Article
Dermatology
Teppei Hagino, Hajime Nakano, Hidehisa Saeki, Naoko Kanda
Summary: Darier's disease is a rare genetic skin disorder caused by mutations in the ATP2A2 gene. A case study presented a novel missense mutation in this gene and successful treatment with a two-compound ointment.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rizwan Qaisar, Gavin Pharaoh, Shylesh Bhaskaran, Hongyang Xu, Rojina Ranjit, Jan Bian, Bumsoo Ahn, Constantin Georgescu, Jonathan D. Wren, Holly Van Remmen
Summary: The study showed that pharmacological activation of SERCA can mitigate sarcopenia phenotype in aging mice, reversing reductions in muscle mass and force generation, and preventing an increase in mitochondrial ROS production. These effects are mediated in part by enhanced cellular energetics through activation of PGC1-alpha, UCP1, HSF1, and APMK, as well as increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhi Wang, Xu Zhang, Feng Zhu, Simin Zhou, Qiushu Wang, Hegui Wang
Summary: This study found that overexpression of AKAP5 can alleviate cardiomyocyte apoptosis induced by H/R, possibly by anchoring PICA to mediate the PLN/SERCA pathway. This provides evidence for AKAP5 as a potential therapeutic target for the prevention and treatment of ischemia-reperfusion injury.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Food Science & Technology
Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward
Summary: Endothelial dysfunction may lead to atherosclerosis, while dietary nitrate/nitrite shows significant benefits on cardiovascular homeostasis. Research suggests that nitrate/nitrite may enhance eNOS activation by stimulating AMPK signaling pathway, potentially contributing to vascular protective effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Sara Basse Hansen, Mateusz Dyla, Caroline Neumann, Esben Meldgaard Hoegh Quistgaard, Jacob Lauwring Andersen, Magnus Kjaergaard, Poul Nissen
Summary: The crystal structures of LMCA1 reveal its pre-organization for dephosphorylation upon calcium release in the E2P state, with an arginine side chain occupying a calcium binding site and suggesting a direct proton counter transport through calcium exchange pathways. This provides insight into the evolutionary divergence and conserved features of this important class of ion transporters.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Silvia Dragoni, Bruna Caridi, Eleni Karatsai, Thomas Burgoyne, Mosharraf H. Sarker, Patric Turowski
Summary: Neuronal and retinal disorders are often associated with pathological hyperpermeability of microvasculature. Using rodent retina explants, researchers studied acute neurovascular permeability and the role of AMP-activated protein kinase (AMPK). They found that AMPK plays a key role in regulating endothelial permeability through activation of eNOS and p38, providing a link between calcium transients and permeability regardless of the inducing factor.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Summary: Endothelial cells sense shear stress through Piezo1 and activate ER Ca2+ entry and release via IP3R2. The involvement of sAC and IP3R2 in this process is crucial.
Article
Medicine, Research & Experimental
Hao Zhang, Kun Zhu, Xuefeng Zhang, Yihui Ding, Bing Zhu, Wen Meng, Fan Zhang
Summary: This study found that RUT can alleviate LPS-induced lung cell injury by inhibiting ER stress via the activation of the AMPK/SIRT1 signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jessica L. Braun, Mia S. Geromella, Sophie I. Hamstra, Holt N. Messner, Val A. Fajardo
Summary: Microgravity exposure causes muscle weakness and atrophy, with differences observed in SERCA function and RONS protein adduction between soleus and TA muscles. The impairment in Ca2+ uptake in soleus muscles may be attributed to increased RONS production, while the enhancement in TA muscles could be due to a shift towards faster muscle fiber types without elevated protein nitration and nitrosylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
A. T. Duarte-Silva, L. G. R. Ximenes, M. Guimaraes-Souza, I. Domith, R. Paes-de-Carvalho
Summary: The communication and interaction between developing neurons and neurotransmitters play crucial roles in the regulation of signaling pathways during central nervous system development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Arianne Papa, Jared Kushner, Jessica A. Hennessey, Alexander N. Katchman, Sergey Zakharov, Bi-xing Chen, Lin Yang, Ree Lu, Stephen Leong, Johanna Diaz, Guoxia Liu, Daniel Roybal, Xianghai Liao, Pedro J. del Rivero Morfin, Henry M. Colecraft, Geoffrey S. Pitt, Oliver Clarke, Veli Topkara, Manu Ben-Johny, Steven O. Marx
Summary: The study identified that the activity of Ca(V)1.2 channels is dynamically modulated by factors converging at the alpha(1C) I-II loop under different conditions, including basal conditions, beta-adrenergic stimulation, and heart failure. This has significant implications for cardiac physiology and pathophysiology.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ronja Schiemann, Annika Buhr, Eva Cordes, Stefan Walter, Jurgen J. Heinisch, Paola Ferrero, Hendrik Milting, Achim Paululat, Heiko Meyer
Summary: In this study, the researchers found that the endopeptidase Neprilysin 4 plays an essential role in regulating SERCA and maintaining Ca2+ homeostasis in cardiomyocytes, thus contributing to proper heart function.
NATURE COMMUNICATIONS
(2022)
Review
Physiology
Shanna Hamilton, Dmitry Terentyev
Summary: The sarcoplasmic reticulum (SR) in cardiomyocytes not only regulates calcium ions, but also performs important functions of endoplasmic reticulum (ER) in other cell types. Recent studies have found that ER stress in the heart plays a crucial role in causing cardiac arrhythmias.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemical Research Methods
Paul Dowling, Dieter Swandulla, Kay Ohlendieck
Summary: This article outlines the proteomic profiling of membrane proteins and large protein assemblies in skeletal muscles, including a critical overview of separation techniques and mass spectrometric approaches. The proteomic detection and characterization of the Ca2+-ATPase of the sarcoplasmic reticulum is discussed as an illustrative example. The biological role of this large protein complex in normal muscle functioning is evaluated from a proteomics perspective.
EXPERT REVIEW OF PROTEOMICS
(2023)
Article
Endocrinology & Metabolism
Xiwen Xiong, Gaihong Wang, Rongya Tao, Pengfei Wu, Tatsuyoshi Kono, Kevin Li, Wen-Xing Ding, Xin Tong, Sarah A. Tersey, Robert A. Harris, Raghavendra G. Mirmira, Carmella Evans-Molina, X. Charlie Dong
Article
Endocrinology & Metabolism
Tatsuyoshi Kono, Xin Tong, Solaema Taleb, Robert N. Bone, Hitoshi Iida, Chih-Chun Lee, Paul Sohn, Patrick Gilon, Michael W. Roe, Carmella Evans-Molina
Article
Multidisciplinary Sciences
Masayuki Hatanaka, Emily Anderson-Baucum, Alexander Lakhter, Tatsuyoshi Kono, Bernhard Maier, Sarah A. Tersey, Yukio Tanizawa, Carmella Evans-Molina, Raghavendra G. Mirmira, Emily K. Sims
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Wataru R. Yamamoto, Robert N. Bone, Paul Sohn, Farooq Syed, Christopher A. Reissaus, Amber L. Mosley, Aruna B. Wijeratne, Jason D. True, Xin Tong, Tatsuyoshi Kono, Carmella Evans-Molina
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Rachana Haliyur, Xin Tong, May Sanyoura, Shristi Shrestha, Jill Lindner, Diane C. Saunders, Radhika Aramandla, Greg Poffenberger, Sambra D. Redick, Rita Bottino, Nripesh Prasad, Shawn E. Levy, Raymond D. Blind, David M. Harlan, Louis H. Philipson, Roland W. Stein, Marcela Brissova, Alvin C. Powers
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Endocrinology & Metabolism
Xin Tong, Chunhua Dai, John T. Walker, Gopika G. Nair, Arion Kennedy, Rotonya M. Carr, Matthias Hebrok, Alvin C. Powers, Roland Stein
Article
Endocrinology & Metabolism
Xin Tong, Zunaira Chaudhry, Chih-Chun Lee, Robert N. Bone, Sukrati Kanojia, Judith Maddatu, Paul Sohn, Staci A. Weaver, Morgan A. Robertson, Irina Petrache, Carmella Evans-Molina, Tatsuyoshi Kono
MOLECULAR METABOLISM
(2020)
Article
Cell Biology
Shijun Yan, Jason M. Conley, Austin M. Reilly, Natalie D. Stull, Surabhi D. Abhyankar, Aaron C. Ericsson, Tatsuyoshi Kono, Andrei Molosh, Chandrashekhar A. Kubal, Carmella Evans-Molina, Hongxia Ren
Summary: The orphan G protein-coupled receptor Gpr17 inhibits the secretion of glucagon-like peptide-1 (GLP-1) in intestinal enteroendocrine cells. Genetic ablation or agonistic action of Gpr17 can increase the secretion of GLP-1.
Article
Endocrinology & Metabolism
Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
Summary: The activity of Pdx1 is regulated by Chd4, which controls chromatin accessibility, histone modifications, and nucleosome distribution. Loss of Chd4 in beta-cells leads to glucose intolerance, defects in insulin secretion, and altered expression of genes critical for beta-cell function. These findings demonstrate the importance of Chd4 in maintaining beta-cell function.
Article
Endocrinology & Metabolism
Hitoshi Iida, Tatsuyoshi Kono, Chih-Chun Lee, Preethi Krishnan, Matthew C. Arvin, Staci A. Weaver, Timothy S. Jarvela, Renato C. S. Branco, Madeline R. McLaughlin, Robert N. Bone, Xin Tong, Peter Arvan, Iris Lindberg, Carmella Evans-Molina
Summary: Increased circulating levels of incompletely processed insulin are observed in diabetes. This study reveals that the deficiency of SERCA2, an ER Ca2+ regulator, leads to impaired insulin processing in beta cells. The findings highlight the importance of ER Ca2+ homeostasis in proinsulin processing and provide potential therapeutic targets for diabetes.
Article
Endocrinology & Metabolism
Emily K. Sims, Alexander J. Lakhter, Emily Anderson-Baucum, Tatsuyoshi Kono, Xin Tong, Carmella Evans-Molina