Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

Biochemistry and biomedicine of quantum dots: from biodetection to bioimaging, drug discovery, diagnostics, and therapy

(2018) Jun Yao et al.   Acta Biomaterialia

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

(2018) Anke C. Schiedel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dysfunction of various organelles provokes multiple cell death after quantum dot exposure

(2018) Yan Wang et al.   International Journal of Nanomedicine

Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

(2018) Qingwen Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors

(2018) Jesica G. Mild et al.   MOLECULAR BIOTECHNOLOGY

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors

(2018) Madhu Chaturvedi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells

(2018) Leigh A. Stoddart et al.   Scientific Reports

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins

(2018) Estefanía Moreno et al.   Frontiers in Pharmacology

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

(2018) Shoji Maeda et al.   Nature Communications

Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial

(2017) Stewart Tepper et al.   LANCET NEUROLOGY

An update on the physiological and therapeutic relevance of GPCR oligomers

(2017) Batoul Farran   PHARMACOLOGICAL RESEARCH

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

(2017) Pauline Scholler et al.   Nature Communications

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure

(2017) James H. Felce et al.   Cell Reports

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

(2017) David Moreno Delgado et al.   eLife

General Bioluminescence Resonance Energy Transfer Homogeneous Immunoassay for Small Molecules Based on Quantum Dots

(2016) Xuezhi Yu et al.   ANALYTICAL CHEMISTRY

Multiplex detection of protein–protein interactions using a next generation luciferase reporter

(2016) Lisette G.G.C. Verhoef et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence

(2016) Christopher G. England et al.   BIOCONJUGATE CHEMISTRY

Quantum dot–NanoLuc bioluminescence resonance energy transfer enables tumor imaging and lymph node mapping in vivo

(2016) Anyanee Kamkaew et al.   CHEMICAL COMMUNICATIONS

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets

(2016) Tengfei Li et al.   JOURNAL OF CONTROLLED RELEASE

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

(2016) Alem W Kahsai et al.   Nature Chemical Biology

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

Physical interaction between neurofibromin and serotonin 5-HT6receptor promotes receptor constitutive activity

(2016) Wissem Deraredj Nadim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions

(2015) Thomas Machleidt et al.   ACS Chemical Biology

Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding

(2015) Leigh A Stoddart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Application of BRET to monitor ligand binding to GPCRs

(2015) Leigh A Stoddart et al.   NATURE METHODS

Clinical Application of Anti-CCR4 Monoclonal Antibody

(2015) Ryuzo Ueda   ONCOLOGY

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

BRET evidence that β2 adrenergic receptors do not oligomerize in cells

(2015) Tien-Hung Lan et al.   Scientific Reports

Targeting thecis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

(2014) L Cobret et al.   BRITISH JOURNAL OF PHARMACOLOGY

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Strategies for Small Molecule Library Design

(2014) David Sheppard et al.   CURRENT PHARMACEUTICAL DESIGN

Application of BRET for Studying G Protein-Coupled Receptors

(2014) Agnieszka Kaczor et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth

(2014) Fanny Duhr et al.   Nature Chemical Biology

How proteins bind macrocycles

(2014) Elizabeth A Villar et al.   Nature Chemical Biology

Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

(2014) Jonathan W. Kotula et al.   PLoS One

Improved Methodical Approach for Quantitative BRET Analysis of G Protein Coupled Receptor Dimerization

(2014) Bence Szalai et al.   PLoS One

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growthin Vivo

(2013) David Maussang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel multistep BRET-FRET energy transfer using nanoconjugates of firefly proteins, quantum dots, and red fluorescent proteins

(2013) Rabeka Alam et al.   Nanoscale

Use of hGluc/tdTomato pair for sensitive BRET sensing of protease with high solution media tolerance

(2013) Fengyun Li et al.   TALANTA

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

Buffer enhanced bioluminescence resonance energy transfer sensor based on Gaussia luciferase for in vitro detection of protease

(2012) Fengyun Li et al.   ANALYTICA CHIMICA ACTA

Effect of enhanced Renilla luciferase and fluorescent protein variants on the Förster distance of Bioluminescence resonance energy transfer (BRET)

(2012) Helen Dacres et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

(2012) Tengfei Li et al.   FASEB JOURNAL

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

(2012) Katie O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designing Quantum Rods for Optimized Energy Transfer with Firefly Luciferase Enzymes

(2012) Rabeka Alam et al.   NANO LETTERS

Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging

(2012) Liqin Xiong et al.   Nature Communications

Setting Up a Bioluminescence Resonance Energy Transfer High throughput Screening Assay to Search for Protein/Protein Interaction Inhibitors in Mammalian Cells

(2012) Cyril Couturier et al.   Frontiers in Endocrinology

Structural Basis of M3Muscarinic Receptor Dimer/Oligomer Formation

(2011) Sara M. McMillin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects

(2011) A. Dragulescu-Andrasi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

(2010) George Khelashvili et al.   BIOINFORMATICS

Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle

(2010) Nobuyuki Kosaka et al.   Contrast Media & Molecular Imaging

Optimization of enzyme-substrate pairing for bioluminescence imaging of gene transfer using Renilla and Gaussia luciferases

(2010) Takahiro Kimura et al.   JOURNAL OF GENE MEDICINE

Disrupting 5-HT2A Receptor/PDZ Protein Interactions Reduces Hyperalgesia and Enhances SSRI Efficacy in Neuropathic Pain

(2010) Xavier Pichon et al.   MOLECULAR THERAPY

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Llama Single Domain Antibodies Specific for the 7 Botulinum Neurotoxin Serotypes as Heptaplex Immunoreagents

(2010) Jerry O. Conway et al.   PLoS One

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

(2010) S. Jahnichen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Improved donor/acceptor BRET couples for monitoring β-arrestin recruitment to G protein-coupled receptors

(2009) Maud Kamal et al.   Biotechnology Journal

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

(2009) Bettye Hollins et al.   CELLULAR SIGNALLING

Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization

(2009) Mohammed A Ayoub et al.   CURRENT OPINION IN PHARMACOLOGY

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

(2009) Patrick M. Sexton et al.   DRUG DISCOVERY TODAY

BRET3: a red-shifted bioluminescence resonance energy transfer (BRET)-based integrated platform for imaging protein-protein interactions from single live cells and living animals

(2009) Abhijit De et al.   FASEB JOURNAL

The BRET technology and its application to screening assays

(2008) Johan Bacart et al.   Biotechnology Journal

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS

Fluorescence-based methods in the study of protein–protein interactions in living cells

(2008) Francisco Ciruela   CURRENT OPINION IN BIOTECHNOLOGY

Interaction networks for systems biology

(2008) Samuel Bader et al.   FEBS LETTERS

Reviews in Molecular Biology and Biotechnology: Transmembrane Signaling by G Protein-Coupled Receptors

(2008) Louis M. Luttrell   MOLECULAR BIOTECHNOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Therapeutic Modalities to Address Nondrugable Protein Interaction Targets

(2008) Errol B De Souza et al.   NEUROPSYCHOPHARMACOLOGY

Protein–protein interaction and quaternary structure

(2008) Joël Janin et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

G-protein-coupled receptor heteromers: function and ligand pharmacology

(2007) R Franco et al.   BRITISH JOURNAL OF PHARMACOLOGY

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization

(2007) G Milligan   BRITISH JOURNAL OF PHARMACOLOGY