Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis

(2018) Niklas Mueller et al.   BLOOD

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EMT: Mechanisms and therapeutic implications

(2018) Mohini Singh et al.   PHARMACOLOGY & THERAPEUTICS

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

(2018) Virginia Murillo-Garzón et al.   Nature Communications

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Melanoma

(2018) Dirk Schadendorf et al.   LANCET

LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway

(2018) Ang Gao et al.   Nature Communications

RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis

(2017) Rong Geng et al.   Cell Death & Disease

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

(2017) Coralie Dorard et al.   Nature Communications

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

(2017) Pedro M. Aponte et al.   Stem Cells International

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1

(2016) Guanhua Song et al.   NATURE IMMUNOLOGY

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Downregulation of RNF128 Predicts Progression and Poor Prognosis in Patients with Urothelial Carcinoma of the Upper Tract and Urinary Bladder

(2016) Yi-Ying Lee et al.   Journal of Cancer

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals

(2015) Jingjing Qi et al.   GUT

Ubiquitin-specific protease 7 accelerates p14ARFdegradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression

(2015) Jia-Bin Cai et al.   HEPATOLOGY

Diminished WNT ->  -catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors

(2014) J. Juan et al.   GENES & DEVELOPMENT

Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

(2014) Irene Miranda-Lorenzo et al.   NATURE METHODS

Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis

(2013) Y-C Chen et al.   CELL DEATH AND DIFFERENTIATION

αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma

(2013) Xiao-Yong Huang et al.   HEPATOLOGY

Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn’s disease

(2013) Akira Mukai et al.   JOURNAL OF GASTROENTEROLOGY

RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors

(2012) Y. Su et al.   CLINICAL CANCER RESEARCH

Cortactin in cell migration and cancer at a glance

(2012) S. M. MacGrath et al.   JOURNAL OF CELL SCIENCE

A new paradigm tumor for drug development

(2012) Alexander M. M. Eggermont et al.   Nature Reviews Clinical Oncology

Enhanced top-down characterization of histone post-translational modifications

(2012) Zhixin Tian et al.   GENOME BIOLOGY

CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial–Mesenchymal Transition in HCC Cells

(2011) Ai–Wu Ke et al.   GASTROENTEROLOGY

GRAIL (Gene Related to Anergy in Lymphocytes) Regulates Cytoskeletal Reorganization through Ubiquitination and Degradation of Arp2/3 Subunit 5 and Coronin 1A

(2011) Daiju Ichikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

(2010) Annabelle Lewis et al.   GUT

The E3 Ubiquitin Ligase GRAIL Regulates T Cell Tolerance and Regulatory T Cell Function by Mediating T Cell Receptor-CD3 Degradation

(2010) Roza I. Nurieva et al.   IMMUNITY

RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer

(2008) Qiang Zhang et al.   CELL RESEARCH