Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq

(2012) Merel J.W. Adjobo-Hermans et al.   CELLULAR SIGNALLING

Real-time visualization of heterotrimeric G protein Gq activation in living cells

(2011) Merel JW Adjobo-Hermans et al.   BMC BIOLOGY

Bypassing GPCRs with Chemical Dimerizers

(2011) J. Goedhart et al.   CHEMISTRY & BIOLOGY

Switching Heterotrimeric G Protein Subunits with a Chemical Dimerizer

(2011) Mateusz Putyrski et al.   CHEMISTRY & BIOLOGY

p63RhoGEF Couples G αq/11 -Mediated Signaling to Ca 2+ Sensitization of Vascular Smooth Muscle Contractility

(2011) Ko Momotani et al.   CIRCULATION RESEARCH

Plasma Membrane Association of p63 Rho Guanine Nucleotide Exchange Factor (p63RhoGEF) Is Mediated by Palmitoylation and Is Required for Basal Activity in Cells

(2011) Mohamed Aittaleb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

Gαq allosterically activates and relieves autoinhibition of p63RhoGEF

(2010) Aruna Shankaranarayanan et al.   CELLULAR SIGNALLING

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Analysis of Protein Complex Hierarchy in Living Cells

(2008) Alen Piljić et al.   ACS Chemical Biology

PKC  mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling

(2008) D. S. Verbeek et al.   JOURNAL OF CELL SCIENCE

Regulation of PLC 1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate

(2008) M. J. W. Adjobo-Hermans et al.   JOURNAL OF CELL SCIENCE

MLK3 Limits Activated Gαq Signaling to Rho by Binding to p63RhoGEF

(2008) Katherine I. Swenson-Fields et al.   MOLECULAR CELL

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE