Water-Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4-Oxadiazoles

Copper Nitrate Mediated Regioselective [2+2+1] Cyclization of Alkynes with Alkenes: A Cascade Approach to Δ2-Isoxazolines

(2015) Mingchun Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of variously functionalized nitrile oxides

(2015) Haruyasu Asahara et al.   Beilstein Journal of Organic Chemistry

Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors

(2015) Jian Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of the structure–activity relationship of 1,2,4-oxadiazole antibiotics

(2015) Derong Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents

(2015) Cheng-Shi Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

(2015) Maria Grazia Perrone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimycobacterial activity of natural products and synthetic agents: Pyrrolodiquinolines and vermelhotin as anti-tubercular leads against clinical multidrug resistant isolates of Mycobacterium tuberculosis

(2015) Dakshina U. Ganihigama et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins

(2015) Kui-Yong Dong et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Bis(oxazoline) Ligands Possessing C-5 gem-Disubstitution and Their Application in Asymmetric Friedel–Crafts Alkylations

(2015) Steven O’Reilly et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and biological evaluation of novel Δ2-isoxazoline fused cyclopentane derivatives as potential antimicrobial and anticancer agents

(2015) Santosh Kumar Prajapti et al.   MedChemComm

The origin of regio- and stereoselectivity in the 1,3-dipolar cycloaddition of nitrile oxides with C1-substituted 7-oxabenzonorbornadienes, a DFT study

(2015) J. Tajabadi et al.   RSC Advances

1,3-Dipolar cycloaddition of nitrile oxides with C1-substituted 7-oxabenzonorbornadienes

(2014) Jaipal R. Nagireddy et al.   CANADIAN JOURNAL OF CHEMISTRY

Silver-mediated radical cyclization: construction of Δ2-isoxazolines from α-halo ketoximes and 1,3-dicarbonyl compounds

(2014) Yan-Yun Liu et al.   CHEMICAL COMMUNICATIONS

Ruthenium-Catalyzed Cycloadditions of 1-Haloalkynes with Nitrile Oxides and Organic Azides: Synthesis of 4-Haloisoxazoles and 5-Halotriazoles

(2014) James S. Oakdale et al.   CHEMISTRY-A EUROPEAN JOURNAL

Isoxazoline containing natural products as anticancer agents: A review

(2014) Kamalneet Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antimycobacterial activity of various 3-(4-(substitutedsulfonyl)piperazin-1-yl)benzo[d]isoxazole derivatives

(2014) Kalaga Mahalakshmi Naidu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

(2014) Paolo Fagone et al.   IMMUNOLOGY

Copper-Catalyzed Oxyazidation of Unactivated Alkenes: A Facile Synthesis of Isoxazolines Featuring an Azido Substituent

(2014) Liping Zhu et al.   ORGANIC LETTERS

Synthesis of 3,5-disubstituted 1,2,4-oxadiazoles and their behavior of liquid crystallines

(2014) Jian Guo et al.   TETRAHEDRON LETTERS

An environmentally benign synthesis of isoxazolines and isoxazoles mediated by potassium chloride in water

(2014) Liuquan Han et al.   TETRAHEDRON LETTERS

An organocatalyst from renewable materials for the synthesis of coumarins and chromenes: three-component reaction and multigram scale synthesis

(2014) Rapeepat Sangsuwan et al.   RSC Advances

DFT Study of a 5-endo-trig-Type Cyclization of 3-Alkenoic Acids by Using Pd-Spiro-bis(isoxazoline) as Catalyst: Importance of the Rigid Spiro Framework for Both Selectivity and Reactivity

(2013) Randa K. Gabr et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reaction of Nitrile Oxides with Maskedo-Benzoquinones; Synthesis of Highly Functionalized Isoxazolines

(2013) Santhosh Kumar Chittimalla et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Iodine(III)-Mediated [3 + 2] Cyclization for One-Pot Synthesis of Benzo[d]isoxazole-4,7-diols in Aqueous Medium

(2013) Yingwei Hou et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists

(2012) Ajay Soni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles

(2012) Abdulrahman I. Almansour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitrile Oxide/Alkyne Cycloadditions - A Credible Platform for Synthesis of Bioinspired Molecules by Metal-Free Molecular Clicking

(2012) Frances Heaney   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Trisubstituted Isoxazoles by Palladium(II)-Catalyzed Cascade Cyclization–Alkenylation of 2-Alkyn-1-one O-Methyl Oximes

(2012) Zhigang She et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient assembly of 3-substituted oxindole-based isoxazolines leading to the synthesis of (±)-flustraminol-B and related natural product building blocks

(2012) Anand Singh et al.   TETRAHEDRON LETTERS

Divergent reactivity of α-oximino carbenoids: facile access to 2-isoxazolines and 2H-azirines

(2011) Xinxin Qi et al.   CHEMICAL COMMUNICATIONS

Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors

(2011) Clelia Dallanoce et al.   ChemMedChem

N-Heterocyclic carbene-catalyzed 1,3-dipolar cycloaddition reactions: a facile synthesis of 3,5-di- and 3,4,5-trisubstituted isoxazoles

(2011) Shravankumar Kankala et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide

(2011) Nagatoshi Nishiwaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles

(2011) Nagatoshi Nishiwaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction

(2010) Kazutaka Matoba et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels

(2009) Yoshihisa Ozoe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polyketide Building Blocks via Diastereoselective Nitrile Oxide Cycloadditions with Homoallylic Alcohols and Monoprotected Homoallylic Diols

(2009) Nina Lohse-Fraefel et al.   CHEMISTRY-A EUROPEAN JOURNAL

The new era of 1,2,4-oxadiazoles

(2009) Andrea Pace et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Free “Click” Modification of DNA via Nitrile Oxide−Norbornene 1,3-Dipolar Cycloaddition

(2009) Katrin Gutsmiedl et al.   ORGANIC LETTERS

Carbohydrate-based spiro bis(isoxazolines): synthesis and evaluation in asymmetric catalysis

(2009) David Goyard et al.   TETRAHEDRON LETTERS

Ruthenium-Catalyzed Cycloaddition of Nitrile Oxides and Alkynes: Practical Synthesis of Isoxazoles

(2008) Scott Grecian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION