Review
Biochemistry & Molecular Biology
Stefan Rose-John
Summary: Interleukin-6 is an inflammatory cytokine whose level is elevated in inflammatory states, triggering cell-specific responses. The activation of gp130 in hepatocytes produces both liver-specific and systemic effects.
Article
Neurosciences
Zude Zhu, Jia Deng, Mengya Li, Ye Qin, Jingyi Li, Yiming Yang
Summary: This study investigated the contribution of brain structure and processing speed to age-related changes in semantic fluency. The results showed that the decline in semantic fluency with age was associated with reductions in gray matter volume in widespread fronto-temporal regions and a decline in white matter integrity in brain tracts connecting these regions. Critically, low processing speed fully mediated the negative effects of lower gray matter volume and white matter integrity on semantic fluency. These findings support the processing speed theory in relation to age-related decline in semantic fluency and provide insights for improving cognitive decline.
NEUROSCIENCE LETTERS
(2022)
Article
Geriatrics & Gerontology
Ting Zhang, Yunyun Zhang, Ziyan Lv, Jie Xiang
Summary: This study aimed to investigate the association and potential pathways between sarcopenia and motoric cognitive risk syndrome (MCR) in community elderly individuals. The results showed that sarcopenia was associated with MCR, and apathy symptoms partially mediated this relationship. Physical activity played a moderating role, as increasing physical activity could alleviate the indirect effect of sarcopenia on MCR.
Review
Rheumatology
Desh Nepal, David Gazeley
Summary: This narrative review examines the role of IL-6 in murine and human SLE, and its potential use as a targeted therapy in future studies. Currently, there are no registered clinical trials assessing IL-6 inhibition in SLE.
Article
Health Care Sciences & Services
Hyunju Choi, HaeJin Shin
Summary: The present study aimed to examine the roles of hopelessness and cognitive control in the relationship between entrapment and depression. Data were collected from 367 college students in South Korea. Results showed that hopelessness partially mediated the relationship between entrapment and depression. In addition, cognitive control moderated the relationship between entrapment and hopelessness, and the mediating effect of hopelessness was moderated by cognitive control. The findings of this study expand the understanding of the protective role of cognitive control in intensifying depression caused by increased sense of entrapment and hopelessness.
Article
Immunology
Guoqiang Zhang, Hayato Iwase, Qi Li, Takayuki Yamamoto, Abhijit Jagdale, Mohamed B. Ezzelarab, David Ayares, David K. C. Cooper, Hidetaka Hara, Gangcheng Wang
Summary: In pig-to-baboon transplantation models, systemic inflammation factors such as SAA and IL-6 may indicate the development of rejection or infection, and are associated with impaired kidney graft function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Irsa Fatima Makhdoom, Najma Iqbal Malik, Mohsin Atta, Nudra Malik, Madeeha Gohar Qureshi, Muhammad Shahid, Kun Tang
Summary: This study analyzed the mediating role of psychological capital between workaholism and burnout, and examined the moderating role of time pressure and cognitive demands in this mediated relationship. Results showed that workaholism is indirectly related to burnout through psychological capital, and this mediated relationship is stronger for university employees facing higher levels of challenging job demands.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychology, Multidisciplinary
Chenjuan Jiang
Summary: This quantitative study explored the relationship between foreign language reading self-efficacy and reading performance. The findings showed a positive correlation between reading self-efficacy and reading performance, and a negative correlation between reading self-efficacy and intrinsic cognitive load. Reading boredom was negatively related to reading self-efficacy and reading performance, but positively related to cognitive load. The study also found that cognitive load mediated the relationship between reading self-efficacy and performance, while reading boredom moderated the relationship between reading self-efficacy and cognitive load.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Wen-Qi Xu, Li-Hua Lin, Kai-Rong Ding, Yun-Fei Ke, Jia-Hao Huang, Cai-Lan Hou, Fu-Jun Jia, Shi-Bin Wang
Summary: The study revealed the direct and indirect effects of poor sleep quality on SCD symptoms, with anxiety and depressive symptoms playing a mediating role and a serial mediating role in the relationship. The moderated mediation model showed that anxiety symptoms moderated the mediation of depressive symptoms on the relationship between poor sleep quality and SCD symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Yu Ling, Yuji You, Shiyu You, Miao Yu, Yixun Wang, Shuxin Zheng, E. Scott Huebner, Mingtian Zhong
Summary: We proposed a moderated mediation model to investigate the relations between social support and Internet addiction in adolescents, and found that social support was significantly inversely related to Internet addiction. Negative coping behavior played a mediating role in the relation between them. Adolescents' use of cognitive reappraisal strategies moderated the mediating path between social support and negative coping.
CURRENT PSYCHOLOGY
(2023)
Editorial Material
Cell Biology
Brianna Cyr, Juan Pablo de Rivero Vaccari
Summary: The study investigates the effect of age on brain inflammation response, finding that older individuals exhibit more exacerbated inflammatory immune responses when faced with systemic infections.
Article
Endocrinology & Metabolism
Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Summary: The bidirectional interaction between adipocytes and adipose tissue immune cells is crucial for regulating adipose function, inflammation, and insulin responsiveness. Obesity reduces cAMP-driven IL-6 secretion from adipocytes, but restoring their catecholamine sensitivity can stimulate IL-6 secretion and activate macrophages to promote an anti-inflammatory gene expression pattern.
Article
Neurosciences
Mans Gyllenhammar, Anna Rennie, Daniel Ferreira Padilla, John Wallert, Anders Rydstrom, Lars-Olof Wahlund, Maria Eriksdotter, Eric Westman, Urban Ekman
Summary: Education level is associated with atrophy in the medial temporal lobe and memory, with education moderating the effect of atrophy on memory.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Summary: PGK1 plays a role in immunometabolism by influencing metabolic status. The inhibitor DC-PGKI can suppress the activity of PGK1 and alleviate symptoms of inflammatory bowel disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Geriatrics & Gerontology
Phoebe E. Bailey, Brooke Brady, Natalie C. Ebner, Ted Ruffman
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2020)
Review
Behavioral Sciences
Marilyn Horta, Kathryn Kaylor, David Feifel, Natalie C. Ebner
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Neurosciences
Anne C. Laurita, Elizabeth DuPre, Natalie C. Ebner, Gary R. Turner, R. Nathan Spreng
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2020)
Review
Psychology, Biological
Didem Pehlivanoglu, Elisha Myers, Natalie C. Ebner
BIOLOGICAL PSYCHOLOGY
(2020)
Article
Psychology, Clinical
Ben Lewis, Julianne L. Price, Christian C. Garcia, Natalie C. Ebner, Sara Jo Nixon
Summary: The study found that individuals with AUD showed differences in working memory performance when attending to and ignoring facial stimuli, with poorer performance observed when ignoring faces. Compared to the control group, the AUD group exhibited decreased performance when ignoring facial stimuli, conditioned on the inability to ignore irrelevant emotional face stimuli, while performance was equivalent between groups when faces were attended.
ADDICTIVE BEHAVIORS
(2021)
Article
Gerontology
Shenyang Huang, Leonard Faul, Gunes Sevinc, Laetitia Mwilambwe-Tshilobo, Roni Setton, Amber W. Lockrow, Natalie C. Ebner, Gary R. Turner, R. Nathan Spreng, Felipe De Brigard
Summary: Older adults tend to endorse deontological decisions, especially when the choice is intuitive, while there is no difference between younger and older adults in utilitarian decisions when intuitive. Enhanced brain connections in older adults are associated with their increased deontological-intuitive moral decision-making style.
PSYCHOLOGY AND AGING
(2021)
Article
Geriatrics & Gerontology
Tian Lin, Marilyn Horta, Kristen Heald, Amber Heemskerk, Bri Darboh, Adina Levi, R. Nathan Spreng, Gary R. Turner, Natalie C. Ebner
Summary: This study examines the impact of COVID-19-related physical distancing guidelines on loneliness among older adults in North America. The findings suggest that loneliness levels remained stable overall, but there were gender differences observed between the United States and Canada. The study emphasizes the need for targeted interventions to address acute loneliness among older populations.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Tian Lin, Elizabeth A. Harris, Amber Heemskerk, Jay J. Van Bavel, Natalie C. Ebner
Summary: This study explores the impact of age, gender, and national levels of human development on self-reported compliance with COVID-19 public health measures. Older age, female gender, and lower human development index were independently associated with greater self-reported compliance. The findings suggest the potential for tailored health campaigns and policies targeted towards specific demographics and countries in combating a global pandemic.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Behavioral Sciences
Jillian M. Rung, Quintin A. Kidder, Marilyn Horta, H. P. Nazarloo, C. Sue Carter, Meredith S. Berry, Natalie C. Ebner
Summary: This study evaluated the relationship between alcohol use and oxytocin (OT) activity and found significant associations between the two, supporting the involvement of the OT system in alcohol use.
BRAIN AND BEHAVIOR
(2022)
Article
Psychology, Applied
Didem Pehlivanoglu, Nichole R. Lighthall, Tian Lin, Kevin J. Chi, Rebecca Polk, Eliany Perez, Brian S. Cahill, Natalie C. Ebner
Summary: Increasing misinformation spread poses a threat to older adults, but there is limited research on older adults and fake news. This study found that fake news detection was comparable between young and older adults, and individual differences in analytic reasoning predicted fake news detection for both age groups. However, chronological age effects and their interaction with components such as analytical reasoning, affect, and news consumption frequency emerged within the older adult sample. These findings enhance our understanding of the psychological mechanisms involved in news veracity detection in aging.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-APPLIED
(2022)
Article
Biology
Rebecca Polk, Marilyn Horta, Tian Lin, Eric Porges, Marite Ojeda, Hans P. Nazarloo, C. Sue Carter, Natalie C. Ebner
Summary: This study investigated the associations between plasma oxytocin and arginine-vasopressin levels and dynamic emotion identification accuracy in older men. The results showed that higher plasma oxytocin levels were associated with lower accuracy, and this relationship was fully mediated by cognition. In contrast, plasma arginine-vasopressin levels did not show any association with dynamic emotion identification accuracy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Didem Pehlivanoglu, Tian Lin, Nichole R. Lighthall, Amber Heemskerk, Alexandria Harber, Robert C. Wilson, Gary R. Turner, R. Nathan Spreng, Natalie C. Ebner
Summary: This study investigates the influences of perceiver age, facial age, and facial emotion on facial trustworthiness perception. The results show that young faces are perceived as the most trustworthy, while older faces are seen as the least trustworthy, particularly by middle-aged and older perceivers. Facial emotions signaling threat moderate the age effects on facial trustworthiness perception.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Computer Science, Software Engineering
Yuriy Brun, Tian Lin, Jessie Elise Somerville, Elisha M. Myers, Natalie Ebner
Summary: Blindspots in APIs can lead to vulnerabilities and are common. Using APIs with blindspots reduces developers' ability to reason about them, especially in Python. Interestingly, Python developers are less likely to notice vulnerabilities in complex code, while Java developers are more careful with complex code but more careless with simple code. Long-term memory recall improves developers' ability to reason about APIs with blindspots, but other memory factors have no effect. Experience and expertise do not help in recognizing blindspots, and personality traits only affect the ability to reason about Java APIs with blindspots. Overall, tools are needed to help developers recognize blindspots in APIs as they write code.
ACM TRANSACTIONS ON SOFTWARE ENGINEERING AND METHODOLOGY
(2023)
Article
Neurosciences
Lindsay B. Conner, Marilyn Horta, Natalie C. Ebner, Nichole R. Lighthall
Summary: The study found that activation in the fronto-striatal reward circuit and posterior parietal cortex during value phases was comparable, but activation in select fronto-parietal and salience regions was significantly greater during value retrieval than encoding. There was no interaction between neural correlates of valuation and episodic memory.
BRAIN AND COGNITION
(2021)
