Structural enzymology using X-ray free electron lasers

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

(2017) J. R. Stagno et al.   NATURE

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein

(2016) K. Pande et al.   SCIENCE

Mixing injector enables time-resolved crystallography with high hit rate at X-ray free electron lasers

(2016) George D. Calvey et al.   Structural Dynamics

Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the β-Lactamase from Mycobacterium tuberculosis

(2015) Saugata Hazra et al.   BIOCHEMISTRY

Overcoming differences: The catalytic mechanism of metallo-β-lactamases

(2015) María-Rocío Meini et al.   FEBS LETTERS

Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance

(2015) Jeong Jeon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation

(2015) T. R. M. Barends et al.   SCIENCE

The Coherent X-ray Imaging instrument at the Linac Coherent Light Source

(2015) Mengning Liang et al.   JOURNAL OF SYNCHROTRON RADIATION

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser

(2014) Christopher Kupitz et al.   NATURE

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

(2014) Jason Tenboer et al.   SCIENCE

Double-focusing mixing jet for XFEL study of chemical kinetics

(2014) Dingjie Wang et al.   JOURNAL OF SYNCHROTRON RADIATION

Volume-conserving trans–cis isomerization pathways in photoactive yellow protein visualized by picosecond X-ray crystallography

(2013) Yang Ouk Jung et al.   Nature Chemistry

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Directed Evolution of Mycobacterium tuberculosis β-Lactamase Reveals Gatekeeper Residue That Regulates Antibiotic Resistance and Catalytic Efficiency

(2013) Christian Feiler et al.   PLoS One

Mix and Inject: Reaction Initiation by Diffusion for Time-Resolved Macromolecular Crystallography

(2013) Marius Schmidt   Advances in Condensed Matter Physics

Metallo-β-lactamase structure and function

(2012) Timothy Palzkill   Annals of the New York Academy of Sciences

Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1by Carbapenems and Cephalosporins

(2012) Vincent Dubée et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Watching a signaling protein function in real time via 100-ps time-resolved Laue crystallography

(2012) F. Schotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

(2012) S. Boutet et al.   SCIENCE

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

Structures of the Michaelis Complex (1.2 Å) and the Covalent Acyl Intermediate (2.0 Å) of Cefamandole Bound in the Active Sites of theMycobacterium tuberculosisβ-Lactamase K73A and E166A Mutants,

(2010) Lee W. Tremblay et al.   BIOCHEMISTRY

Biochemical and Structural Characterization ofMycobacterium tuberculosisβ-Lactamase with the Carbapenems Ertapenem and Doripenem

(2010) Lee W. Tremblay et al.   BIOCHEMISTRY

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

Structure of the Covalent Adduct Formed between Mycobacterium tuberculosis β-Lactamase and Clavulanate†‡

(2008) Lee W. Tremblay et al.   BIOCHEMISTRY