Small G Proteins in the Cardiovascular System: Physiological and Pathological Aspects

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension

(2012) Chrystelle Cario-Toumaniantz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels

(2012) Junko Sawada et al.   CANCER CELL

An ARF6/Rab35 GTPase Cascade for Endocytic Recycling and Successful Cytokinesis

(2012) Laurent Chesneau et al.   CURRENT BIOLOGY

SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton

(2012) Y. Langdon et al.   DEVELOPMENT

Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1

(2012) Xiangsheng Yang et al.   FASEB JOURNAL

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

Proteomic Profiling of H-Ras-G12V Induced Hypertrophic Cardiomyopathy in Transgenic Mice Using Comparative LC-MS Analysis of Thin Fresh-Frozen Tissue Sections

(2012) Bih-Rong Wei et al.   JOURNAL OF PROTEOME RESEARCH

Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42

(2012) Justin Lengfeld et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition and Termination of Physiological Responses by GTPase Activating Proteins

(2012) Erzsébet Ligeti et al.   PHYSIOLOGICAL REVIEWS

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Neurocognitive, adaptive, and behavioral functioning of individuals with Costello syndrome: A review

(2011) Marni E. Axelrad et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels

(2011) Jabe M. Best et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The significance of regulatory light chain phosphorylation in cardiac physiology

(2011) Sarah B. Scruggs et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Induction of Smooth Muscle Cell Migration During Arteriogenesis Is Mediated by Rap2

(2011) Jochen Pöling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cdc42 Controls Vascular Network Assembly Through Protein Kinase Cι During Embryonic Vasculogenesis

(2011) Yanmei Qi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase

(2011) Zhongcui Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rho–Rho Kinase Pathway Is Involved in the Protective Effect of Early Ischemic Preconditioning in the Rat Heart

(2011) Kenji Sakamoto et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Rabs and other small GTPases in ciliary transport

(2011) Yi Shan Lim et al.   BIOLOGY OF THE CELL

Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin  v 3

(2011) S. Lakshmikanthan et al.   BLOOD

Cyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression

(2011) K. R. Chava et al.   BLOOD

Role of p115RhoGEF in lipopolysaccharide-induced mouse brain microvascular endothelial barrier dysfunction

(2011) Deng Xiaolu et al.   BRAIN RESEARCH

Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctions

(2011) Mehran Haidari et al.   CARDIOVASCULAR RESEARCH

Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor

(2011) Ji Zhang et al.   CARDIOVASCULAR RESEARCH

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Pak1 as a Novel Therapeutic Target for Antihypertrophic Treatment in the Heart

(2011) Wei Liu et al.   CIRCULATION

p63RhoGEF Couples G αq/11 -Mediated Signaling to Ca 2+ Sensitization of Vascular Smooth Muscle Contractility

(2011) Ko Momotani et al.   CIRCULATION RESEARCH

Vesicle Trafficking: A Rab Family Profile

(2011) Kathryn P. Harris et al.   CURRENT BIOLOGY

Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo

(2011) I. Migeotte et al.   DEVELOPMENT

Angiogenic Sprouting Requires the Fine Tuning of Endothelial Cell Cohesion by the Raf-1/Rok-α Complex

(2011) Reiner Wimmer et al.   DEVELOPMENTAL CELL

Ran-dependent nuclear export mediators: a structural perspective

(2011) Thomas Güttler et al.   EMBO JOURNAL

Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II

(2011) Hiroshi Kamijo et al.   GENES TO CELLS

Novel Role of Rac1/WAVE Signaling Mechanism in Regulation of the Epithelial Na + Channel

(2011) Alexey V. Karpushev et al.   HYPERTENSION

RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits

(2011) Hiroshi Ohkawara et al.   Journal of Atherosclerosis and Thrombosis

Vav Family Rho Guanine Nucleotide Exchange Factors Regulate CD36-mediated Macrophage Foam Cell Formation

(2011) S. Ohidar Rahaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity

(2011) Bartosz J. Zieba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species

(2011) Li Qian et al.   JOURNAL OF CELL BIOLOGY

RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac

(2011) Minzhou Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost

(2011) Anna A. Birukova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor–dependent pathway

(2011) Shigeru Shibata et al.   JOURNAL OF CLINICAL INVESTIGATION

RhoA protects the mouse heart against ischemia/reperfusion injury

(2011) Sunny Yang Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases?

(2011) Jing Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

The in-situ pig heart with regional ischemia/reperfusion — Ready for translation

(2011) Gerd Heusch et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction

(2011) Jing Peng et al.   Journal of Neuroinflammation

Spectrum of Mutations in Noonan Syndrome and Their Correlation with Phenotypes

(2011) Beom Hee Lee et al.   JOURNAL OF PEDIATRICS

Rheb Is Essential for Murine Development

(2011) S. M. I. Goorden et al.   MOLECULAR AND CELLULAR BIOLOGY

A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions

(2011) Jian J. Liu et al.   MOLECULAR BIOLOGY OF THE CELL

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

(2011) Anchal Chandra et al.   NATURE CELL BIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Statin Therapy for the Prevention of Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials

(2011) Zhongsu Wang et al.   PHARMACOTHERAPY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome

(2011) J. Urosevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROCK in a Stiff Place

(2011) D. A. Lauffenburger   Science Translational Medicine

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

(2011) J. Huynh et al.   Science Translational Medicine

Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes

(2010) Katsuya Kajimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Blockade of the Ras–Extracellular Signal–Regulated Kinase 1/2 Pathway Is Involved in Smooth Muscle 22α–Mediated Suppression of Vascular Smooth Muscle Cell Proliferation and Neointima Hyperplasia

(2010) Li-Hua Dong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation

(2010) Matt D. Medlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pleiotropic Effects of Statins

(2010) Qian Zhou et al.   CIRCULATION JOURNAL

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4

(2010) Fumiyuki Sanematsu et al.   CIRCULATION RESEARCH

Activation of PKN Mediates Survival of Cardiac Myocytes in the Heart During Ischemia/Reperfusion

(2010) Hiromitsu Takagi et al.   CIRCULATION RESEARCH

Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited Ca V 1.2 Channels in Heart

(2010) Xianghua Xu et al.   CIRCULATION RESEARCH

Deletion of ABCA1 and ABCG1 Impairs Macrophage Migration Because of Increased Rac1 Signaling

(2010) Tamara A. Pagler et al.   CIRCULATION RESEARCH

Novel aspects of the roles of Rac1 GTPase in the cardiovascular system

(2010) Naoki Sawada et al.   CURRENT OPINION IN PHARMACOLOGY

Farnesyltransferase inhibitors: where are we now?

(2010) Apostolia Maria Tsimberidou et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

p63RhoGEF—a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells

(2010) Christina M. Wuertz et al.   FASEB JOURNAL

Disruption of Rac1 signaling reduces ischemia–reperfusion injury in the diabetic heart by inhibiting calpain

(2010) Limei Shan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Clinical and genetic aspects of neurofibromatosis 1

(2010) Kimberly Jett et al.   GENETICS IN MEDICINE

Targeted Genomic Disruption of H-Ras Induces Hypotension Through a NO-cGMP-PKG Pathway–Dependent Mechanism

(2010) Aranzazu Chamorro-Jorganes et al.   HYPERTENSION

Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome

(2010) Toshiro Fujita   HYPERTENSION

Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype

(2010) Asya L. Borikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lbc Rho Guanine Nucleotide Exchange Factor/α-Catulin Axis Functions in Serotonin-induced Vascular Smooth Muscle Cell Mitogenesis and RhoA/ROCK Activation

(2010) Michael D. Bear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rho Guanine Nucleotide Exchange Factor AKAP13 (BRX) Is Essential for Cardiac Development in Mice

(2010) Chantal M. Mayers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrical Activation of Sinus Venosus Myocardium and Expression Patterns of RhoA and Isl-1 in the Chick Embryo

(2010) REBECCA VICENTE-STEIJN et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

R-Ras interacts with filamin a to maintain endothelial barrier function

(2010) G.S. Griffiths et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

(2010) Elisabeth A. Lasater et al.   JOURNAL OF CLINICAL INVESTIGATION

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

(2010) Dominic P. Del Re et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of Rho–ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase

(2010) Paul A.J. Krijnen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

(2010) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase

(2010) Tingting Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rac1-Induced Connective Tissue Growth Factor Regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation

(2010) Oliver Adam et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelin-1 Inhibits the Epithelial Na+ Channel through  Pix/14-3-3/Nedd4-2

(2010) T. S. Pavlov et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression

(2010) K. Kuwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

AS160 Modulates Aldosterone-stimulated Epithelial Sodium Channel Forward Trafficking

(2010) Xiubin Liang et al.   MOLECULAR BIOLOGY OF THE CELL

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

(2010) Christophe Guilluy et al.   NATURE MEDICINE

The role of Rho protein signaling in hypertension

(2010) Gervaise Loirand et al.   Nature Reviews Cardiology

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Noonan Syndrome: Clinical Features, Diagnosis, and Management Guidelines

(2010) A. A. Romano et al.   PEDIATRICS

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

(2010) Beth A. Rose et al.   PHYSIOLOGICAL REVIEWS

Intact Cytoskeleton Is Required for Small G Protein Dependent Activation of the Epithelial Na+ Channel

(2010) Alexey V. Karpushev et al.   PLoS One

ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes

(2010) Andrew K. Marshall et al.   PLoS One

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

(2010) G. Buhrman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K Signaling Through the Dual GTPase-Activating Protein ARAP3 Is Essential for Developmental Angiogenesis

(2010) L. Gambardella et al.   Science Signaling

GTPases involved in vesicular trafficking: Structures and mechanisms

(2010) Aymelt Itzen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of angiogenesis by a small GTPase Rap1

(2010) Magdalena Chrzanowska-Wodnicka   VASCULAR PHARMACOLOGY

Signaling mechanisms of angiotensin II in regulating vascular senescence

(2009) Li-Juan Min et al.   AGEING RESEARCH REVIEWS

PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes

(2009) Quan He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of protein tyrosine phosphatase SHP2 in barrier function of pulmonary endothelium

(2009) K. L. Grinnell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PYK2/PDZ-RhoGEF Links Ca 2+ Signaling to RhoA

(2009) Zhekang Ying et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ras inhibition attenuates myocardial ischemia–reperfusion injury

(2009) Rakefet Pando et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of the Substrate Preference of p190RhoGAP by Protein Kinase C-Mediated Phosphorylation of a Phospholipid Binding Site

(2009) Magdolna Lévay et al.   BIOCHEMISTRY

Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins

(2009) Michel R. Popoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis

(2009) G. Wei et al.   BLOOD

LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells

(2009) Koichi Sugimoto et al.   CARDIOVASCULAR RESEARCH

Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy

(2009) Delvac Oceandy et al.   CIRCULATION

Importance of Rac1 Signaling Pathway Inhibition in the Pleiotropic Effects of HMG-CoA Reductase Inhibitors

(2009) Mamunur Rashid et al.   CIRCULATION JOURNAL

3-Deazaadenosine Prevents Smooth Muscle Cell Proliferation and Neointima Formation by Interfering With Ras Signaling

(2009) Daniel G. Sedding et al.   CIRCULATION RESEARCH

Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction

(2009) Junwang Xu et al.   CIRCULATION RESEARCH

ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells

(2009) Yuepeng Wang et al.   CIRCULATION RESEARCH

Rad As a Novel Regulator of Excitation–Contraction Coupling and β-Adrenergic Signaling in Heart

(2009) Gang Wang et al.   CIRCULATION RESEARCH

Rho Kinase: An Important Mediator of Atherosclerosis and Vascular Disease

(2009) Qian Zhou et al.   CURRENT PHARMACEUTICAL DESIGN

Regulation of lymphatic-blood vessel separation by endothelial Rac1

(2009) G. D'Amico et al.   DEVELOPMENT

Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation

(2009) Ke Xu et al.   DEVELOPMENTAL BIOLOGY

Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

(2009) G. Boulday et al.   Disease Models & Mechanisms

α-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

(2009) Eloi Montanez et al.   EMBO JOURNAL

Endothelial signaling in paracellular and transcellular leukocyte transmigration

(2009) Erika et al.   Frontiers in Bioscience-Landmark

Cardiac ion channels in health and disease

(2009) Ahmad S. Amin et al.   HEART RHYTHM

Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/βPIX/Rac-1 Pathway

(2009) Carmine Vecchione et al.   HYPERTENSION

Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor

(2009) Matthias Löhn et al.   HYPERTENSION

p21-Activated Kinase 1 Participates in Vascular Remodeling In Vitro and In Vivo

(2009) Akinari Hinoki et al.   HYPERTENSION

Ran on tracks - cytoplasmic roles for a nuclear regulator

(2009) D. Yudin et al.   JOURNAL OF CELL SCIENCE

Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown

(2009) Y. Baumer et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cdc42 is an antihypertrophic molecular switch in the mouse heart

(2009) Marjorie Maillet et al.   JOURNAL OF CLINICAL INVESTIGATION

The Rho/Rac exchange factor Vav2 controls nitric oxide–dependent responses in mouse vascular smooth muscle cells

(2009) Vincent Sauzeau et al.   JOURNAL OF CLINICAL INVESTIGATION

Raf-1: a novel cardiac troponin T kinase

(2009) Paul Pfleiderer et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation

(2009) Yanmei Tian et al.   MECHANISMS OF DEVELOPMENT

Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP

(2009) Anna A. Birukova et al.   MICROVASCULAR RESEARCH

Ras/MAPK signaling from endomembranes

(2009) Nicole Fehrenbacher et al.   Molecular Oncology

The Small GTPase Ral Couples the Angiotensin II Type 1 Receptor to the Activation of Phospholipase C- 1

(2009) C. M. Godin et al.   MOLECULAR PHARMACOLOGY

New susceptibility locus for coronary artery disease on chromosome 3q22.3

(2009) Jeanette Erdmann et al.   NATURE GENETICS

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RhoA-ROCK signaling is involved in contraction-mediated inhibition of SERCA2a expression in cardiomyocytes

