Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQQ209L-driven melanoma

Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles

(2015) Christian Posch et al.   BIOMEDICAL MICRODEVICES

Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice

(2015) J. L.-Y. Huang et al.   CANCER RESEARCH

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Biology of advanced uveal melanoma and next steps for clinical therapeutics

(2014) Jason J. Luke et al.   Pigment Cell & Melanoma Research

Intra-Lesional Injection of the Novel PKC Activator EBC-46 Rapidly Ablates Tumors in Mouse Models

(2014) Glen M. Boyle et al.   PLoS One

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein   subunits

(2013) P. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

(2013) Katerina Sidera et al.   Recent Patents on Anti-Cancer Drug Discovery

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Ric-8a, a Guanine Nucleotide Exchange Factor for Heterotrimeric G Proteins, Regulates Bergmann Glia-Basement Membrane Adhesion during Cerebellar Foliation

(2012) S. Ma et al.   JOURNAL OF NEUROSCIENCE

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

ARID1A, a Factor That Promotes Formation of SWI/SNF-Mediated Chromatin Remodeling, Is a Tumor Suppressor in Gynecologic Cancers

(2011) B. Guan et al.   CANCER RESEARCH

GqProtein-induced Apoptosis Is Mediated by AKT Kinase Inhibition That Leads to Protein Kinase C-induced c-Jun N-terminal Kinase Activation

(2011) Ido Ben-Ami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistance to Inhibitors of Cholinesterase-8A (Ric-8A) Is Critical for Growth Factor Receptor-induced Actin Cytoskeletal Reorganization

(2011) Limin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice

(2011) K. Y. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein   Subunit Membrane Association

(2011) M. Gabay et al.   Science Signaling

Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish

(2010) C. Mosimann et al.   DEVELOPMENT

Nucleotide exchange factor RIC-8 is indispensable in mammalian early development

(2010) Tambet Tõnissoo et al.   DEVELOPMENTAL DYNAMICS

Purification of Heterotrimeric G Protein α Subunits by GST-Ric-8 Association

(2010) PuiYee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

12-O-Tetradecanoylphorbol-13-acetate Inhibits Melanoma Growth by Inactivation of STAT3 through Protein Kinase C-activated Tyrosine Phosphatase(s)

(2009) Masahiro Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma

(2008) Y Ohtani et al.   ONCOGENE