Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

Innate and ozone-induced airway hyperresponsiveness in obese mice: role of TNF-α

(2015) Alison Suzanne Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Maternal high-fat diet is associated with impaired fetal lung development

(2015) Reina S. Mayor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation

(2015) Farida Ahangari et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-β–Mediated Collagen Production in a Murine Asthma Model

(2015) Omar A. Jaffer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Association between Western diet pattern and adult asthma: a focused review

(2015) Emily P. Brigham et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Body mass index correlates with pollutant-induced interleukin-1β in sputum and blood

(2015) Krista Todoric et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Airway epithelial NF-κB activation promotes the ability to overcome inhalational antigen tolerance

(2015) J. L. Ather et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Obesity shifts house dust mite-induced airway cellular infiltration from eosinophils to macrophages: effects of glucocorticoid treatment

(2015) J. Diaz et al.   IMMUNOLOGIC RESEARCH

Potential role of the airway wall in the asthma of obesity

(2015) Jason H. T. Bates et al.   JOURNAL OF APPLIED PHYSIOLOGY

Immunometabolism: Cellular Metabolism Turns Immune Regulator

(2015) Róisín M. Loftus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes

(2015) C. Lawrence Kien et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and Asthma-Like Changes in Lungs

(2015) Vijay Pal Singh et al.   PLoS One

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Increased Airway Reactivity and Hyperinsulinemia in Obese Mice Are Linked by ERK Signaling in Brain Stem Cholinergic Neurons

(2015) Luiz O.S. Leiria et al.   Cell Reports

Obesity Increases Airway Hyperresponsiveness via the TNF-α Pathway and Treating Obesity Induces Recovery

(2015) Joo Young Kim et al.   PLoS One

Pivotal role of IL-6 in the hyperinflammatory responses to subacute ozone in adiponectin-deficient mice

(2014) David I. Kasahara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice

(2014) Paul H. Dahm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Eosinophilic Inflammation in Subjects with Mild-to-Moderate Asthma with and without Obesity: Disparity between Sputum and Biopsies

(2014) Erica van der Wiel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Obese Individuals with Asthma Preferentially Have a High IL-5/IL-17A/IL-25 Sputum Inflammatory Pattern

(2014) Gudrun S. Marijsse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Nonallergic Asthma of Obesity. A Matter of Distal Lung Compliance

(2014) Ali Al-Alwan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Influence of distinct asthma phenotypes on lung function following weight loss in the obese

(2014) David G. Chapman et al.   RESPIROLOGY

Aligning mouse models of asthma to human endotypes of disease

(2014) Rebecca A. Martin et al.   RESPIROLOGY

Induction of IL-17A Precedes Development of Airway Hyperresponsiveness during Diet-Induced Obesity and Correlates with Complement Factor D

(2014) Joel A. Mathews et al.   Frontiers in Immunology

Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma

(2013) Dhananjay Desai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-1 Receptor and Caspase-1 Are Required for the Th17 Response in Nitrogen Dioxide–Promoted Allergic Airway Disease

(2013) Rebecca A. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of Leptin Regulation of Parasympathetic Signaling as a Cause of Extreme Body Weight-Associated Asthma

(2013) Emilio Arteaga-Solis et al.   Cell Metabolism

High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice

(2013) Xiao Na Ge et al.   EXPERIMENTAL LUNG RESEARCH

Being overweight increases susceptibility to indoor pollutants among urban children with asthma

(2013) Kim D. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Predictors of response to tiotropium versus salmeterol in asthmatic adults

(2013) Stephen P. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma

(2013) Michael Schatz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association study of mitochondrial genetic polymorphisms in asthmatic children

(2013) Antònia Flaquer et al.   MITOCHONDRION

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Role of the Adiponectin Binding Protein, T-Cadherin (cdh13), in Pulmonary Responses to Subacute Ozone

(2013) David I. Kasahara et al.   PLoS One

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

(2013) E.P. Taddeo et al.   Molecular Metabolism

An Association betweenl-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

(2012) Fernando Holguin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the Seven Northeastern Cities study

(2012) G H Dong et al.   INTERNATIONAL JOURNAL OF OBESITY

Role of TNFR1 in the innate airway hyperresponsiveness of obese mice

(2012) Ming Zhu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary Inflammation Induced by Subacute Ozone Is Augmented in Adiponectin-Deficient Mice: Role of IL-17A

(2012) D. I. Kasahara et al.   JOURNAL OF IMMUNOLOGY

Allergen-Induced Bone Marrow Eosinophilopoiesis and Airways Eosinophilic Inflammation in Leptin-Deficient ob/ob Mice

(2012) Leticia Lintomen et al.   Obesity

Cluster Analysis of Obesity and Asthma Phenotypes

(2012) E. Rand Sutherland et al.   PLoS One

Role of the Adiponectin Binding Protein, T-Cadherin (Cdh13), in Allergic Airways Responses in Mice

(2012) Alison S. Williams et al.   PLoS One

Obesity and airway responsiveness: Role of TNFR2

(2012) Alison S. Williams et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Epithelial, dendritic, and CD4+ T cell regulation of and by reactive oxygen and nitrogen species in allergic sensitization

(2011) Karina Ckless et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nitric oxide metabolism in asthma pathophysiology

(2011) Sudakshina Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation

(2011) Anne E. Dixon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Obesity and asthma: An association modified by age of asthma onset

(2011) Fernando Holguin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma

(2011) Lisa G. Wood et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitochondrial genetic background plays a role in increasing risk to asthma

(2011) Emily Zifa et al.   MOLECULAR BIOLOGY REPORTS

Airway Epithelial NF-κB Activation Promotes Allergic Sensitization to an Innocuous Inhaled Antigen

(2010) Jennifer L. Ather et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Obesity enhances eosinophilic inflammation in a murine model of allergic asthma

(2010) MC Calixto et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia

(2009) A. de Vries et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Obesity, asthma, and oxidative stress

(2009) Fernando Holguin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial Dysfunction Increases Allergic Airway Inflammation

(2009) L. Aguilera-Aguirre et al.   JOURNAL OF IMMUNOLOGY

Airway inflammation in obese and nonobese patients with difficult-to-treat asthma

(2008) I. H. van Veen et al.   ALLERGY

Nuclear Factor-κB Activation in Airway Epithelium Induces Inflammation and Hyperresponsiveness

(2008) Cristen Pantano et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Obesity and Asthma

(2008) Andréa Lessard et al.   CHEST

The relationship between obesity and asthma severity and control in adults

(2008) David M. Mosen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation

(2008) Richard A. Johnston et al.   JOURNAL OF APPLIED PHYSIOLOGY

No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice

(2008) Stephanie A. Shore et al.   JOURNAL OF APPLIED PHYSIOLOGY

BMI and Health Status Among Adults With Asthma

(2008) Michael Vortmann et al.   Obesity

Body mass index and asthma severity in the National Asthma Survey

(2007) B Taylor et al.   THORAX