(2009) Ronald Vlasblom et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of Smooth Muscle Contraction by Small GTPases

(2009) Sandra Puetz et al.   PHYSIOLOGY

Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

(2009) Amir Aghajanian et al.   PLoS One

Erk1 and Erk2 Regulate Endothelial Cell Proliferation and Migration during Mouse Embryonic Angiogenesis

(2009) Ruchika Srinivasan et al.   PLoS One

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

(2009) T. Araki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cardiac excitation and contraction by p21 activated kinase-1

(2009) Yunbo Ke et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

(2009) C. M. L. Beckers et al.   THROMBOSIS AND HAEMOSTASIS

Regulation of Myosin Light Chain Kinase Expression by Angiotensin II in Hypertension

(2008) Y.-J. Han et al.   AMERICAN JOURNAL OF HYPERTENSION

Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis

(2008) G. P. van Nieuw Amerongen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes

(2008) Katherine A. Sheehan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery

(2008) R. H. Adamson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction

(2008) Arintaya Phrommintikul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Critical role of Cdc42 in mediating endothelial barrier protection in vivo

(2008) Ramaswamy Ramchandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HDL-Associated Lysosphingolipids Inhibit NAD(P)H Oxidase-Dependent Monocyte Chemoattractant Protein-1 Production

(2008) Markus Tölle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors

(2008) Willem-Jan Pannekoek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells

(2008) M. Ernkvist et al.   BLOOD

Rho GTPase, Rac1, regulates Skp2 levels, vascular smooth muscle cell proliferation, and intima formation in vitro and in vivo

(2008) Mark Bond et al.   CARDIOVASCULAR RESEARCH

Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways

(2008) Maria I. Kontaridis et al.   CIRCULATION

Evidence for Statin Pleiotropy in Humans

(2008) Ping-Yen Liu et al.   CIRCULATION

Regulation of Endothelial Nitric Oxide Synthase and Postnatal Angiogenesis by Rac1

(2008) Naoki Sawada et al.   CIRCULATION RESEARCH

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

(2008) Mélanie Métrich et al.   CIRCULATION RESEARCH

H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors

(2008) Doinita Serban et al.   CIRCULATION RESEARCH

Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo

(2008) Maija K. Garnaas et al.   CIRCULATION RESEARCH

Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation

(2008) Juan Zhang et al.   CLINICA CHIMICA ACTA

Rho exchange factors in the cardiovascular system

(2008) G LOIRAND et al.   CURRENT OPINION IN PHARMACOLOGY

Are ECG abnormalities in Noonan syndrome characteristic for the syndrome?

(2008) R. Raaijmakers et al.   EUROPEAN JOURNAL OF PEDIATRICS

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR−/− mice

(2008) Hong-Wei Wang et al.   FASEB JOURNAL

Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac

(2008) Balakrishnan Selvakumar et al.   FEBS LETTERS

Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway

(2008) E. A. Lasater et al.   HUMAN MOLECULAR GENETICS

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

(2008) Yoko Aoki et al.   HUMAN MUTATION

A Major Haplotype Block at the Rho-Associated Kinase 2 Locus Is Associated with a Lower Risk of Hypertension in a Recessive Manner: The HYPGENE Study

(2008) Tuomo RANKINEN et al.   HYPERTENSION RESEARCH

Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection

(2008) Dominic P. Del Re et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiplex Kinase Signaling Modifies Cardiac Function at the Level of Sarcomeric Proteins

(2008) R. John Solaro   JOURNAL OF BIOLOGICAL CHEMISTRY

Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

(2008) Emily A. Oestreich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics

(2008) S. D. Smith et al.   JOURNAL OF CELL SCIENCE

Regulation of Kir2.1 channels by the Rho-GTPase, Rac1

(2008) Stephanie B. Boyer et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

(2008) Kensuke Noma et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

(2008) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Prevalent role of Akt and ERK activation in cardioprotective effect of Ca2+ channel- and beta-adrenergic receptor blockers

(2008) Krisztina Kovacs et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Rap1a Is a Key Regulator of Fibroblast Growth Factor 2-Induced Angiogenesis and Together with Rap1b Controls Human Endothelial Cell Functions

(2008) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leopard syndrome

(2008) Anna Sarkozy et al.   Orphanet Journal of Rare Diseases

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS

K-ras/PI3K-Akt Signaling Is Essential for Zebrafish Hematopoiesis and Angiogenesis

(2008) Lihui Liu et al.   PLoS One

Epidermal growth factor stimulates Rac1 and p21-activated kinase in vascular smooth muscle cells

(2007) Imke Beier et al.   ATHEROSCLEROSIS

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING

Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection

(2007) Anna A. Birukova et al.   JOURNAL OF CELLULAR PHYSIOLOGY