ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review

(2018) Dona M. P. Jayakody et al.   Frontiers in Neuroscience

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired autophagic flux and p62-mediated EMT are involved in arsenite-induced transformation of L-02 cells

(2017) Xinlu Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy

(2016) Nesrine Benkafadar et al.   EMBO Molecular Medicine

Effect of testosterone on the regulation of p53 and p66Shc during oxidative stress damage in C2C12 cells

(2016) Lucía Pronsato et al.   STEROIDS

Is senescence-associated β-galactosidase a marker of neuronal senescence?

(2016) Malgorzata Piechota et al.   Oncotarget

Autophagy Attenuates Noise-Induced Hearing Loss by Reducing Oxidative Stress

(2015) Hu Yuan et al.   ANTIOXIDANTS & REDOX SIGNALING

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Age-regulated function of autophagy in the mouse inner ear

(2015) Rocío de Iriarte Rodríguez et al.   HEARING RESEARCH

Rapamycin alleviates cisplatin-induced ototoxicity in vivo

(2014) Bin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity

(2014) Marjo-Riitta Puumalainen et al.   Nature Communications

Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

(2013) Kazutetsu Aoshiba et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases

(2013) Anil K. Mantha et al.   MITOCHONDRION

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues

(2012) Rosalind A. Rosenthal et al.   Anti-Cancer Agents in Medicinal Chemistry

Assessing Cell and Organ Senescence Biomarkers

(2012) Bruno Bernardes de Jesus et al.   CIRCULATION RESEARCH

A Synthetic Superoxide Dismutase/Catalase Mimetic EUK-207 Mitigates Radiation Dermatitis and Promotes Wound Healing in Irradiated Rat Skin

(2012) Susan R. Doctrow et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mouse models of age-related mitochondrial neurosensory hearing loss

(2012) Chul Han et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Correlation between plasma levels of radical scavengers and hearing threshold among elderly subjects with age-related hearing loss

(2011) Akeem Olawale Lasisi et al.   ACTA OTO-LARYNGOLOGICA

Oxidative Stress, Inflammation, and Autophagic Stress as the Key Mechanisms of Premature Age-Related Hearing Loss in SAMP8 Mouse Cochlea

(2011) Julien Menardo et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization

(2011) Raffaella Di Micco et al.   CELL CYCLE

Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

(2011) Marc Liesa et al.   CIRCULATION

Activation of Lipopolysaccharide-TLR4 Signaling Accelerates the Ototoxic Potential of Cisplatin in Mice

(2010) G.-S. Oh et al.   JOURNAL OF IMMUNOLOGY

Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues

(2009) M. Lebiedzinska et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regional distribution of manganese superoxide dismutase 2 (Mn SOD2) expression in rodent and primate spiral ganglion cells

(2009) Yu-Lan Mary Ying et al.   HEARING RESEARCH

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

(2009) S. Someya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice

(2008) Aaron Clausen et al.   NEUROBIOLOGY OF AGING