Cell Surface Remodeling by Plasmin: A New Function for an Old Enzyme

Activation of Urokinase Plasminogen Activator and Its Receptor Axis Is Essential for Macrophage Infiltration in a Prostate Cancer Mouse Model

(2015) Jian Zhang et al.   NEOPLASIA

Activation of Pro-uPA Is Critical for Initial Escape from the Primary Tumor and Hematogenous Dissemination of Human Carcinoma Cells

(2015) Erin M. Bekes et al.   NEOPLASIA

New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis

(2012) Beate Heissig et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies

(2011) Kenneth A. Botkjaer et al.   BIOCHEMICAL JOURNAL

Regulation of macrophage migration by a novel plasminogen receptor Plg-RKT

(2011) S. Lighvani et al.   BLOOD

Plasminogen Receptor S100A10 Is Essential for the Migration of Tumor-Promoting Macrophages into Tumor Sites

(2011) K. D. Phipps et al.   CANCER RESEARCH

Combating angiogenesis early: potential of targeting tumor-recruited neutrophils in cancer therapy

(2011) James P Quigley et al.   Future Oncology

The Novel Plasminogen Receptor, Plasminogen ReceptorKT(Plg-RKT), Regulates Catecholamine Release

(2011) Hongdong Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b+/F4/80+ myeloid cell recruitment

(2011) M Ishihara et al.   LEUKEMIA

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells

(2011) B Casar et al.   ONCOGENE

Phenotypic Overlap between MMP-13 and the Plasminogen Activation System during Wound Healing in Mice

(2011) Anna Juncker-Jensen et al.   PLoS One

CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis

(2011) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VHLloss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKCδ-driven migration

(2011) Olga V. Razorenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

(2011) J. T. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion

(2010) Daisuke Fujimoto et al.   BMC CANCER

CUB Domain–Containing Protein 1, a Prognostic Factor for Human Pancreatic Cancers, Promotes Cell Migration and Extracellular Matrix Degradation

(2010) Yuri Miyazawa et al.   CANCER RESEARCH

Plasma Fibronectin Promotes Lung Metastasis by Contributions to Fibrin Clots and Tumor Cell Invasion

(2010) Gunjan Malik et al.   CANCER RESEARCH

Skin wound healing in MMP2-deficient and MMP2 / Plasminogen double-deficient mice

(2010) Signe Frøssing et al.   EXPERIMENTAL DERMATOLOGY

Modulators of the urokinase-type plasminogen activation system for cancer

(2010) Ralf Hildenbrand et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ

(2010) Yaowu He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback Regulation of Endothelial Cell Surface Plasmin Generation by PKC-dependent Phosphorylation of Annexin A2

(2010) Kai-Li He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteopontin Is Cleaved at Multiple Sites Close to Its Integrin-binding Motifs in Milk and Is a Novel Substrate for Plasmin and Cathepsin D

(2010) Brian Christensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The generation and characterization of mice expressing a plasmin-inactivating active site mutation

(2010) T. IWAKI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Amplification of the Urokinase-Type Plasminogen Activator Receptor (uPAR) Gene in Ductal Pancreatic Carcinomas Identifies a Clinically High-Risk Group

(2009) Ralf Hildenbrand et al.   AMERICAN JOURNAL OF PATHOLOGY

Comparative Analysis of Metastasis Variants Derived from Human Prostate Carcinoma Cells

(2009) Erin M. Conn et al.   AMERICAN JOURNAL OF PATHOLOGY

Plasmin-Mediated Degradation of Laminin γ-1 Is Critical for Ethanol-Induced Neurodegeneration

(2009) Anna E. Skrzypiec et al.   BIOLOGICAL PSYCHIATRY

Enolase-1 as a plasminogen receptor

(2009) E. F. Plow et al.   BLOOD

Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation

(2009) N. M. Andronicos et al.   BLOOD

Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung

(2009) M. Wygrecka et al.   BLOOD

Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis

(2009) E. Yang et al.   CANCER RESEARCH

Thrombin-Activated Receptors: Promising Targets for Cancer Therapy?

(2009) M. Garcia-Lopez et al.   CURRENT MEDICINAL CHEMISTRY

Urokinase plasminogen activator system as a potential target for cancer therapy

(2009) Ahmed H Mekkawy et al.   Future Oncology

The cell surface glycoprotein CDCP1 in cancer-Insights, opportunities, and challenges

(2009) Andreas Wortmann et al.   IUBMB LIFE

The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR2A Subunit to Relieve Zinc Inhibition of theN-Methyl-d-aspartate Receptors

(2009) Hongjie Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil MMP-9 Proenzyme, Unencumbered by TIMP-1, Undergoes Efficient Activationin Vivoand Catalytically Induces Angiogenesis via a Basic Fibroblast Growth Factor (FGF-2)/FGFR-2 Pathway

(2009) Veronica C. Ardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of the fibrinolytic pathway to hematopoietic regeneration

(2009) Beate Heissig et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells

(2009) Marc Tjwa et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasminogen Enhances Neuritogenesis on Laminin-1

(2009) A. Gutierrez-Fernandez et al.   JOURNAL OF NEUROSCIENCE

Feasibility of Measuring the Prognostic Factors uPA and PAI-1 in Core Needle Biopsy Breast Cancer Specimens

(2009) Christoph Thomssen et al.   JNCI-Journal of the National Cancer Institute

Functional Role of Cell Surface CUB Domain-Containing Protein 1 in Tumor Cell Dissemination

(2009) E. I. Deryugina et al.   MOLECULAR CANCER RESEARCH

Plasticity of NMDA receptor NR2B subunit in memory and chronic pain

(2009) Min Zhuo   Molecular Brain

CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma

(2008) Takamasa Uekita et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Effect of anti-fibrinolytic therapy on experimental melanoma metastasis

(2008) Jennifer M. Kirstein et al.   CLINICAL & EXPERIMENTAL METASTASIS

Activation of pro-BDNF by the pericellular serine protease plasmin

(2008) Kelly Gray et al.   FEBS LETTERS

The Interaction of Streptococcus pneumoniae with Plasmin Mediates Transmigration across Endothelial and Epithelial Monolayers by Intercellular Junction Cleavage

(2008) C. Attali et al.   INFECTION AND IMMUNITY

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Novel Mode of Intervention with Serine Protease Activity

(2008) Grant E. Blouse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma

(2008) Yasuo Awakura et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor

(2008) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation

(2008) Marc Tjwa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice

(2008) Yanqing Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Surface trafficking of N-methyl-d-aspartate receptors: Physiological and pathological perspectives

(2008) L. Groc et al.   NEUROSCIENCE

Plasminogen Activation–Induced Pericellular Fibronectin Proteolysis Promotes Fibroblast Apoptosis

(2007) Jeffrey C. Horowitz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY