ARF family G proteins and their regulators: roles in membrane transport, development and disease

Decoupling of Activation and Effector Binding Underlies ARF6 Priming of Fast Endocytic Recycling

(2011) Guillaume Montagnac et al.   CURRENT BIOLOGY

Arfaptins Are Localized to thetrans-Golgi by Interaction with Arl1, but Not Arfs

(2011) Zhiqiu Man et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBC1D24, an ARF6-Interacting Protein, Is Mutated in Familial Infantile Myoclonic Epilepsy

(2010) Antonio Falace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

(2010) Maxence V. Nachury et al.   Annual Review of Cell and Developmental Biology

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice

(2010) Prashanthi Menon et al.   BRAIN RESEARCH

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism

(2010) Shehab A. Ismail et al.   CELL

RETRACTED: Cytohesins Are Cytoplasmic ErbB Receptor Activators

(2010) Anke Bill et al.   CELL

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Poliovirus replication requires the N-terminus but not the catalytic Sec7 domain of ArfGEF GBF1

(2010) George A. Belov et al.   CELLULAR MICROBIOLOGY

The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling

(2010) J. Lim et al.   GENES & DEVELOPMENT

The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

(2010) R. Jane Evans et al.   HUMAN MOLECULAR GENETICS

Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling

(2010) Cheryl J. Wiens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Calcium-dependent Activator Protein for Secretion 1 (CAPS1) with the Class II ADP-ribosylation Factor Small GTPases Is Required for Dense-core Vesicle Trafficking in thetrans-Golgi Network

(2010) Tetsushi Sadakata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Studies of the Arf Activator Arno on Model Membranes in the Presence of Arf Effectors Suggest Control by a Positive Feedback Loop

(2010) Danièle Stalder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

(2010) Yujie Li et al.   JOURNAL OF CELL BIOLOGY

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport inCaenorhabditis elegans

(2010) Sebiha Cevik et al.   JOURNAL OF CELL BIOLOGY

Cdc42 localization and cell polarity depend on membrane traffic

(2010) Naël Osmani et al.   JOURNAL OF CELL BIOLOGY

Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p

(2010) K.-Y. Chen et al.   JOURNAL OF CELL SCIENCE

The phosphatidylinositol 4-kinase PI4KIII  is required for the recruitment of GBF1 to Golgi membranes

(2010) K. Dumaresq-Doiron et al.   JOURNAL OF CELL SCIENCE

The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei

(2010) Helen P. Price et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The Arf-like GTPase Arl8 Mediates Delivery of Endocytosed Macromolecules to Lysosomes in Caenorhabditis elegans

(2010) Isei Nakae et al.   MOLECULAR BIOLOGY OF THE CELL

Arf3 Is Activated Uniquely at the trans-Golgi Network by Brefeldin A-inhibited Guanine Nucleotide Exchange Factors

(2010) Florin Manolea et al.   MOLECULAR BIOLOGY OF THE CELL

ADP Ribosylation Factors 1 and 4 and Group VIA Phospholipase A2 Regulate Morphology and Intraorganellar Traffic in the Endoplasmic Reticulum–Golgi Intermediate Compartment

(2010) Houchaima Ben-Tekaya et al.   MOLECULAR BIOLOGY OF THE CELL

Unregulated ARF6 Activation in Epithelial Cysts Generates Hyperactive Signaling Endosomes and Disrupts Morphogenesis

(2010) Jogender S. Tushir et al.   MOLECULAR BIOLOGY OF THE CELL

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

(2010) Andrey S. Selyunin et al.   NATURE

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

(2010) Julie A. Frearson et al.   NATURE

Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex

(2010) Sean M. O'Rourke et al.   NATURE CELL BIOLOGY

Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability

(2010) Cheryl Shoubridge et al.   NATURE GENETICS

An Arf-like Small G Protein, ARL-8, Promotes the Axonal Transport of Presynaptic Cargoes by Suppressing Vesicle Aggregation

(2010) Matthew P. Klassen et al.   NEURON

AMPA Receptor Signaling through BRAG2 and Arf6 Critical for Long-Term Synaptic Depression

(2010) Ralf Scholz et al.   NEURON

AGD5 is a GTPase-activating protein at the trans-Golgi network

(2010) Giovanni Stefano et al.   PLANT JOURNAL

Specific Functions of BIG1 and BIG2 in Endomembrane Organization

(2010) Frédéric Boal et al.   PLoS One

ADP-ribosylation factor machinery mediates endocytosis in plant cells

(2010) S. Naramoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a Structural Understanding of Arf Family:Effector Specificity

(2010) Philippe Chavrier et al.   STRUCTURE

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells

(2009) T. Quast et al.   BLOOD

ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in Cytokinesis

(2009) Guillaume Montagnac et al.   CURRENT BIOLOGY

Fluorescence Imaging-Based Screen Identifies ARF GEF Component of Early Endosomal Trafficking

(2009) Hirokazu Tanaka et al.   CURRENT BIOLOGY

Regulation of membrane trafficking and organ separation by the NEVERSHED ARF-GAP protein

