNAL OF NEUROSCIENCE

Axonally Derived Neuregulin-1 Is Required for Remyelination and Regeneration after Nerve Injury in Adulthood

(2011) F. R. Fricker et al.   JOURNAL OF NEUROSCIENCE

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

(2011) Manuel T Gersbacher et al.   Molecular Neurodegeneration

TACE (ADAM17) inhibits Schwann cell myelination

(2011) Rosa La Marca et al.   NATURE NEUROSCIENCE

Molecular mechanisms regulating myelination in the peripheral nervous system

(2011) Jorge A. Pereira et al.   TRENDS IN NEUROSCIENCES

Reduced Sodium Channel Nav1.1 Levels in BACE1-null Mice

(2010) Doo Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signals to promote myelin formation and repair

(2010) Carla Taveggia et al.   Nature Reviews Neurology

The effects of α-secretase ADAM10 on the proteolysis of neuregulin-1

(2009) Christian Freese et al.   FEBS Journal

Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve

(2009) Parastoo Jangouk et al.   GLIA

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

(2009) Ashwin Woodhoo et al.   NATURE NEUROSCIENCE

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

(2009) Matthew L. Hemming et al.   PLoS One

Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation

(2009) S.-C. Kao et al.   SCIENCE

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Negative regulation of myelination: Relevance for development, injury, and demyelinating disease

(2008) Kristján R. Jessen et al.   GLIA

Roles of Meltrin-β/ADAM19 in Progression of Schwann Cell Differentiation and Myelination during Sciatic Nerve Regeneration

(2008) Shuji Wakatsuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the molecular mechanisms of the fibrinolytic system

(2008) D. C. RIJKEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage

(2008) Hideo Kobayashi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The extracellular matrix affects axonal regeneration in peripheral neuropathies

(2008) S. C. Previtali et al.   NEUROLOGY

Deficiency of Aph1B/C- -secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

(2008) T. Dejaegere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA