The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art

Exogenous hydrogen sulfide protects from endothelial cell damage, platelet activation, and neutrophils extracellular traps formation in hyperhomocysteinemia rats

(2018) Ziqing Zhao et al.   EXPERIMENTAL CELL RESEARCH

Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans

(2018) Joanna Perła-Kaján et al.   FASEB JOURNAL

Endothelial Aquaporins and Hypomethylation: Potential Implications for Atherosclerosis and Cardiovascular Disease

(2018) Inês da Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy?

(2018) Matthew F. Yuyun et al.   MICROVASCULAR RESEARCH

Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine

(2018) Xinya Xie et al.   MOLECULAR MEDICINE

Altered Redox Homeostasis in Branched-Chain Amino Acid Disorders, Organic Acidurias, and Homocystinuria

(2018) Eva Richard et al.   Oxidative Medicine and Cellular Longevity

Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width

(2018) Ziwei Dai et al.   Nature Communications

Reverse Cholesterol Transport: Molecular Mechanisms and the Non-medical Approach to Enhance HDL Cholesterol

(2018) Leandro R. Marques et al.   Frontiers in Physiology

Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling

(2018) Shih-Hung Chan et al.   Redox Biology

Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial

(2018) K. Borowczyk et al.   JOURNAL OF INTERNAL MEDICINE

Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis

(2018) Xun Wu et al.   Redox Biology

Mechanisms of foam cell formation in atherosclerosis

(2017) Dimitry A. Chistiakov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis

(2017) Junjie Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

Structural changes of fibrinogen molecule mediated by the N-homocysteinylation reaction

(2017) Valeria Genoud et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

One-carbon metabolism and epigenetics

(2017) Simonetta Friso et al.   MOLECULAR ASPECTS OF MEDICINE

Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer

(2017) John I. Toohey   MOLECULES

The metabolism and significance of homocysteine in nutrition and health

(2017) Avinash Kumar et al.   Nutrition & Metabolism

Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

(2017) Zhimin Zhang et al.   Oxidative Medicine and Cellular Longevity

Understanding RNA modifications: the promises and technological bottlenecks of the ‘epitranscriptome’

(2017) Matthias Schaefer et al.   Open Biology

Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis

(2017) Junjie Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes

(2017) Shyam Sundar Nandi et al.   Scientific Reports

Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress

(2017) Riyaz Mohamed et al.   Scientific Reports

S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation

(2016) Madalena Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Clinical Update: Cardiovascular Disease in Diabetes Mellitus

(2016) Cecilia C. Low Wang et al.   CIRCULATION

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration

(2016) Sounik Saha et al.   FASEB JOURNAL

Homocysteine lowering for stroke prevention: Unravelling the complexity of the evidence

(2016) J David Spence   International Journal of Stroke

Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress

(2016) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification

(2016) Ruifan Wu et al.   MOLECULAR BIOTECHNOLOGY

Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

(2015) Dorota Gurda et al.   AMINO ACIDS

Homocysteine-Induced Endothelial Dysfunction

(2015) Wai Keung Christopher Lai et al.   ANNALS OF NUTRITION AND METABOLISM

One-carbon metabolism and epigenetics: understanding the specificity

(2015) Samantha J. Mentch et al.   Annals of the New York Academy of Sciences

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Low nourishment of B-vitamins is associated with hyperhomocysteinemia and oxidative stress in newly diagnosed cardiac patients

(2015) Mostafa I. Waly et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism

(2015) Yunjun Xiao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Inflammation and plaque vulnerability

(2015) G. K. Hansson et al.   JOURNAL OF INTERNAL MEDICINE

Global histone H3 lysine 27 triple methylation levels are reduced in vessels with advanced atherosclerotic plaques

(2015) Rutger J. Wierda et al.   LIFE SCIENCES

Noncoding RNAs in eukaryotic ribosome biogenesis and function

(2015) Denis L J Lafontaine   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

(2015) Rudolf Napieralski et al.   THROMBOSIS AND HAEMOSTASIS

Protein N-linked homocysteine is associated with recurrence of venous thromboembolism

(2015) Anastazja Szlauer et al.   THROMBOSIS RESEARCH

The role of H2S bioavailability in endothelial dysfunction

(2015) Rui Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Noncoding RNAs in eukaryotic ribosome biogenesis and function

(2015) Denis L J Lafontaine   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes

(2015) Antonysunil Adaikalakoteswari et al.   Clinical Epigenetics

Platelets in Inflammation and Atherogenesis

(2015) Henry M. Nording et al.   Frontiers in Immunology

Endothelial Dysfunction: The Link Between Homocysteine and Hydrogen Sulfide

(2014) Sathnur Pushpakumar et al.   CURRENT MEDICINAL CHEMISTRY

Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

(2014) Zaid Altaany et al.   CURRENT MEDICINAL CHEMISTRY

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency

(2014) Ruben Esse et al.   FASEB JOURNAL

Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression

(2014) Madalena Barroso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant DNA methylation of the PDGF gene in homocysteine-mediated VSMC proliferation and its underlying mechanism

(2014) XUE-BO HAN et al.   Molecular Medicine Reports

The functional diversity of protein lysine methylation

(2014) S. Lanouette et al.   Molecular Systems Biology

Anti-Atherogenic Effect of Hydrogen Sulfide by Over-Expression of Cystathionine Gamma-Lyase (CSE) Gene

(2014) Sau Ha Cheung et al.   PLoS One

Methylated nucleosides in tRNA and tRNA methyltransferases

(2014) Hiroyuki Hori   Frontiers in Genetics

Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia

(2013) Ruben Esse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endothelial dysfunction — A major mediator of diabetic vascular disease

(2013) Cristina M. Sena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E−/−mice

(2013) Zhen Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis

(2013) Sarathi Mani et al.   CIRCULATION

Cystathionine  -Lyase Protects against Renal Ischemia/Reperfusion by Modulating Oxidative Stress

(2013) E. M. Bos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation

(2013) RONG SUO et al.   Molecular Medicine Reports

Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress

(2013) Ya-Dan Wen et al.   PLoS One

Correction: Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells

(2013) Ruben Esse et al.   PLoS One

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

(2013) S.-K. Myung et al.   BMJ-British Medical Journal

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer

(2012) Xavier Tekpli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Updating the Relationship between Hyperhomocysteinemia Lowering Therapy and Cardiovascular Events

(2012) Xiaoshu Cheng   Cardiovascular Therapeutics

Protection of DDAH2 Overexpression Against Homocysteine-Induced Impairments of DDAH/ADMA/NOS/NO Pathway in Endothelial Cells

(2012) Li-Hua Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

Homocysteine Imbalance: a Pathological Metabolic Marker

(2012) Kevin L. Schalinske et al.   Advances in Nutrition

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities

(2011) Rinrada Kietadisorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: role of heme oxygenase-1

(2011) Mozow Y. Zuidema et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Homocysteine-Induced Apoptosis in Endothelial Cells Coincides With Nuclear NOX2 and Peri-nuclear NOX4 Activity

(2011) Jessica A. Sipkens et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Signaling pathways for the vascular effects of hydrogen sulfide

(2011) Rui Wang   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1

(2011) Maira Moreno Garcia et al.   JOURNAL OF PATHOLOGY

Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) expression is epigenetically regulated by one-carbon metabolism in invasive duct cell carcinoma of breast

(2011) Shaik Mohammad Naushad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47phox

(2011) Jessica A. Sipkens et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis

(2011) David S. Wald et al.   PLoS One

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

From endothelial dysfunction to atherosclerosis

(2010) S. Sitia et al.   AUTOIMMUNITY REVIEWS

Hydrogen sulphide and angiogenesis: mechanisms and applications

(2010) Csaba Szabó et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders

(2010) Jan F. Gielis et al.   FREE RADICAL BIOLOGY AND MEDICINE

The homocysteine controversy

(2010) Yvo M. Smulders et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur

(2010) Martha H. Stipanuk et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes

(2009) L. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

H2S Biogenesis by Human Cystathionine γ-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia

(2009) Taurai Chiku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions

(2009) Sangita Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?

(2009) Matthew Whiteman et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Hydrogen sulfide is an endogenous stimulator of angiogenesis

(2009) A. Papapetropoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocyte-Endothelial Cell Interactions in the Development of Atherosclerosis

(2009) Javier Mestas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia

(2008) Sanjana Dayal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice

(2008) Yanfei Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Kinetic Properties of Polymorphic Variants and Pathogenic Mutants in Human Cystathionine γ-Lyase†

(2008) Weidong Zhu et al.   BIOCHEMISTRY

H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G

(2008) S Muzaffar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients

(2008) Alessandro Valli et al.   CLINICA CHIMICA ACTA

Mutations in cystathionine β-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans

(2008) Hieronim Jakubowski et al.   FASEB JOURNAL

Effect of Folic Acid and B Vitamins on Risk of Cardiovascular Events and Total Mortality Among Women at High Risk for Cardiovascular Disease

(2008) Christine M. Albert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Translating molecular discoveries into new therapies for atherosclerosis

(2008) Daniel J. Rader et al.   NATURE

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE

Dietary methionine effects on plasma homocysteine and HDL metabolism in mice

(2007) Wanda Velez-Carrasco et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY