Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand–Induced Apoptosis and Lung Injury in Mice

Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models

(2016) Katrin Schindler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

(2015) Liang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of Hypoxia-Inducible Factor-1α in Type 2 Alveolar Epithelial Cell Is a Major Driver of Acute Inflammation Following Lung Contusion*

(2014) Madathilparambil V. Suresh et al.   CRITICAL CARE MEDICINE

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

(2014) C. M. Taniguchi et al.   Science Translational Medicine

The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs

(2013) Raquel Herrero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway

(2013) Andreas A. Kroon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways

(2013) C. C. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

(2012) J. Kiss et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Inducible Factor Activation Protects the Kidney from Gentamicin-Induced Acute Injury

(2012) Jeong-myung Ahn et al.   PLoS One

HIF and the Lung

(2011) Larissa A. Shimoda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fas Activation in Alveolar Epithelial Cells Induces KC (CXCL1) Release by a MyD88-Dependent Mechanism

(2011) Alex W. Farnand et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals

(2011) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region

(2011) Raquel Herrero et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpesvirus entry mediator regulates hypoxia-inducible factor–1α and erythropoiesis in mice

(2011) Yukimi Sakoda et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

(2011) Emily Hams et al.   SHOCK

Hydroxylase Inhibition Abrogates TNF- -Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1-Dependent Repression of FADD

(2010) P. Hindryckx et al.   JOURNAL OF IMMUNOLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

FADD: a regulator of life and death

(2010) Léa Tourneur et al.   TRENDS IN IMMUNOLOGY

Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice

(2008) R. A. Bem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY