期刊
SCIENCE SIGNALING
卷 12, 期 574, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.aau2293
关键词
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资金
- NIH [HL34303, HL25785]
- Wellcome Trust [094143/Z/10/Z, 203014/Z/16/Z]
- British Heart Foundation [RG/12/11/29815]
- European Research Council
- Royal Society
- Deutsche Forschungsgemeinschaft [CRC1181]
- Else Kroner-Fresenius Stiftung [2013_A274]
- European Union, European Research Council [StG 640087-SOS]
- Wellcome Trust [203014/Z/16/Z, 094143/Z/10/Z] Funding Source: Wellcome Trust
Enzymatically oxidized phospholipids (eoxPLs) are formed through regulated processes by which eicosanoids or prostaglandins are attached to phospholipids (PLs) in immune cells. These eoxPLs comprise structurally diverse families of biomolecules with potent bioactivities, and they have important immunoregulatory roles in both health and disease. The formation of oxPLs through enzymatic pathways and their signaling capabilities are emerging concepts. This paradigm is changing our understanding of eicosanoid, prostaglandin, and PL biology in health and disease. eoxPLs have roles in cellular events such as ferroptosis, apoptosis, and blood clotting and diseases such as arthritis, diabetes, and cardiovascular disease. They are increasingly recognized as endogenous bioactive mediators and potential targets for drug development. This review will describe recent evidence that places eoxPLs and their biosynthetic pathways center stage in immunoregulation.
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