PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy

(2017) Weiquan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane

(2017) Deepti Karandur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drugging RAS: Know the enemy

(2017) Bjoern Papke et al.   SCIENCE

ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma

(2016) Jae Hyuk Yoo et al.   CANCER CELL

Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain

(2016) Luke R. Odell et al.   JOURNAL OF MEDICINAL CHEMISTRY

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

(2016) Giulia Mana et al.   Nature Communications

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

(2015) Massiullah Shafaq-Zadah et al.   NATURE CELL BIOLOGY

A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1

(2015) Kaycie M. Deyle et al.   Nature Chemistry

Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains

(2015) Ivana Vonkova et al.   Cell Reports

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

(2014) D. Padovani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

The Human Plasma Membrane Peripherome: Visualization and Analysis of Interactions

(2014) Katerina C. Nastou et al.   Biomed Research International

Targeting Protein-Protein Interaction by Small Molecules

(2013) Lingyan Jin et al.   Annual Review of Pharmacology and Toxicology

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

(2013) E. Charafe-Jauffret et al.   CANCER RESEARCH

Small G Proteins in the Cardiovascular System: Physiological and Pathological Aspects

(2013) Gervaise Loirand et al.   PHYSIOLOGICAL REVIEWS

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

(2013) Kaheina Aizel et al.   PLOS BIOLOGY

The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts

(2012) Christine Dottermusch-Heidel et al.   DEVELOPMENTAL BIOLOGY

The Pleckstrin Homology (PH) Domain of the Arf Exchange Factor Brag2 Is an Allosteric Binding Site

(2012) Xiaoying Jian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRAG2/GEP100/IQSec1 Interacts with Clathrin and Regulates α5β1 Integrin Endocytosis through Activation of ADP Ribosylation Factor 5 (Arf5)

(2012) Radim Moravec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Pleckstrin Homology Domain of Akt Kinase: A Proof of Principle for Highly Specific and Effective Non-Enzymatic Anti-Cancer Target

(2012) Eun-Ha Joh et al.   PLoS One

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Chronicles of the GTPase switch

(2011) Jacqueline Cherfils et al.   Nature Chemical Biology

Bacterial protein toxins that modify host regulatory GTPases

(2011) Klaus Aktories   NATURE REVIEWS MICROBIOLOGY

ARF family G proteins and their regulators: roles in membrane transport, development and disease

(2011) Julie G. Donaldson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPA Receptor Signaling through BRAG2 and Arf6 Critical for Long-Term Synaptic Depression

(2010) Ralf Scholz et al.   NEURON

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

(2010) Wen-I Wu et al.   PLoS One

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY