Article
Nutrition & Dietetics
Laura Sinisterra-Loaiza, Patricia Alonso-Lovera, Alejandra Cardelle-Cobas, Jose Manuel Miranda, Beatriz I. Vazquez, Alberto Cepeda
Summary: Various studies have found that specific groups or dietary compounds play a role in the onset and progression of obesity, and gut microbiota serves as a mediator between these compounds and the associated inflammation. This study aimed to evaluate the dietary intake of overweight, obese, and normal-weight individuals and analyze their gut microbiota profile in relation to changes in Body Mass Index (BMI) and diet. The results showed significant differences in fiber and monounsaturated fatty acids (MUFAs) intake among different BMI groups, with better intake adequacy observed in the normal-weight group. The analysis of gut microbiota revealed distinct microbial composition in overweight and obese individuals compared to normal-weight individuals, with specific genera identified as biomarkers for each group.
Article
Agriculture, Multidisciplinary
Shufen Han, Hui Gao, Ruijuan Song, Weiguo Zhang, Yuezhen Li, Jie Zhang
Summary: Oat fiber can prevent obesity and dyslipidemia caused by a high-fat diet by restoring circadian oscillations; High-fat diet disrupts the hepatic circadian protein expressions, while oat fiber reverses these effects; SCFAs play a crucial role in regulating circadian rhythm and mediating the beneficial effects of oat fiber.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Maria Juarez-Fernandez, Sara Roman-Saguillo, David Porras, Maria Victoria Garcia-Mediavilla, Pedro Linares, Maria Dolores Ballesteros-Pomar, Ana Urioste-Fondo, Begona Alvarez-Cuenllas, Javier Gonzalez-Gallego, Sonia Sanchez-Campos, Francisco Jorquera, Esther Nistal
Summary: Bariatric surgery can improve the health status of obese patients, significantly impact gut microbiota composition, and be associated with specific metabolome profiles. The study suggests that bariatric surgery has long-term positive effects on the remission of obesity.
Review
Food Science & Technology
Bingbing Guo, Jingyi Zhang, Weihao Zhang, Feng Chen, Bin Liu
Summary: This comprehensive review explores the production of short chain fatty acids (SCFAs) by gut microbiota, their transportation through the gut-brain axis, and the potential mechanisms by which they influence age-related neurodegenerative disorders. The review also discusses the importance of dietary fiber sources and the challenges associated with harnessing dietary-derived SCFAs as promoters of neurological health in elderly individuals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jing Guo, Mengyuan Zhang, He Wang, Na Li, Zongliang Lu, Long Li, Suocheng Hui, Hongxia Xu
Summary: Mounting evidence suggests a link between obesity, metabolic disorders, and dysbiosis of the gut microbiota. Dietary inulin has shown potential in modulating this dysbiosis and improving glucose and lipid metabolism disorders. However, the underlying mechanisms remain unclear. This study investigated the effects of dietary inulin on metabolic homeostasis in obese ob/ob mice. The results demonstrate that inulin-induced remodeling of the gut microbiota increased production of short chain fatty acids (SCFAs) and enhanced expression of angiopoietin-like protein 4 (ANGPTL4), resulting in improved glucose and lipid metabolism. These findings suggest that the gut microbiota, SCFAs, and the ANGPTL4 pathway may partially mediate the beneficial effects of inulin on metabolic disorders.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Longying Pei, Wei Liu, Luping Liu, Xiaoyu Wang, Luxi Jiang, Zhaohui Chen, Qiquan Wang, Peng Wang, Heng Xu
Summary: This study investigated the effects of morel mushroom supplementation on the gut bacterial microbiota and short-chain fatty acids in healthy mice. The results showed that morel intervention altered the bacterial community composition, increased short-chain fatty acids levels, and was associated with weight loss. These findings contribute to the development of prebiotics for improving health and reducing obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Xincheng Wu, Xiaojun Huang, Wanning Ma, Mingzhi Li, Jiajia Wen, Chunhua Chen, Liandi Liu, Shaoping Nie
Summary: This study compared the intestinal immunomodulatory mechanisms of nine representative bioactive polysaccharides. The results revealed that these polysaccharides promote intestinal immunity through different ways, such as alleviating immune suppression in intestinal mucosal T cells, improving the intestinal microenvironment, promoting the colonization of beneficial bacteria, inhibiting the colonization of harmful bacteria, and alleviating the accumulation of certain metabolites in the large intestine. These findings provide a guideline for the development of superior intestinal immunomodulatory polysaccharides.
Review
Biochemistry & Molecular Biology
Anzhu Wang, Zhendong Li, Zhuo Sun, Dawu Zhang, Xiaochang Ma
Summary: Heart failure is a complex clinical syndrome with high morbidity and mortality, and it poses a significant global health burden. Inflammation and metabolic disorders are closely associated with the development of heart failure, which depends on the severity and type of heart failure, as well as common metabolic comorbidities such as obesity and diabetes. Short-chain fatty acids (SCFAs) play an important role in regulating cardiac function and have unique effects on systemic immunity and metabolism. This review highlights the role of SCFAs in connecting metabolism and immunity, and how they improve cardiac efficiency, alleviate cardiac inflammation, and enhance cardiac function in failing hearts. SCFAs represent a promising new therapeutic approach for heart failure.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Karley K. Mahalak, Jamshed Bobokalonov, Jenni Firrman, Russell Williams, Bradley Evans, Brian Fanelli, Jason W. Soares, Masuko Kobori, LinShu Liu
Summary: In this study, we found that regular consumption of capsaicin can change the structure of the gut microbial community and increase the abundance of certain short-chain fatty acids, particularly butanoic acid. These changes may be responsible for the health benefits associated with capsaicin consumption.
Review
Gastroenterology & Hepatology
Ana Nogal, Ana M. Valdes, Cristina Menni
Summary: Diet plays a crucial role in modulating gut microbiota composition and function, affecting the production of SCFAs which have beneficial effects on cardio-metabolic health. Targeting the gut microbiota through dietary strategies to increase SCFA production may be beneficial in improving cardio-metabolic outcomes.
Review
Nutrition & Dietetics
Peng Zhao, Suhong Zhao, Jinwei Tian, Xinxin Liu
Summary: This review primarily focuses on the relationship between the gut microbiota and its major metabolites, such as short-chain fatty acids (SCFAs), and heart failure (HF), aiming to explore effective treatments for HF by targeting SCFAs and improve patients' quality of life.
Article
Biochemistry & Molecular Biology
Xiaodan Lu, Rongbin Zhong, Ling Hu, Luyao Huang, Lijiao Chen, Wenjian Cheng, Baodong Zheng, Peng Liang
Summary: The study revealed that LYCRPLs significantly regulate lipid metabolism and improve gut microbiota disorder induced by a high-fat diet in rats.
Review
Geriatrics & Gerontology
Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. They play a role in various physiological and pathological processes in the human body, including potential roles and mechanisms in neurodegenerative diseases such as Alzheimer's disease.
Article
Environmental Sciences
Hongli Liu, Yixiu Bai, Yingying Yu, Zenghua Qi, Guoxia Zhang, Guiying Li, Yingxin Yu, Taicheng An
Summary: By orally exposing female Sprague Dawley rats to Resorcinol-bis(diphenyl)-phosphate (RDP) during pregnancy and lactation, it was found that RDP accumulated in the livers of maternal rats and offspring, and its level increased with exposure time. The exposure to RDP also disrupted the gut microbiota homeostasis and altered gut microbiome-related metabolism. These findings suggest that RDP has significant adverse effects on gut microbiota and metabolic function, which may increase the long-term risks of inflammation, obesity, and metabolic diseases.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Microbiology
Craig Resch, Mihir Parikh, J. Alejandro Austria, Spencer D. Proctor, Thomas Netticadan, Heather Blewett, Grant N. Pierce
Summary: Research indicates that an HFHS diet leads to dysbiosis in the gut microbiota, and gender, diet, and flaxseed supplementation all play a role in influencing the composition and diversity of the microbiota.
Editorial Material
Gastroenterology & Hepatology
Raylene A. Reimer, Nathalie M. Delzenne
Article
Nutrition & Dietetics
Faye Chleilat, Alana Schick, Raylene A. Reimer
Summary: Paternal prebiotic intake affects energy intake and serum PYY levels in fathers, as well as hepatic triglycerides and gut microbiota composition in offspring, with a more pronounced effect seen in female offspring.
Article
Nutrition & Dietetics
Dana E. Lowry, Heather A. Paul, Raylene A. Reimer
Summary: The composition of breast milk in rats can be influenced by maternal consumption of a high-fat/sucrose diet and prebiotic supplementation, leading to changes in protein and miRNA levels. These components in milk may partially explain the impact of maternal diets on offspring body composition. Furthermore, the correlations between milk components, offspring body composition, and gut microbiota can vary by sex, indicating a complex interplay of factors.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Pediatrics
Teja Klancic, Amanda M. Black, Raylene A. Reimer
Summary: The study found a potential association between maternal exposure to antibiotics during birth and increased infant BMI z scores at 1 year of age, although this association was no longer significant after adjusting for confounding factors.
Article
Public, Environmental & Occupational Health
A. Justine Dowd, Liam Kronlund, Cassandra Warbeck, Candice Parmar, Julia T. Daun, Kathryn Wytsma-Fisher, Raylene A. Reimer, Guillaume Millet, Tak Fung, S. Nicole Culos-Reed
Summary: The pilot MOVE-C study showed that a 12-week HIIT plus lifestyle education program can significantly improve quality of life, exercise behavior, gastrointestinal symptoms, and self-compassion among inactive adults with coeliac disease. This intervention also resulted in significant improvements in adherence to a gluten-free diet for all participants.
PSYCHOLOGY & HEALTH
(2022)
Article
Nutrition & Dietetics
Weilan Wang, Chunlong Mu, Nicole A. Cho, Erin W. Noye Tuplin, Dana E. Lowry, Faye Chleilat, Kate M. Sales, Kara Sampsell, Jane Shearer, Raylene A. Reimer
Summary: Early life nutrition, particularly human milk oligosaccharides (HMO), has a crucial impact on neonatal development and health. However, supplementing rat milk substitutes with 2'-FL and/or 3'-SL did not significantly affect the growth, body composition, and faecal microbiota of artificially reared rat pups, suggesting that further research on the protective effects of HMO in models of premature birth or malnutrition is warranted.
BRITISH JOURNAL OF NUTRITION
(2022)
Letter
Gastroenterology & Hepatology
Maitreyi Raman, Raylene A. Reimer, Subrata Ghosh, Jeff Vallance
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Psychiatry
Marcel van de Wouw, Yanan Wang, Matthew L. Workentine, Elnaz Vaghef-Mehrabani, Deborah Dewey, Raylene A. Reimer, Lianne Tomfohr-Madsen, Gerald F. Giesbrecht
Summary: The study found associations between gut microbiota and internalizing behaviors in preschool-aged children, with gut microbiota diversity negatively correlated with certain behavior subscales. Moreover, specific short-chain fatty acids were correlated with internalizing behaviors, suggesting potential for future interventions targeting SCFA production.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Clinical Neurology
Yanan Wang, Marcel van de Wouw, Lauren Drogos, Elnaz Vaghef-Mehrabani, Raylene A. Reimer, Lianne Tomfohr-Madsen, Gerald F. Giesbrecht
Summary: The study reveals a novel association between sleep and gut microbiota in preschool-aged children. Longer night-time sleep and greater sleep efficiency were associated with specific commensal bacteria that may regulate sleep through modulating neurotransmitter metabolism and the immune system. Additionally, fecal metabolites like tryptophan and propionate show associations with sleep parameters.
Article
Medicine, General & Internal
Chunlong Mu, Anamika Choudhary, Shyamchand Mayengbam, Karlene T. Barrett, Jong M. Rho, Jane Shearer, Morris H. Scantlebury
Summary: The study found that the combination of antibiotics and a ketogenic diet can reduce the occurrence of infantile spasms and improve the efficacy of the ketogenic diet. Examination of the gut microbiota and metabolomics showed downregulation of indoleamine 2,3-dioxygenase I and upregulation of hippocampal kynurenic acid, a metabolite with antiepileptic effects. Inhibitors of indoleamine 2,3-dioxygenase I and antibiotics that inhibit kynurenine formation were effective in reducing spasms and elevating hippocampal kynurenic acid. Additionally, a fecal microbiota transplant experiment demonstrated the important role of the gut microbiota in improving spasms.
Article
Nutrition & Dietetics
Weilan Wang, Jodi E. Nettleton, Michael G. Gaenzle, Raylene A. Reimer
Summary: Maternal consumption of non-nutritive sweeteners can alter the composition and metabolism of the cecal microbiome in offspring, which is associated with increased body weight and body fat. The changes in microbial composition and metabolism may be responsible for the increased obesity risk in offspring.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Erin W. Noye Tuplin, Erna Alukic, Dana E. Lowry, Faye Chleilat, Weilan Wang, Nicole A. Cho, Kara Sampsell, Kate M. Sales, Shyamchand Mayengbam, Kathy D. McCoy, Raylene A. Reimer
Summary: Dietary fiber promotes a healthy gut microbiome and can attenuate unfavorable microbial changes resulting from a high-fat/sucrose diet. Different types of fiber diets improve insulin sensitivity and cognitive function to varying degrees.
Article
Nutrition & Dietetics
Chunlong Mu, Angela Pochakom, Raylene A. Reimer, Anamika Choudhary, Melinda Wang, Jong M. Rho, Morris H. Scantlebury, Jane Shearer
Summary: The ketogenic diet is an effective treatment for infantile spasms syndrome. This study investigated the effect of adding a prebiotic fiber to the diet, and found that it improved metabolic parameters and gut microbiota diversity. However, it had no impact on spasms or developmental outcomes.
Article
Oncology
Kara Sampsell, Weilan Wang, Christina Ohland, Lukas F. Mager, Nicola Pett, Dana E. Lowry, Kate M. Sales, Margaret L. McNeely, Kathy D. McCoy, S. Nicole Culos-Reed, Raylene A. Reimer
Summary: Exercise and diet have beneficial effects on the gut microbiota of breast cancer patients, potentially reducing tumor volume and enhancing treatment outcomes through improved anti-tumor immune response.
Article
Oncology
Julie M. Deleemans, Faye Chleilat, Raylene A. Reimer, Mohamad Baydoun, Katherine-Ann Piedalue, Dana E. Lowry, Jan-Willem Henning, Linda E. Carlson
Summary: This study investigated the effects of chemotherapy on the gut microbiota, gastrointestinal symptoms, and psychosocial outcomes in cancer survivors. The results showed potential long-term dysbiosis in the gut microbiota of survivors, which may be associated with psychosocial symptoms.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)