(2009) S. J. Liljegren et al.   DEVELOPMENT

Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

(2009) Jana Mazelova et al.   EMBO JOURNAL

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

(2009) Tatiana Isabet et al.   EMBO JOURNAL

Role of the GNOM gene in Arabidopsis apical-basal patterning – From mutant phenotype to cellular mechanism of protein action

(2009) Sandra Richter et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The COPI system: Molecular mechanisms and function

(2009) R. Beck et al.   FEBS LETTERS

Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling

(2009) A. Hajdo-Milasinovic et al.   JOURNAL OF CELL SCIENCE

Coatomer-dependent protein delivery to lipid droplets

(2009) K. G. Soni et al.   JOURNAL OF CELL SCIENCE

Identification of GBF1 as a Cellular Factor Required for Hepatitis C Virus RNA Replication

(2009) L. Goueslain et al.   JOURNAL OF VIROLOGY

GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication

(2009) K. H. W. Lanke et al.   JOURNAL OF VIROLOGY

The ARF-Like GTPase ARFRP1 Is Essential for Lipid Droplet Growth and Is Involved in the Regulation of Lipolysis

(2009) A. Hommel et al.   MOLECULAR AND CELLULAR BIOLOGY

GRASP and IPCEF Promote ARF-to-Rac Signaling and Cell Migration by Coordinating the Association of ARNO/cytohesin 2 with Dock180

(2009) David T. White et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of a Golgi flippase by phosphoinositides and an ArfGEF

(2009) Paramasivam Natarajan et al.   NATURE CELL BIOLOGY

Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

(2009) Christopher A. Jones et al.   NATURE CELL BIOLOGY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impaired fear response in mice lacking GIT1

(2009) Robert Schmalzigaug et al.   NEUROSCIENCE LETTERS

Analysis of Endocytic Pathways in Drosophila Cells Reveals a Conserved Role for GBF1 in Internalization via GEECs

(2009) Gagan D. Gupta et al.   PLoS One

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity

(2009) E. Puxeddu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts

(2009) T. Heckel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

(2009) J. Ikenouchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis†

(2009) Hisataka Sabe et al.   TRAFFIC

Discovery of New Cargo Proteins that Enter Cells through Clathrin-Independent Endocytosis

(2009) Craig A. Eyster et al.   TRAFFIC

The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis

(2008) Sami M. Bahri et al.   DEVELOPMENTAL BIOLOGY

Aspergillus nidulansArfB Plays a Role in Endocytosis and Polarized Growth

(2008) Soo Chan Lee et al.   EUKARYOTIC CELL

Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia

(2008) Russell J. Ferland et al.   HUMAN MOLECULAR GENETICS

Autoinhibition of Arf GTPase-activating Protein Activity by the BAR Domain in ASAP1

(2008) Xiaoying Jian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consensus nomenclature for the human ArfGAP domain-containing proteins

(2008) Richard A. Kahn et al.   JOURNAL OF CELL BIOLOGY

Arf GTPase-activating Protein ASAP1 Interacts with Rab11 Effector FIP3 and Regulates Pericentrosomal Localization of Transferrin Receptor–positive Recycling Endosome

(2008) Hiroki Inoue et al.   MOLECULAR BIOLOGY OF THE CELL

Characterization of Class I and II ADP-Ribosylation Factors (Arfs) in Live Cells: GDP-bound Class II Arfs Associate with the ER-Golgi Intermediate Compartment Independently of GBF1

(2008) Justin Chun et al.   MOLECULAR BIOLOGY OF THE CELL

Redundant Roles of BIG2 and BIG1, Guanine-Nucleotide Exchange Factors for ADP-Ribosylation Factors in Membrane Traffic between the trans-Golgi Network and Endosomes

(2008) Ray Ishizaki et al.   MOLECULAR BIOLOGY OF THE CELL

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3

(2008) Stefan Veltel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correct Targeting of Plant ARF GTPases Relies on Distinct Protein Domains

(2008) Loren A. Matheson et al.   TRAFFIC

Yeast Arf3p Modulates Plasma Membrane PtdIns(4,5)P2 Levels to Facilitate Endocytosis

(2008) Iwona I. Smaczynska-de Rooij et al.   TRAFFIC

Differential Membrane Association Properties and Regulation of Class I and Class II Arfs

(2008) Daniël Duijsings et al.   TRAFFIC

COPI Complex Is a Regulator of Lipid Homeostasis

(2008) Mathias Beller et al.   PLOS BIOLOGY

A Critical Role of a Cellular Membrane Traffic Protein in Poliovirus RNA Replication

(2008) George A. Belov et al.   PLoS Pathogens

Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation

(2008) Monique H. Verheije et al.   PLoS Pathogens

Substrate specificities and activities of AZAP family Arf GAPs in vivo

(2007) Ellen J. Cuthbert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ADP-ribosylation factor arf6p may function as a molecular switch of new end take off in fission yeast

(2007) Atsushi Fujita   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fbx8 Makes Arf6 Refractory to Function via Ubiquitination

(2007) Hajime Yano et al.   MOLECULAR BIOLOGY OF THE CELL