Article
Endocrinology & Metabolism
Shiro Fukuda, Shunbun Kita, Kazuya Miyashita, Masahito Iioka, Jun Murai, Tadashi Nakamura, Hitoshi Nishizawa, Yuya Fujishima, Jun Morinaga, Yuichi Oike, Norikazu Maeda, Iichiro Shimomura
Summary: Three novel forms of soluble T-cad were identified in human serum. The importance of these forms as disease markers and/or biomarkers of adiponectin function, as well as the potential bioactivity of the respective molecules, require further investigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Vladimir S. Popov, Ilya B. Brodsky, Maria N. Balatskaya, Alexander V. Balatskiy, Ilia D. Ozhimalov, Maria A. Kulebyakina, Ekaterina V. Semina, Mikhail S. Arbatskiy, Viktoria S. Isakova, Polina S. Klimovich, Veronika Y. Sysoeva, Natalia I. Kalinina, Vsevolod A. Tkachuk, Kseniya A. Rubina
Summary: This study investigates the role of T-cadherin in regulating blood pressure and stamina by generating mice lacking exon 3 in the Cdh13 gene. The results show that Cdh13(?Exon3) mice have slightly higher blood pressure compared to wild-type mice, and their systolic blood pressure increases significantly after intensive physical training. Additionally, Cdh13(?Exon3) mice have significantly higher plasma adiponectin levels, and intensive physical training increases AMPK phosphorylation in their skeletal muscles and myocardium. These findings highlight the critical importance of T-cadherin in blood pressure regulation and stamina in mice and may provide insight into the pathogenesis of hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yuri Tsugawa-Shimizu, Yuya Fujishima, Shunbun Kita, Satoshi Minami, Taka-Aki Sakaue, Yuto Nakamura, Tomonori Okita, Yusuke Kawachi, Shiro Fukada, Tomoko Namba-Hamano, Yoshitsugu Takabatake, Yoshitaka Isaka, Hitoshi Nishizawa, Barbara Ranscht, Norikazu Maeda, Iichiro Shimomura
Summary: The study showed that APN protects the kidney in an acute renal injury model by binding to T-cadherin. T-cadherin-associated adiponectin protein exists on peritubular capillary pericytes, and deficiency of both leads to more severe renal tubular damage and increased vascular permeability. These findings suggest that APN and T-cadherin play an important role in maintaining the capillary network and ameliorating renal tubular injury.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Oncology
Yuan Shao, Wenxia Li, Lin Zhang, Bo Xue, Yongquan Chen, Zikuan Zhang, Dongwen Wang, Bo Wu
Summary: CDH13 is upregulated in clear cell renal cell carcinoma (ccRCC) and strongly correlated with better survival, lower cancer stages, and lower tumor grades of ccRCC patients. It may play a crucial role in regulating the tumor microenvironment of ccRCC. The altered epigenetic status of CDH13 and its prognosis are associated with DNA methylation and m6A modification.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Immunology
Benjamin J. Ulrich, Rakshin Kharwadkar, Michelle Chu, Abigail Pajulas, Charanya Muralidharan, Byunghee Koh, Yongyao Fu, Hongyu Gao, Tristan A. Hayes, Hong-Ming Zhou, Nick P. Goplen, Andrew S. Nelson, Yunlong Liu, Amelia K. Linnemann, Matthew J. Turner, Paula Licona-Limon, Richard A. Flavell, Jie Sun, Mark H. Kaplan
Summary: In this study, a specific subpopulation of CD4(+) T cells that secrete IL-9 was identified in a mouse model of chronic allergen exposure. These IL-9-secreting cells have a resident memory T cell phenotype and play a crucial role in the allergic recall response, as blocking or deleting IL-9 significantly reduced airway inflammation and hyperreactivity.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexander Balatskiy, Marina Teterina, Alexandra Pisaryuk, Irina Balabanenko, Alexey Kadrev, Anastasia Tishuk, Maria Balatskaya, Larisa Samokhodskaya, Sergey Boytsov, Natalia Kalinina, Vsevolod Tkachuk
Summary: The study found an inverse correlation between carotid artery IMT and HMW levels in male subjects. The G allele of rs12444338 SNP in the T-cadherin gene was associated with lower levels of circulating T-cadherin and thinner IMT, suggesting a potential atheroprotective genotype.
Article
Biochemistry & Molecular Biology
Simon G. Royce, Paul V. Licciardi, Raymond C. Beh, Jane E. Bourke, Chantal Donovan, Andrew Hung, Ishant Khurana, Julia J. Liang, Scott Maxwell, Nadia Mazarakis, Eleni Pitsillou, Ya Yun Siow, Kenneth J. Snibson, Mark J. Tobin, Katherine Ververis, Jitraporn Vongsvivut, Mark Ziemann, Chrishan S. Samuel, Mimi L. K. Tang, Assam El-Osta, Tom C. Karagiannis
Summary: LSF can prevent or reverse symptoms of asthma induced by OVA by its antioxidant and anti-inflammatory effects, and may exert its effects through epigenetic mechanisms that regulate gene expression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Justine Smout, Clara Valentin, Sandrine Delbauve, Jeanne Pauwels, Arnaud Kohler, Veronique Flamand
Summary: Oral supplementation of Lactobacillus rhamnosus during pregnancy/breastfeeding in mice reduces the development of allergic airways disease in their offspring, by increasing the number and maturation of splenic neonatal cDC1 cells, and promoting Th1 differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xuerong Gao, Chaoming Mao, Tingting Zheng, Xiaowei Xu, Xinkai Luo, Shan Zhang, Jiameng Liu, Xuefeng Wang, Xiaojun Chen, Liyang Dong
Summary: In this study, the efficacy of SJMHE1, a small molecular peptide derived from Schistosoma japonicum, in the treatment of ovalbumin-induced allergic rhinitis (AR) in mice was investigated. SJMHE1 treatment improved clinical symptoms, suppressed inflammation, and modulated the production of cytokines in various tissues. The results suggest that SJMHE1 may alleviate AR by upregulating regulatory B cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Imke Lingel, Adrienne N. Wilburn, Julie Hargis, Jaclyn W. McAlees, Yves Laumonnier, Claire A. Chougnet, Hitesh Deshmukh, Peter Koenig, Ian P. Lewkowich, Inken Schmudde
Summary: Changes in microbiome contribute to severity of allergic asthma. Prenatal antibiotic-induced dysbiosis leads to long-term immunological effects in offspring and increases asthma severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Susanne Krammer, Zuqin Yang, Theodor Zimmermann, Paraskevi Xepapadaki, Carol I. Geppert, Nikolaos G. Papadopoulos, Susetta Finotto
Summary: IL-3 plays an important regulatory role in pediatric asthma, and its association with steroid therapy needs further investigation; rIL-3 treatment can ameliorate airway eosinophilia and mucus production, providing a new strategy for treating allergic asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dae Woon Choi, Sun Young Jung, Gun-Dong Kim, So-Young Lee, Hee Soon Shin
Summary: MQL exhibits anti-allergic properties by suppressing Th2 cell-mediated allergic responses through multiple pathways, and may serve as a potential therapeutic agent for allergic diseases.
Article
Immunology
Junjie Ma, Egon Urgard, Solveig Runge, Cajsa H. Classon, Laura Mathae, Julian M. Stark, Liqin Cheng, Javiera A. Alvarez, Silvia Von Zedtwitz, Austeja Baleviciute, Sergio Martinez Hoyer, Muzhen Li, Anne Marleen Gernand, Lisa Osbelt, Agata Anna Bielecka, Till R. Lesker, Huey-Jy Huang, Susanne Vrtala, Louis Boon, Rudi Beyaert, Mikael Adner, Itziar Martinez Gonzalez, Till Strowig, Juan Du, Susanne Nylen, Stephan P. Rosshart, Jonathan M. Coquet
Summary: Allergic disorders are influenced by both hereditary and environmental factors. The hygiene hypothesis suggests that early-life exposure to microbes can affect the development of allergic diseases. By comparing wildling mice with conventional SPF mice, researchers were able to separate the impact of lifelong microbial exposures from genetic factors on the allergic immune response. The study found that wildlings developed stronger immune responses to allergens compared to SPF mice.
SCIENCE IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tomonori Okita, Shunbun Kita, Shiro Fukuda, Keita Fukuoka, Emi Kawada-Horitani, Masahito Iioka, Yuto Nakamura, Yuya Fujishima, Hitoshi Nishizawa, Dan Kawamori, Taka-aki Matsuoka, Maeda Norikazu, Iichiro Shimomura
Summary: This study identified a blood factor called T-cadherin, which promotes pancreatic beta-cell proliferation through the Notch signaling pathway under diabetic conditions. This finding provides new insights into the pathogenesis of diabetes.
Article
Multidisciplinary Sciences
Harpreet Kaur, Dana C. Crawford, Jingjing Liang, Penelope Benchek, Xiaofeng Zhu, Asha R. Kallianpur, William S. Bush
Summary: This study found that European-descent and African American populations share some genetic loci associated with blood pressure traits and hypertension. However, there are differences in OR and beta-coefficient estimates, and some associations are age-dependent. Further genetic studies of hypertension in African Americans are needed to identify new loci associated with hypertension and blood pressure traits in this population.
Article
Physiology
Liliana Moreno-Vinasco, Norah G. Verbout, Allison D. Fryer, David B. Jacoby
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2009)
Article
Physiology
David I. Kasahara, Hye Y. Kim, Joel A. Mathews, Norah G. Verbout, Alison S. Williams, Allison P. Wurmbrand, Fernanda M. C. Ninin, Felippe L. Neto, Leandro A. P. Benedito, Christopher Hug, Dale T. Umetsu, Stephanie A. Shore
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Ming Zhu, Christopher Hug, David I. Kasahara, Richard A. Johnston, Alison S. Williams, Norah G. Verbout, Huiqing Si, Jordan Jastrab, Amit Srivastava, Erin S. Williams, Barbara Ranscht, Stephanie A. Shore
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2010)
Article
Hematology
Erik I. Tucker, Norah G. Verbout, Philberta Y. Leung, Sawan Hurst, Owen J. T. McCarty, David Gailani, Andras Gruber
Article
Respiratory System
M. Zhu, P-Y. Liu, D. I. Kasahara, A. S. Williams, N. G. Verbout, A. J. Halayko, A. Fedulov, T. Shoji, E. S. Williams, K. Noma, S. A. Shore, J. K. Liao
EUROPEAN RESPIRATORY JOURNAL
(2011)
Article
Physiology
Stephanie A. Shore, Jason E. Lang, David I. Kasahara, Frank L. Lu, Norah G. Verbout, Huiqing Si, Erin S. Williams, Raya D. Terry, Anna Lee, Richard A. Johnston
JOURNAL OF APPLIED PHYSIOLOGY
(2009)
Article
Immunology
David I. Kasahara, Hye Y. Kim, Alison S. Williams, Norah G. Verbout, Jennifer Tran, Huiqing Si, Allison P. Wurmbrand, Jordan Jastrab, Christopher Hug, Dale T. Umetsu, Stephanie A. Shore
JOURNAL OF IMMUNOLOGY
(2012)
Article
Cell Biology
Asako Itakura, Norah G. Verbout, Kevin G. Phillips, Robert H. Insall, David Gailani, Erik I. Tucker, Andras Gruber, Owen J. T. McCarty
JOURNAL OF LEUKOCYTE BIOLOGY
(2011)
Article
Hematology
D. C. Wood, L. A. Pelc, N. Pozzi, M. Wallisch, N. G. Verbout, E. I. Tucker, A. Gruber, E. Di Cera
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2015)
Article
Endocrinology & Metabolism
Norah G. Verbout, Xiaolin Yu, Laura D. Healy, Kevin G. Phillips, Erik I. Tucker, Andras Gruber, Owen J. T. McCarty, Halina Offner
METABOLIC BRAIN DISEASE
(2015)
Article
Clinical Neurology
Philberta Y. Leung, Sawan Hurst, Michelle A. Berny-Lang, Norah G. Verbout, David Gailani, Erik I. Tucker, Ruikang K. Wang, Owen J. T. McCarty, Andras Gruber
TRANSLATIONAL STROKE RESEARCH
(2012)
Article
Hematology
Christina U. Lorentz, Norah G. Verbout, Michael Wallisch, Matthew W. Hagen, Joseph J. Shatzel, Sven R. Olson, Cristina Puy, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Andras Gruber, Erik I. Tucker
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Hematology
Christina U. Lorentz, Norah G. Verbout, Zhiping Cao, Lijuan Liu, Monica T. Hinds, Owen J. T. McCarty, Ivan Ivanov, Erik I. Tucker, David Gailani, Andras Gruber
Meeting Abstract
Critical Care Medicine
D. I. Kasahara, H. Y. Kim, A. S. Williams, N. Verbout, C. Hug, D. Umetsu, S. Shore
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2011)