Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria

(2017) Ganesh Krishnamoorthy et al.   mBio

Delafloxacin: design, development and potential place in therapy

(2017) Francico Javier Candel et al.   Drug Design Development and Therapy

Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD

(2017) Ramkumar Iyer et al.   ACS Infectious Diseases

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

(2017) Jonathan M. Stokes et al.   Nature Microbiology

Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

(2017) Muriel Masi et al.   Nature Microbiology

Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane

(2017) Laura Chiaradia et al.   Scientific Reports

Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides

(2016) Nermina Malanovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Gestalt approach to Gram-negative entry

(2016) Lynn L. Silver   BIOORGANIC & MEDICINAL CHEMISTRY

Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials

(2016) Sara Hernando-Amado et al.   DRUG RESISTANCE UPDATES

Multidrug efflux pumps of Gram-positive bacteria

(2016) Bryan D. Schindler et al.   DRUG RESISTANCE UPDATES

Targeting human pathogenic bacteria by siderophores: A proteomics review

(2016) Daniela Ferreira et al.   Journal of Proteomics

Surface-Exposed Lipoproteins: An Emerging Secretion Phenomenon in Gram-Negative Bacteria

(2016) Marlena M. Wilson et al.   TRENDS IN MICROBIOLOGY

Are the physicochemical properties of antibacterial compounds really different from other drugs?

(2016) Jean-Paul Ebejer et al.   Journal of Cheminformatics

Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent Successes

(2015) Jamie Parkin et al.   BIOPHYSICAL JOURNAL

Nanotechnology approaches for antibacterial drug delivery: Preparation and microbiological evaluation of fusogenic liposomes carrying fusidic acid

(2015) Daria Nicolosi et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria

(2014) Tony D. Davis et al.   ACS Chemical Biology

Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations

(2014) Jingjing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nanocarriers for antibiotics: A promising solution to treat intracellular bacterial infections

(2014) Nadia Abed et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Which Three-Dimensional Characteristics Make Efficient Inhibitors of Protein–Protein Interactions?

(2014) Mélaine A. Kuenemann et al.   Journal of Chemical Information and Modeling

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

(2014) Ritu Bansal-Mutalik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mycobacterial Cell Envelope--Lipids

(2014) M. Jackson   Cold Spring Harbor Perspectives in Medicine

Siderophores as “Trojan Horses”: tackling multidrug resistance?

(2014) Carla C. C. R. de Carvalho et al.   Frontiers in Microbiology

A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

(2014) Gregory S. Bisacchi et al.   ACS Infectious Diseases

Siderophore conjugates

(2013) Malcolm G. P. Page   Annals of the New York Academy of Sciences

Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins

(2013) Stefania Galdiero et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

The intrinsic resistome of bacterial pathogens

(2013) Jorge Olivares et al.   Frontiers in Microbiology

Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers

(2012) Cheng Ji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

(2012) John I. Manchester et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs

(2012) Miguel Viveiros et al.   Expert Review of Anti-Infective Therapy

Microbial siderophores: a mini review

(2012) Ratul Saha et al.   JOURNAL OF BASIC MICROBIOLOGY

Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery

(2012) John I. Manchester et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily

(2011) Babajide O. Okandeji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of theS. aureusNorA Efflux Pump

(2011) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli

(2010) M. G. P. Page et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Siderophore uptake in bacteria and the battle for iron with the host; a bird’s eye view

(2010) Byron C. Chu et al.   BIOMETALS

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Influence of efflux pump inhibitors on the multidrug resistance ofHelicobacter pylori

(2010) Zhan Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth

(2009) S. Ramon-Garcia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis of citrate–ciprofloxacin conjugates

(2009) Siti R Md-Saleh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Wall Teichoic Acid Function, Biosynthesis, and Inhibition

(2009) Jonathan G. Swoboda et al.   CHEMBIOCHEM

Efflux-Mediated Drug Resistance in Bacteria

(2009) Xian-Zhi Li et al.   DRUGS

The wall teichoic acid and lipoteichoic acid polymers of Staphylococcus aureus

(2009) Guoqing Xia et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Liposomes as delivery systems for antibiotics

(2009) Zuzanna Drulis-Kawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State

(2008) B. Zuber et al.   JOURNAL OF BACTERIOLOGY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY

Cell wall peptidoglycan architecture in Bacillus subtilis

(2008) E. J. Hayhurst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA