Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders

Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model

(2018) Kozo Saito et al.   GLIA

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

(2018) Nicole Reichenbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation

(2018) Yutaka Hoshi et al.   JOURNAL OF NEUROSCIENCE

Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+Dynamics in Astrocytes

(2018) Eiji Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Gliotransmission: Beyond Black-and-White

(2018) Iaroslav Savtchouk et al.   JOURNAL OF NEUROSCIENCE

Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions

(2018) Todd A. Fiacco et al.   JOURNAL OF NEUROSCIENCE

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

(2018) Jillian L. Stobart et al.   NEURON

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Fluorescent Ca2+indicators directly inhibit the Na,K-ATPase and disrupt cellular functions

(2018) Nathan A. Smith et al.   Science Signaling

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes

(2018) Letizia Mariotti et al.   Nature Communications

Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

(2018) Grace O. Mizuno et al.   Cell Reports

Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes

(2018) Qiping Dong et al.   eLife

Fluorescent Ca2+indicators directly inhibit the Na,K-ATPase and disrupt cellular functions

(2018) Nathan A. Smith et al.   Science Signaling

Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

(2018) Alex Plata et al.   Frontiers in Molecular Neuroscience

Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus

(2018) Heejung Chun et al.   Experimental Neurobiology

Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity

(2018) Kjell Heuser et al.   CEREBRAL CORTEX

Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents

(2018) Marta Gómez-Gonzalo et al.   GLIA

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior

(2018) Xinzhu Yu et al.   NEURON

Inositol 1,4,5-trisphosphate receptor type 2-independent Ca2+ release from the endoplasmic reticulum in astrocytes

(2018) Yohei Okubo et al.   GLIA

Spontaneous astrocytic Ca2+ activity abounds in electrically suppressed ischemic penumbra of aged mice

(2018) Jonas Christoffer Fordsmann et al.   GLIA

Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis

(2018) Ljiljana Nikolic et al.   GLIA

Conditional Knockout of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake

(2018) Anthony D. Umpierre et al.   JOURNAL OF NEUROSCIENCE

Versatile control of synaptic circuits by astrocytes: where, when and how?

(2018) Glenn Dallérac et al.   NATURE REVIEWS NEUROSCIENCE

Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

(2018) Mario Wellmann et al.   Frontiers in Cellular Neuroscience

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes

(2018) Jeffrey R. Jones et al.   Cell Reports

Astrocytic IP3Rs: Contribution to Ca2+signalling and hippocampal LTP

(2017) Mark William Sherwood et al.   GLIA

TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model

(2017) Cordula Rakers et al.   GLIA

Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning

(2017) Yuri Hirayama et al.   GLIA

Astrocyte-mediated synapse remodeling in the pathological brain

(2017) Sun Kwang Kim et al.   GLIA

Molecular and Functional Properties of Regional Astrocytes in the Adult Brain

(2017) Lydie Morel et al.   JOURNAL OF NEUROSCIENCE

TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

(2017) Anthony Bosson et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

(2017) Masamitsu Hara et al.   NATURE MEDICINE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

cAMP-Dependent Calcium Oscillations of Astrocytes: An Implication for Pathology

(2016) Sakiko Ujita et al.   CEREBRAL CORTEX

Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes

(2016) Lara Buscemi et al.   CEREBRAL CORTEX

Ca2+transients in astrocyte fine processes occur via Ca2+influx in the adult mouse hippocampus

(2016) Ravi L. Rungta et al.   GLIA

Genetic ablation of IP3receptor 2 increases cytokines and decreases survival ofSOD1G93Amice

(2016) Kim A. Staats et al.   HUMAN MOLECULAR GENETICS

Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model

(2016) Cordula Rakers et al.   JOURNAL OF CLINICAL INVESTIGATION

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain

(2016) Sun Kwang Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease

(2016) Kuan-I Lee et al.   Journal of Neuroinflammation

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

(2016) R. Jiang et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Probing the Complexities of Astrocyte Calcium Signaling

(2016) Eiji Shigetomi et al.   TRENDS IN CELL BIOLOGY

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

(2016) Hiromu Monai et al.   Nature Communications

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

(2016) Gertrudis Perea et al.   eLife

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

Disruption of IP3R2-mediated Ca2+ signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal ischemic stroke

(2015) Hailong Li et al.   CELL CALCIUM

Enhanced astroglial Ca2+signaling increases excitatory synaptic strength in the epileptic brain

(2015) Carla Álvarez-Ferradas et al.   GLIA

Astrocyte-Mediated Ischemic Tolerance

(2015) Y. Hirayama et al.   JOURNAL OF NEUROSCIENCE

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein

(2015) Baljit S. Khakh et al.   Cold Spring Harbor Perspectives in Biology

Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation

(2015) J. Michael Gee et al.   Frontiers in Molecular Neuroscience

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway

(2014) Martin D. Haustein et al.   NEURON

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage

(2014) Kaoru Beppu et al.   NEURON

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

(2014) Zheng Wu et al.   Nature Communications

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

In Vivo Visualization of Subtle, Transient, and Local Activity of Astrocytes Using an Ultrasensitive Ca2+ Indicator

(2014) Kazunori Kanemaru et al.   Cell Reports

Antagonism of purinergic signalling improves recovery from traumatic brain injury

(2013) Anthony M. Choo et al.   BRAIN

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

(2013) Fengfei Ding et al.   CELL CALCIUM

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

(2013) Takahiro Takano et al.   GLIA

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors

(2013) Amulya Nidhi Shrivastava et al.   GLIA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

(2013) Eiji Shigetomi et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release

(2013) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia

(2013) Qi-ping Dong et al.   NEUROBIOLOGY OF DISEASE

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury

(2013) K. Kanemaru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses

(2013) Mika Tanaka et al.   Molecular Brain

Astrocyte calcium signaling and epilepsy

(2012) Giorgio Carmignoto et al.   GLIA

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo

(2012) H. A. Zariwala et al.   JOURNAL OF NEUROSCIENCE

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes

(2012) Cendra Agulhon et al.   Frontiers in Pharmacology

Astrocytic P2Y1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia

(2011) Kazuya Kuboyama et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bulk Loading of Calcium Indicator Dyes to Study Astrocyte Physiology: Key Limitations and Improvements Using Morphological Maps

(2011) A. M. B. Reeves et al.   JOURNAL OF NEUROSCIENCE

TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus

(2011) Mirko Santello et al.   NEURON

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

Astrocytic dysfunction: Insights on the role in neurodegeneration

(2009) Daniela Rossi et al.   BRAIN RESEARCH BULLETIN

Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes

(2009) Schuichi Koizumi   FEBS Journal

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Photothrombosis ischemia stimulates a sustained astrocytic Ca2+signalingin vivo

(2008) Shinghua Ding et al.   GLIA

Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons

(2008) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Loss of IP3 Receptor-Dependent Ca2+ Increases in Hippocampal Astrocytes Does Not Affect Baseline CA1 Pyramidal Neuron Synaptic Activity

(2008) J. Petravicz et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE