4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis

Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

(2018) Simone Carradori et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MAO inhibitors and their wider applications: a patent review

(2018) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis

(2018) Joana Reis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological aspects of the neuroprotective effects of irreversible MAO-B inhibitors, selegiline and rasagiline, in Parkinson’s disease

(2018) Éva Szökő et al.   JOURNAL OF NEURAL TRANSMISSION

In vitro and in silico studies of antioxidant activity of 2-thiazolylhydrazone derivatives

(2018) Vinícius Gonçalves Maltarollo et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α -glucosidase inhibitory activity, and in silico studies

(2017) Farman Ali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Use of monoamine oxidase inhibitors in chronic neurodegeneration

(2017) Peter Riederer et al.   Expert Opinion on Drug Metabolism & Toxicology

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

(2017) Sophia Schedin-Weiss et al.   Alzheimers Research & Therapy

Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations

(2016) Marcello Locatelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Indanones As High-Potency Reversible Inhibitors of Monoamine Oxidase

(2015) Samantha Mostert et al.   ChemMedChem

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies

(2015) Melissa D’Ascenzio et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

New Frontiers in Selective Human MAO-B Inhibitors

(2015) Simone Carradori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two Ganoderma species: profiling of phenolic compounds by HPLC–DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders

(2015) Gokhan Zengin et al.   Food & Function

Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors

(2014) Melissa D’Ascenzio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: Structural design, synthesis and pharmacological evaluation

(2014) Marcos Veríssimo de Oliveira Cardoso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel monoamine oxidase inhibitors: a patent review (2012 – 2014)

(2014) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss. endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer, skin diseases and type II diabetes

(2014) Gokhan Zengin et al.   INDUSTRIAL CROPS AND PRODUCTS

Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors

(2013) Paola Chimenti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species

(2013) Abdurrahman Aktumsek et al.   FOOD AND CHEMICAL TOXICOLOGY

The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease

(2013) Li Zuo et al.   GENE

Novel potential agents for ulcerative colitis by molecular topology: suppression of IL-6 production in Caco-2 and RAW 264.7 cell lines

(2013) María Galvez-Llompart et al.   MOLECULAR DIVERSITY

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

(2013) Moussa B.H. Youdim et al.   PARKINSONISM & RELATED DISORDERS

Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

(2013) Jonah Cheung et al.   ACS Medicinal Chemistry Letters

Synthesis and Selective Human Monoamine Oxidase B Inhibition of Heterocyclic Hybrids Based on Hydrazine and Thiazole Scaffolds

(2012) Simone Carradori et al.   ARCHIV DER PHARMAZIE

Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines

(2012) Daniela Secci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Patent-related survey on new monoamine oxidase inhibitors and their therapeutic potential

(2012) Simone Carradori et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase

(2011) Anél Petzer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The use of multi-target drugs in the treatment of neurodegenerative diseases

(2011) Cornelis J Van der Schyf   Expert Review of Clinical Pharmacology

Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors

(2010) Franco Chimenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigations on the 2-thiazolylhydrazyne scaffold: Synthesis and molecular modeling of selective human monoamine oxidase inhibitors

(2010) Franco Chimenti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Focusing on new monoamine oxidase inhibitors

(2010) Adriana Bolasco et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis, Stereochemical Separation, and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines

(2010) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and selective inhibition of human monoamine oxidases of a large scaffold of (4,5-substituted-thiazol-2-yl)hydrazones

(2010) Franco Chimenti et al.   MedChemComm

An expert opinion on safinamide in Parkinson's disease

(2008) Marco Onofrj et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Synthesis, Stereochemical Identification, and Selective Inhibitory Activity against Human Monoamine Oxidase-B of 2-Methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors

(2008) S.-Y. Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA