Time-Resolved Macromolecular Crystallography at Pulsed X-ray Sources

Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography

(2018) Jose L. Olmos et al.   BMC BIOLOGY

Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM

(2018) Andrii Ishchenko et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser

(2018) Przemyslaw Nogly et al.   SCIENCE

Radiation Damage in Macromolecular Crystallography—An Experimentalist’s View

(2018) Helena Taberman   Crystals

Megahertz data collection from protein microcrystals at an X-ray free-electron laser

(2018) Marie Luise Grünbein et al.   Nature Communications

Megahertz serial crystallography

(2018) Max O. Wiedorn et al.   Nature Communications

Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome

(2018) Nicole C. Woitowich et al.   IUCrJ

Rapid sample delivery for megahertz serial crystallography at X-ray FELs

(2018) Max O. Wiedorn et al.   IUCrJ

Structures of the intermediates of Kok’s photosynthetic water oxidation clock

(2018) Jan Kern et al.   NATURE

Populations and coherence in femtosecond time resolved X-ray crystallography of the photoactive yellow protein

(2017) Christopher D.M. Hutchison et al.   INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY

Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL

(2017) Michihiro Suga et al.   NATURE

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

(2017) J. R. Stagno et al.   NATURE

Fluorescence nanoscopy in cell biology

(2017) Steffen J. Sahl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of dimer asymmetry and protomer dynamics in enzyme catalysis

(2017) Tae Hun Kim et al.   SCIENCE

Pink-beam serial crystallography

(2017) A. Meents et al.   Nature Communications

Mix-and-diffuse serial synchrotron crystallography

(2017) Kenneth R. Beyerlein et al.   IUCrJ

Experimental phasing of serial femtosecond crystallography data

(2017) Ilme Schlichting   IUCrJ

Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation

(2017) Jose M. Martin-Garcia et al.   IUCrJ

A short history of structure based research on the photocycle of photoactive yellow protein

(2017) Marius Schmidt   Structural Dynamics

A nanosecond time-resolved XFEL analysis of structural changes associated with CO release from cytochrome c oxidase

(2017) Atsuhiro Shimada et al.   Science Advances

Long-range allosteric signaling in red light–regulated diguanylyl cyclases

(2017) Geoffrey Gourinchas et al.   Science Advances

Hydroxyethyl cellulose matrix applied to serial crystallography

(2017) Michihiro Sugahara et al.   Scientific Reports

Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism

(2016) Lisandro Horacio Otero et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of photosystem II and substrate binding at room temperature

(2016) Iris D. Young et al.   NATURE

Dynamics from noisy data with extreme timing uncertainty

(2016) R. Fung et al.   NATURE

Liquid explosions induced by X-ray laser pulses

(2016) Claudiu A. Stan et al.   Nature Physics

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

(2016) K. Pande et al.   SCIENCE

A three-dimensional movie of structural changes in bacteriorhodopsin

(2016) Eriko Nango et al.   SCIENCE

Crystal Structure of Deinococcus Phytochrome in the Photoactivated State Reveals a Cascade of Structural Rearrangements during Photoconversion

(2016) E. Sethe Burgie et al.   STRUCTURE

Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography

(2016) Christian G. Roessler et al.   STRUCTURE

Recent developments inCrystFEL

(2016) Thomas A. White et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers

(2016) George D. Calvey et al.   Structural Dynamics

Structural enzymology using X-ray free electron lasers

(2016) Christopher Kupitz et al.   Structural Dynamics

The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography

(2016) Petra Edlund et al.   Scientific Reports

Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography

(2015) Haitao Zhang et al.   CELL

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Concentric-flow electrokinetic injector enables serial crystallography of ribosome and photosystem II

(2015) Raymond G Sierra et al.   NATURE METHODS

Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation

(2015) T. R. M. Barends et al.   SCIENCE

Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser

(2015) Matteo Levantino et al.   Nature Communications

A micro-patterned silicon chip as sample holder for macromolecular crystallography experiments with minimal background scattering

(2015) P. Roedig et al.   Scientific Reports

Lipidic cubic phase serial millisecond crystallography using synchrotron radiation

(2015) Przemyslaw Nogly et al.   IUCrJ

Indications of radiation damage in ferredoxin microcrystals using high-intensity X-FEL beams

(2015) Karol Nass et al.   JOURNAL OF SYNCHROTRON RADIATION

Superoxide Dismutases and Superoxide Reductases

(2014) Yuewei Sheng et al.   CHEMICAL REVIEWS

Signal to noise considerations for single crystal femtosecond time resolved crystallography of the Photoactive Yellow Protein

(2014) Jasper J. van Thor et al.   FARADAY DISCUSSIONS

Signal amplification and transduction in phytochrome photosensors

(2014) Heikki Takala et al.   NATURE

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

(2014) Christopher Kupitz et al.   NATURE

Native structure of photosystem II at 1.95 Å resolution viewed by femtosecond X-ray pulses

(2014) Michihiro Suga et al.   NATURE

Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser

(2014) David Arnlund et al.   NATURE METHODS

Grease matrix as a versatile carrier of proteins for serial crystallography

(2014) Michihiro Sugahara et al.   NATURE METHODS

Sub-femtosecond precision measurement of relative X-ray arrival time for free-electron lasers

(2014) N. Hartmann et al.   Nature Photonics

Time-resolved crystallography and protein design: signalling photoreceptors and optogenetics

(2014) K. Moffat   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Crystal structure of the photosensing module from a red/far-red light-absorbing plant phytochrome

(2014) E. S. Burgie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

(2014) Jason Tenboer et al.   SCIENCE

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

(2014) Uwe Weierstall et al.   Nature Communications

Room-temperature macromolecular serial crystallography using synchrotron radiation

(2014) Francesco Stellato et al.   IUCrJ

In situserial Laue diffraction on a microfluidic crystallization device

(2014) Sarah L. Perry et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Cheetah: software for high-throughput reduction and analysis of serial femtosecond X-ray diffraction data

(2014) Anton Barty et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Protein energy landscapes determined by five-dimensional crystallography

(2013) Marius Schmidt et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms

(2013) Oliver P. Ernst et al.   CHEMICAL REVIEWS

Volume-conserving trans–cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography

(2013) Yang Ouk Jung et al.   Nature Chemistry

Achieving few-femtosecond time-sorting at hard X-ray free-electron lasers

(2013) M. Harmand et al.   Nature Photonics

New antibiotics for bad bugs: where are we?

(2013) Matteo Bassetti et al.   Annals of Clinical Microbiology and Antimicrobials

Breaking the indexing ambiguity in serial crystallography

(2013) Wolfgang Brehm et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

pH Dependence of the Photoactive Yellow Protein Photocycle Investigated by Time-Resolved Crystallography

(2012) Shailesh Tripathi et al.   BIOPHYSICAL JOURNAL

CrystFEL: a software suite for snapshot serial crystallography

(2012) Thomas A. White et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Laue crystal structure of Shewanella oneidensis cytochrome c nitrite reductase from a high-yield expression system

(2012) Matthew Youngblut et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The AGIPD detector for the European XFEL

(2012) D Greiffenberg   Journal of Instrumentation

The kinetic dose limit in room-temperature time-resolved macromolecular crystallography

(2012) M. Schmidt et al.   JOURNAL OF SYNCHROTRON RADIATION

Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography

(2012) F. Schotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-factor analysis of femtosecond microdiffraction patterns from protein nanocrystals

(2011) Richard A. Kirian et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

X-ray Diffraction from Membrane Protein Nanocrystals

(2011) M.S. Hunter et al.   BIOPHYSICAL JOURNAL

Bacterial phytochromes: More than meets the light

(2011) Michele E. Auldridge et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

BioCARS: a synchrotron resource for time-resolved X-ray science

(2011) T. Graber et al.   JOURNAL OF SYNCHROTRON RADIATION

Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å

(2011) Yasufumi Umena et al.   NATURE

Femtosecond X-ray protein nanocrystallography

(2011) Henry N. Chapman et al.   NATURE

Spectral encoding of x-ray/optical relative delay

(2011) Mina R. Bionta et al.   OPTICS EXPRESS

Fluorescence quantum yield and photochemistry of bacteriophytochrome constructs

(2011) K. C. Toh et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser

(2011) Lukas Lomb et al.   PHYSICAL REVIEW B

The minimum crystal size needed for a complete diffraction data set

(2010) James M. Holton et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms

(2010) Sarah Sainsbury et al.   JOURNAL OF MOLECULAR BIOLOGY

Femtosecond protein nanocrystallography—data analysis methods

(2010) Richard A. Kirian et al.   OPTICS EXPRESS

Time-resolved pump-probe experiments at the LCLS

(2010) James M. Glownia et al.   OPTICS EXPRESS

Engineered photoreceptors as novel optogenetic tools

(2010) Andreas Möglich et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Beta-lactam antibiotics: from antibiosis to resistance and bacteriology

(2009) KOK-FAI KONG et al.   APMIS

Mammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome

(2009) X. Shu et al.   SCIENCE

Mutational Analysis ofDeinococcus radioduransBacteriophytochrome Reveals Key Amino Acids Necessary for the Photochromicity and Proton Exchange Cycle of Phytochromes

(2008) Jeremiah R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gas dynamic virtual nozzle for generation of microscopic droplet streams

(2008) D P DePonte et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS