AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model

The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis

(2018) Søren Møller et al.   LIVER INTERNATIONAL

The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

(2018) Philipp Schwabl et al.   Scientific Reports

Aicar treatment reduces interstitial fibrosis in aging mice

(2017) Katarzyna A. Cieslik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pathological process of liver sinusoidal endothelial cells in liver diseases

(2017) Yao Ni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Diagnosis of cirrhosis and portal hypertension: imaging, non-invasive markers of fibrosis and liver biopsy

(2017) Bogdan Procopet et al.   Gastroenterology Report

The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis

(2016) Daniel Karin et al.   DIFFERENTIATION

Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

(2016) Juan G. Abraldes et al.   GASTROENTEROLOGY

Clinical implications of basic research in hepatocellular carcinoma

(2016) Renumathy Dhanasekaran et al.   JOURNAL OF HEPATOLOGY

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

(2015) Y. Chen et al.   FREE RADICAL RESEARCH

Molecular pathophysiology of portal hypertension

(2015) Mercedes Fernandez   HEPATOLOGY

5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside alleviated carbon tetrachloride-induced acute hepatitis in mice

(2015) Changming Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling

(2015) Yongbin Yang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments

(2015) Jaume Bosch et al.   JOURNAL OF HEPATOLOGY

Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction

(2015) Jia Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nitric oxide in liver diseases

(2015) Yasuko Iwakiri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability

(2015) X Tong et al.   Cell Death & Disease

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

(2014) Ali A Mokdad et al.   BMC Medicine

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

(2014) Giusi Marrone et al.   GUT

Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice

(2014) Xia Cao et al.   HYPERTENSION RESEARCH

The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts

(2014) Kuan-Hsing Chen et al.   PLoS One

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Current concepts on the role of nitric oxide in portal hypertension

(2013) Liang Shuo Hu   WORLD JOURNAL OF GASTROENTEROLOGY

Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol

(2012) Thomas Reiberger et al.   GUT

Nitric Oxide: Considerations for the Treatment of Ischemic Stroke

(2012) Nicole A Terpolilli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

(2012) Sabine Klein et al.   JOURNAL OF HEPATOLOGY

AMP-Activated Protein Kinase Inhibits Homocysteine-Induced Dysfunction and Apoptosis in Endothelial Progenitor Cells

(2011) Fang Jia et al.   CARDIOVASCULAR DRUGS AND THERAPY

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

(2011) Ruchi Bansal et al.   HEPATOLOGY

Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice

(2011) M. M. van Beuge et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

(2011) Marike Marjolijn van Beuge et al.   PHARMACEUTICAL RESEARCH

Activation of AMP-Activated Protein Kinase by 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside in the Muscle Microcirculation Increases Nitric Oxide Synthesis and Microvascular Perfusion

(2010) Eloise A. Bradley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension

(2010) Erwin Biecker et al.   LIVER INTERNATIONAL

Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial

(2009) Juan G. Abraldes et al.   GASTROENTEROLOGY

Randomized controlled trial of carvedilol versus variceal band ligation for the prevention of the first variceal bleed

(2009) Dhiraj Tripathi et al.   HEPATOLOGY

Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans

(2009) Montserrat Moreno et al.   HEPATOLOGY

Possible mechanisms involved in the discrepancy of hepatic and aortic endothelial nitric oxide synthases during the development of cirrhosis in rats

(2009) Morvarid Shir Mohammadi et al.   LIVER INTERNATIONAL

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

(2008) Leonor Rivera et al.   BIOCHEMICAL PHARMACOLOGY

High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase

(2008) Masayuki Adachi et al.   HEPATOLOGY