Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid–Mediated Troglitazone Hepatotoxicity

(2014) K Yang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

(2013) Sabine Schulz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

(2013) Lisl K. M. Shoda et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Association of CYP2C9*2 With Bosentan-Induced Liver Injury

(2013) S M Markova et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates

(2013) Sagnik Chatterjee et al.   TOXICOLOGY IN VITRO

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

(2010) T. Yoshikado et al.   MOLECULAR PHARMACOLOGY

An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

(2009) J. H. Ansede et al.   DRUG METABOLISM AND DISPOSITION

Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

(2009) E. Kis et al.   DRUG METABOLISM AND DISPOSITION

The enterohepatic circulation of bile acids in mammals: form and functions

(2009) Alan et al.   Frontiers in Bioscience-Landmark

Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714

(2009) Bo Feng et al.   TOXICOLOGICAL SCIENCES

Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes

(2008) Birthe Lauer et al.   CHEMICO-BIOLOGICAL INTERACTIONS